Implantable medical devices

Patent metadata

Field	Value
Publication number	US-12005160-B2
Application number	US-202016996245-A
Country	US
Kind code	B2
Filing date	Aug 18, 2020
Priority date	Jul 24, 2009
Publication date	Jun 11, 2024
Grant date	Jun 11, 2024

Abstract

Implantable medical devices are provided. In one embodiment, a device includes a body having an external surface defining an outer profile of the device. The body includes a porous matrix including a series of interconnected macropores defined by a plurality of interconnected struts each including a hollow interior. A filler material substantially fills at least a portion of the series of interconnected macropores. The external surface of the body includes a plurality of openings communicating with the hollow interior of at least a portion of the plurality of interconnected struts. In a further aspect of this embodiment, the external surface includes exposed areas of the filler material and porous matrix in addition to the exposed openings. In another aspect, the porous matrix is formed from a bioresorbable ceramic and the filler material is a biologically stable polymeric material. Still, other aspects related to this and other embodiments are also disclosed.

First claim

What is claimed is:

1. A method for producing a medical implant, the method comprising:
providing a foam with interconnected pores;
impregnating the foam with a slurry of ceramic material to provide a coated foam structure wherein struts of the coated foam structure are coated with the slurry and voids of the coated foam structure are substantially filled with the slurry;
heating and sintering the coated foam structure to provide a ceramic matrix having a plurality of interconnected macropores defined by a plurality of interconnected struts;
sintering the ceramic matrix; and
infusing a filler material into and throughout the macropores,
wherein the interconnected struts each comprise a hollow portion, the hollow portions remaining substantially free of the filler material after the filler material is infused into and throughout the macropores.

2. The method of claim 1 , wherein the step of impregnating the foam structure with the slurry is repeated until the slurry forms a coating having a thickness between about 10 microns to about 100 microns.

3. The method of claim 1 , further comprising drying the coated foam structure, wherein the steps of impregnating the foam structure with the slurry and drying the coated foam structure are repeated until the coated foam structure has a compressive strength of about 10 MPa.

4. The method of claim 1 , wherein the step of impregnating the foam structure with the slurry comprises applying several coats of a slurry having up to 30% solids by volume and applying several coats of a slurry having below 20% solids by volume.

5. The method of claim 1 , wherein the step of heating and sintering the coated foam structure comprises heating the coated foam structure at temperatures of about 25° C. up to about 500° C. and sintering the coated foam structure at temperatures of about 900° C. to about 1,500° C.

6. The method of claim 1 , wherein the step of heating and sintering the coated foam structure is done by heating and sintering the coated foam structure in succession by ramping up temperature to a sintering temperature from a heating temperature.

7. The method of claim 6 , wherein the heating temperature is about 25° C. up to about 500° C. and the sintering temperature is about 900° C. to about 1,500° C.

8. The method of claim 1 , wherein the step of sintering the ceramic matrix comprises sintering the ceramic matrix at temperatures between about 1200° C. and about 1500° C.

9. The method of claim 1 , wherein the filler material comprises polyetheretherketone.

10. The method of claim 1 , wherein:
exposed areas of the ceramic matrix are free of the filler material after the filler material is infused into and throughout the macropores; and
the method further comprises processing the ceramic matrix into an implant body by machining, cutting, laser shaping, chemically degrading, etching, grinding, or peening the ceramic matrix such that areas of the implant body become exposed, at least some of the areas comprising the filler material.

11. The method of claim 1 , wherein the method further comprises processing the ceramic matrix into an implant body, the implant body having an external surface and a plurality of openings extending through the external surface, the openings communicating with the hollow portion of at least a portion of the plurality of interconnected struts.

12. The method of claim 1 , wherein the hollow portions remain entirely free of the filler material after the filler material is infused into and throughout the macropores.

13. A method for producing a medical implant, the method comprising:
providing a foam with interconnected pores;
impregnating the foam with a slurry of ceramic material to provide a coated foam structure wherein struts of the coated foam structure are coated with the slurry and voids of the coated foam structure are substantially filled with the slurry, the ceramic material having a particle size of up to 50 microns;
heating and sintering the coated foam structure to provide a ceramic matrix having a plurality of interconnected macropores defined by a plurality of interconnected struts;
sintering the ceramic matrix; and
infusing a filler material into and throughout the macropores,
wherein the interconnected struts each comprise a hollow portion, the hollow portions remaining substantially free of the filler material after the filler material is infused into and throughout the macropores.

14. The method of claim 13 , wherein the method further comprises processing the ceramic matrix into an implant body, the implant body having an external surface and a plurality of openings extending through the external surface, the openings communicating with the hollow portion of at least a portion of the plurality of interconnected struts.

15. The method of claim 13 , wherein the step of impregnating the foam structure with the slurry is repeated until the slurry forms a coating having a thickness between about 10 microns to about 100 microns.

16. The method of claim 13 , further comprising drying the coated foam structure, wherein the steps of impregnating the foam structure with the slurry and drying the coated foam structure are repeated until the coated foam structure has a compressive strength of about 10 MPa.

17. The method of claim 13 , wherein the step of impregnating the foam structure with the slurry comprises applying several coats of a slurry having up to 30% solids by volume and applying several coats of a slurry having below 20% solids by volume.

18. The method of claim 13 , wherein the step of heating and sintering the coated foam structure comprises heating the coated foam structure at temperatures of about 25° C. up to about 500° C. and sintering the coated foam structure at temperatures of about 900° C. to about 1,500° C.

19. The method of claim 13 , wherein the step of heating and sintering the coated foam structure is done by heating and sintering the coated foam structure in succession by ramping up temperature to a sintering temperature from a heating temperature.

20. A method for producing a medical implant, the method comprising:
providing a foam with interconnected pores;
preparing a slurry by combining ceramic material with a fluid medium and a dispersing agent, the ceramic material having a particle size of up to 50 microns, the dispersing agent being selected from a group consisting of sodium polyacrylate, ammonium polyacrylate, sodium citrate, sodium tartrate, sodium carbonate, sodium silicate and tetrasodium pyrophosphate, the dispersing agent comprising between about 1% and 3.5% by volume of the slurry;
impregnating the foam with the slurry to provide a coated foam structure wherein struts of the coated foam structure are coated with the slurry and voids of the coated foam structure are substantially filled with the slurry;
drying the coated foam structure, wherein the step of impregnating the foam structure with the slurry and drying the coated foam structure are repeated until the slurry forms a coating having a thickness between about 10 microns to about 100 microns and the coated foam structure has a compressive strength of about 10 MPa;
heating and sintering the coated foam structure to provide a ceramic matrix having a plurality of interconnected macropores defined by a plurality of interconnected struts, wherein the step of heating and sintering the coated foam structure is done by heating and sintering the coated foam structure in succession by ramping up temperature to a sintering temperature from a heating te

Assignees

• Warsaw Orthopedic Inc

Inventors

• Melkent Anthony J
• Thoren Brian R
• Smith Timothy J N
• Grant Ian D
• Dunkley Ian R

Classifications

• C04B2235/606

  Drying · CPC title

• C04B41/81

  Coating or impregnation · CPC title

• C04B41/4586

  Non-chemical aspects relating to the substrate being coated or impregnated · CPC title

• C04B38/0051

  characterised by the pore size, pore shape or kind of porosity · CPC title

• B29L2031/7532

  Artificial members, protheses · CPC title