High liquidus viscosity bioactive glass

Patent metadata

Field	Value
Publication number	US-11999653-B2
Application number	US-202217832208-A
Country	US
Kind code	B2
Filing date	Jun 3, 2022
Priority date	Nov 28, 2017
Publication date	Jun 4, 2024
Grant date	Jun 4, 2024

Abstract

Methods of making a bioactive glass fiber include forming a melt of a glass composition including: 50 to 70% SiO2; 0.1 to 10% Al2O3, 5 to 30% Na2O, 0.1 to 15% K2O, 0.1 to 15% MgO, 0.1 to 20% CaO, and 5 to 10% P2O5, based on a 100 wt % of the glass composition. The melt has a viscosity of from 200 Poise to 2,000 Poise. Methods include drawing the melt into a drawn glass fiber. Bioactive glass compositions include: 60 to 70% SiO2; 15 to 30% Na2O, 5 to 15% K2O, 1 to 10% CaO, and 5 to 10% P2O5, based on a 100 wt % of the glass composition.

First claim

What is claimed is:

1. A method of making a bioactive glass fiber comprising:
forming a melt of a glass composition comprising:
50 to 70% SiO 2 ,
5 to 30% Na 2 O,
0.1 to 15% K 2 O,
0.1 to 20% CaO, and
5 to 10% P 2 O 5 , based on a 100 wt % of the glass composition, wherein the melt has a viscosity of from 200 Poise to 2,000 Poise; and
drawing the melt into a drawn glass fiber;
wherein the glass composition is free of Al 2 O 3 , MgO, or both.

2. The method of claim 1 , wherein the drawn glass fiber has a diameter of from 1 micrometer to 100 micrometers.

3. The method of claim 1 , wherein the drawing the melt into the drawn glass fiber is accomplished continuously.

4. The method of claim 1 , wherein a temperature of the melt is from 1,050° C. to 1,200° C., and is above a glass liquidus temperature by from 10° C. to 200° C.

5. The method of claim 1 , wherein the glass composition comprises:
60 to 70% SiO 2 ,
15 to 30% Na 2 O,
5 to 15% K 2 O,
1 to 10% CaO, and
5 to 10% P 2 O 5 , based on a 100 wt % of the glass composition.

6. A bioactive glass composition comprising:
60 to 70% SiO 2 ,
15 to 30% Na 2 O,
5 to 15% K 2 O,
1 to 10% CaO, and
5 to 10% P 2 O 5 , based on a 100 wt % of the bioactive glass composition wherein the bioactive glass composition is free of Al 2 O 3 , MgO, or both.

7. The bioactive glass composition of claim 6 , further comprising a carrier in an amount of from 5 to 300 wt % by superaddition to the bioactive glass composition to form a bioactive glass formulation.

8. The bioactive glass composition of claim 6 , wherein the bioactive glass composition has a biocompatibility of at least one of:
a proliferation of a live cell line on a surface of the bioactive glass composition; or
a continuous cell number increase of from 0 to 7 days in proximity of the surface of the bioactive glass composition.

9. The method of claim 1 , wherein the glass composition is free of MgO.

10. The method of claim 1 , wherein the glass composition is free of Al 2 O 3 .

11. The method of claim 1 , wherein the glass composition is free of both Al 2 O 3 and MgO.

12. The method of claim 1 , wherein the glass composition is free of Al 2 O 3 and comprises 0.1 to 15% MgO, based on a 100 wt % of the glass composition.

13. The method of claim 1 , wherein the glass composition is free of MgO and comprises 0.1 to 10% Al 2 O 3 , based on a 100 wt % of the glass composition.

Assignees

• Corning Inc

Inventors

• Deng Huayun
• Fu Qiang
• Mauro John Christopher
• Snyder Michael Joshua

Classifications

• C03C3/097 Primary

  containing phosphorus, niobium or tantalum · CPC title

• A61K33/42

  Phosphorus; Compounds thereof · CPC title

• C03C4/0014

  Biodegradable glass · CPC title

• C03C4/0021

  for dental use · CPC title

• C03C13/00

  Fibre or filament compositions (manufacture of fibres or filaments C03B37/00) · CPC title