Emulation of electrophysiological signals derived by stimulation of a body

Patent metadata

Field	Value
Publication number	US-12005260-B2
Application number	US-202017429388-A
Country	US
Kind code	B2
Filing date	Feb 13, 2020
Priority date	Feb 13, 2019
Publication date	Jun 11, 2024
Grant date	Jun 11, 2024

Abstract

An emulation apparatus emulates an electrophysiological signal derived from a target area of a human or animal nervous system under the influence of a stimulation signal applied to the human or animal body. A prior signal generator generates a prior signal representing an electrophysiological signal in the absence of stimulation. A test signal representing a stimulation signal is received and used by a modelling unit to derive a modulation signal representing the degree of modulation of the electrophysiological signal, in accordance with a model of the temporal evolution of the modulation of the electrophysiological signal caused by the stimulation signal. A modulation unit modulates the prior signal in accordance with the modulation signal to output an emulation signal representing an electrophysiological signal derived under the influence of the stimulation signal. The emulation apparatus has wide use in neuroscience research, bioengineering and clinical applications.

First claim

The invention claimed is:

1. An emulation apparatus arranged to emulate an electrophysiological signal derived from a target area of the nervous system of a human or animal body under the influence of a stimulation signal applied to the human or animal body, the emulation apparatus comprising:
a prior signal generator arranged to generate a prior signal representing the electrophysiological signal derived from the target area of the nervous system of the human or animal body in the absence of the stimulation signal;
a test signal input arranged to receive a test signal representing the stimulation signal applied to the human or animal body;
a modelling unit arranged to derive a modulation signal, which modulation signal represents a degree of modulation of the electrophysiological signal by the stimulation signal, from the test signal in accordance with a model implemented within the modelling unit of a temporal evolution of the modulation of the electrophysiological signal caused by the stimulation signal; and
a modulation unit arranged to modulate the prior signal in accordance with the modulation signal to output an emulation signal representing an electrophysiological signal derived under the influence of the stimulation signal.

2. An emulation apparatus according to claim 1 , wherein the model represents an algebraic change in the modulation with at least one parameter of the stimulation signal.

3. An emulation apparatus according to claim 1 , wherein the model includes two cascaded differential stages with time constants of different orders of magnitude.

4. An emulation apparatus according to claim 3 , wherein one of the time constants correspond to a low pass response of neural membranes of neurons to the stimulation signal.

5. An emulation apparatus according to claim 3 , wherein one of the time constants represents a dynamic response of a gross average of the electrophysiological signal derived from the target area of the nervous system to the stimulation signal.

6. An emulation apparatus according to claim 1 , wherein the model further represents a saturation of the modulation at a magnitude that is dependent on at least one parameter of the stimulation signal.

7. An emulation apparatus according to claim 6 , wherein the model further represents the saturation of the modulation at magnitudes that are dependent on plural parameters of the stimulation signal.

8. An emulation apparatus according to claim 1 , wherein the model represents a gain of the modulation with respect to plural parameters of the stimulation signal.

9. An emulation apparatus according to claim 1 , further comprising an external disturbance signal generator arranged to generate an external disturbance signal representing external disturbances to the electrophysiological signal, the modulation unit being arranged to add the external disturbance signal to the emulation signal.

10. An emulation apparatus according to claim 9 , wherein the external disturbances include one or more of:
artefacts of the stimulation signal on the signal measured from the human or animal body;
DC-drift bias;
electrocardiogram artefacts; and
electrical noise.

11. An emulation apparatus according to claim 1 , wherein the electrophysiological signal comprises a signal representing a frequency domain parameter of a signal measured from the human or animal body.

12. An emulation apparatus according to claim 1 , wherein the prior signal is a synthetic signal, or the prior signal is, or is derived from, a signal measured from an actual human or animal body.

13. An emulation apparatus according to claim 1 , wherein the test signal comprises a temporal signal representing the stimulation signal or comprises parameters representing a waveform of the stimulation signal.

14. An emulation apparatus according to claim 1 implemented by electronic components.

15. A method of emulating an electrophysiological signal derived from a target area of the nervous system of a human or animal body under the influence of a stimulation signal applied to the human or animal body, the method comprising:
generating a prior signal representing the electrophysiological signal derived from the target area of the nervous system of the human or animal body in the absence of the stimulation signal;
receiving a test signal representing the stimulation signal applied to the human or animal body;
deriving a modulation signal, which modulation signal represents a degree of modulation of the electrophysiological signal by the stimulation signal, from the test signal in accordance with a model of a temporal evolution of the modulation of the electrophysiological signal caused by the stimulation signal; and
modulating the prior signal in accordance with the modulation signal to output an emulation signal representing an electrophysiological signal derived under the influence of the stimulation signal.

16. A method according to claim 15 , wherein the model represents an exponential decrease in the modulation with at least one parameter of the stimulation signal.

17. A method according to claim 15 , wherein the model includes two cascaded first-order continuous-time stages with time constants of different orders of magnitude.

18. A method according to claim 17 , wherein one of the time constants represents a low pass response of neural membranes of neurons to the stimulation signal.

19. A method according to claim 17 , wherein one of the time constants represents a dynamic response of an envelope of the electrophysiological signal derived from the target area of the nervous system to the stimulation signal.

20. A method according to claim 15 , wherein the model further represents a saturation of the modulation at a magnitude that is dependent on at least one parameter of the stimulation signal.

21. A method according to claim 20 , wherein the model further represents a saturation of the modulation at magnitudes that are dependent on plural parameters of the stimulation signal.

22. A method according to claim 15 , wherein the model represents a gain of the modulation that is dependent on plural parameters of the stimulation signal.

23. A method according to claim 15 , further comprising generating an external disturbance signal representing external disturbances to the electrophysiological signal, and adding the external disturbance signal to the emulation signal.

24. A method according to claim 23 , wherein the external disturbances include one or more of:
artefacts of the stimulation signal on the signal measured from the human or animal body;
DC-drift bias;
electrocardiogram artefacts; and
electrical noise.

25. A method according to claim 15 , wherein the electrophysiological signal comprises a signal representing a frequency domain parameter of a signal measured from the human or animal body.

26. A method according to claim 15 , wherein the prior signal is a synthetic signal, or the prior signal is, or is derived from, a signal measured from an actual human or animal body.

27. A method according to wherein the test signal comprises a temporal signal representing the stimulation signal or comprises parameters representing a waveform of the stimulation signal.

28. A non-transitory computer program capable of execution by a computer apparatus and configured, on execution, to cause the computer apparatus to perform a method according to

Assignees

• Univ Oxford Innovation Ltd

Inventors

• Debarros Jean
• Brown Peter
• Tan Huiling
• Denison Timothy

Classifications

• A61N1/37241 Primary

  providing test stimulations · CPC title