Method for neuromechanical and neuroelectromagnetic mitigation of limb pathology

Patent metadata

Field	Value
Publication number	US-11992307-B2
Application number	US-201816754351-A
Country	US
Kind code	B2
Filing date	Oct 9, 2018
Priority date	Oct 10, 2017
Publication date	May 28, 2024
Grant date	May 28, 2024

Abstract

A physiological feature of a subject is monitored by implanting a plurality of targets, such as magnets, and detecting at least one change in a physical property of the targets, followed by modifying a physiological feature of the subject in response to a change of state detected by the change in physical property detected in the targets. Cutaneous sensory feedback and proprioceptive feedback in a subject, as well as selective stimulation of axons or nerve fascicles of a neuron of a subject are provided.

First claim

What is claimed is:

1. A method for detecting a physical property of tissue for control of a wearable device, comprising:
implanting a plurality of targets at an individual muscle-tendon tissue;
employing an array of sensors to detect a magnetic field at each of the sensors of the array;
estimating a position and orientation of a magnetic dipole moment of each of at least two of the plurality of targets based on the detected magnetic fields; and
determining at least one state of the at least two targets relative to each other based upon the estimated position and orientation of the magnetic dipole moment of each of the at least two targets, wherein the state of the targets is indicative of a physical property, thereby detecting the physical property of the tissue and wherein the detected physical property is employed in control of a wearable device.

2. The method of claim 1 , wherein the targets are passive targets.

3. The method of claim 1 , wherein the targets are implanted in the tissue.

4. The method of claim 1 , wherein the state of the targets includes a change of state of the targets.

5. The method of claim 1 , wherein the physical property detected is a change in physical property of the tissue.

6. The method of claim 1 , wherein the state of the targets includes at least one of: the positions of the targets relative to each other or the orientations of the targets relative to each other.

7. The method of claim 1 , wherein the state of the targets includes at least one of: the distance of the targets from each other or a speed of the targets relative to each other.

8. The method of claim 1 , wherein the tissue is an individual muscle, and wherein the targets are a pair of targets spaced apart from each other, whereby contraction or relaxation of the muscle causes the targets to move closer to or further from each other, respectively.

9. The method of claim 8 , wherein the targets include a permanent magnetic material.

10. The method of claim 1 , wherein the array of sensors includes at least one member selected from the group consisting of a Hall effect sensor, a magnetoresistor, a magneto-inductive sensor, a fluxgate magnetometer, a superconducting quantum interference device magnetometer, and a passive electromagnetic coil.

11. The method of claim 1 , wherein a geomagnetic field is detected simultaneously.

12. The method of claim 1 , wherein the tissue is a tendon.

13. The method of claim 1 , wherein the targets include a coating of a biocompatible material.

14. The method of claim 13 , wherein the biocompatible material includes at least one member of the group consisting of a bioceramic, parylene, glass, silicone, titanium, and a biocompatible polymer.

15. The method of claim 1 , wherein the at least one state of the targets is detected by at least one member of the group consisting of a three-axis magnetometer; a two-axis magnetometer; and a combination of two single-axis magnetometers.

16. A device for detecting a physical property of tissue for control of a wearable device, comprising:
an array of sensors configured to detect a magnetic field from a plurality of targets at an individual muscle-tendon tissue; and
electronics configured to:
estimate a position and orientation of a magnetic dipole moment of each of at least two of the plurality of targets based on the detected magnetic field; and
determine at least one state of the at least two targets relative to each other based upon the estimated position and orientation of the magnetic dipole moment of each of the at least two targets, and
provide an indication of a physical property of the tissue based on the determined at least one state, wherein the physical property is employed in control of a wearable device.

17. The device of claim 16 , wherein the array of sensors is configured to detect targets that are passive targets.

18. The device of claim 16 , wherein the array of sensors is configured to detect targets that are implanted in the tissue.

19. The device of claim 16 , wherein the determined state of the targets includes a change of state of the targets.

20. The device of claim 16 , wherein the determined state of the targets includes at least one of: the positions of the targets relative to each other or the orientations of the targets relative to each other.

21. The device of claim 16 , wherein the determined state of the targets includes at least one of: the distance of the targets from each other or a speed of the targets relative to each other.

22. The device of claim 16 , wherein the determined state of the targets indicates contraction or relaxation of a muscle, the tissue being the muscle, the plurality of targets comprising a pair of targets spaced apart from each other, whereby contraction or relaxation of the muscle causes the pair of targets to move closer to or further from each other, respectively.

23. The device of claim 22 , wherein the array of sensors is configured to detect targets that include a permanent magnetic material.

24. A method for detecting a physical property of tissue for control of a wearable device, comprising:
implanting a plurality of targets at an individual muscle-tendon tissue;
employing an array of sensors to detect a magnetic field at each of the sensors of the array;
estimating a position of a magnetic dipole moment of each of at least two of the plurality of targets based on the detected magnetic fields; and
determining at least one state of the at least two targets relative to each other based upon the estimated position of the magnetic dipole moment of each of the at least two targets, wherein the state of the targets is indicative of a physical property, thereby detecting the physical property of the tissue and wherein the detected physical property is employed in control of a wearable device,
wherein the at least one state includes the positions of the at least two targets relative to each other.

Assignees

• Massachusetts Inst Technology

Inventors

• Herr Hugh M
• Taylor Cameron
• Clites Tyler

Classifications

• A61B5/1107 Primary

  Measuring contraction of parts of the body, e.g. organ or muscle · CPC title

• A61B5/05

  Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves (measuring movement of the entire body or parts thereof A61B5/11; detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof A61B5/24) · CPC title

• A61B5/4519

  Muscles (measuring muscular strength A61B5/224; using electromyography [EMG] A61B5/389) · CPC title

• A61B5/4523

  Tendons · CPC title

• A61B5/6811

  External prosthesis · CPC title