Methods and systems for high-throughput blood component collection

Patent metadata

Field	Value
Publication number	US-11980707-B2
Application number	US-202318103111-A
Country	US
Kind code	B2
Filing date	Jan 30, 2023
Priority date	Apr 21, 2017
Publication date	May 14, 2024
Grant date	May 14, 2024

Abstract

Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.

First claim

What is claimed is:

1. An apheresis system comprising:
a first pump configured to draw whole blood from a donor;
a second pump configured to add an anticoagulant from an anticoagulant source to the whole blood;
a blood separator configured to receive whole blood from the donor and separate the whole blood into a first blood component and a second blood component;
a collection container configured to receive the first blood component from the blood separator; and
a controller configured to control the blood separator, the first pump, and the second pump,
wherein the controller is configured to operate the blood separator, the first pump, and the second pump until a collected volume of the first blood component in the collection container equals a target volume for the first blood component,
wherein the controller is further configured to operate the blood separator, the first pump, and the second pump to return the second blood component to the donor;
a sensor in electrical communication with the controller, the sensor being disposed between the blood separator and the donor and configured to detect if the first blood component is present in a second stream exiting the blood separator, wherein the controller is configured to operate the blood separator, the first pump, and the second pump in an operational mode where the first pump is activated to draw whole blood from the donor and into the blood separator.

2. The apheresis system of claim 1 , wherein the blood separator includes a centrifuge that defines an internal cavity configured to receive a separation bladder having a first port configured to receive the whole blood and a second port configured to direct the first blood component via a first line connected to the collection container.

3. The apheresis system of claim 1 , wherein the first blood component predominantly comprises plasma and the second blood component predominantly comprises at least one of red blood cells or platelets.

4. The apheresis system of claim 1 , wherein the sensor is a first sensor and the apheresis system further comprises a second sensor in electrical communication with the controller, the second sensor being disposed between the blood separator and the collection container and configured to detect if the second blood component is present in a first stream exiting the blood separator, wherein the controller is configured to operate the blood separator, the first pump, and the second pump in an operational mode where a portion of the first blood component in the collection container is returned to the blood separator and drives the second blood component out of the blood separator towards the donor after the second sensor detects the second blood component in the first stream.

5. The apheresis system of claim 1 , wherein the controller is configured to operate the blood separator, the first pump, and the second pump in a first operational mode until the collected volume of the first blood component in the collection container equals the target volume for the first blood component and the controller is configured to operate the blood separator, the first pump, and the second pump in a second operational mode to return the second blood component to the donor, wherein the controller is configured to continuously operate the blood separator in the first operational mode and the second operational mode.

6. The apheresis system of claim 1 , further comprising a source of saline, wherein after the collected volume of the first blood component in the collection container equals the target volume for the first blood component, the controller is configured to operate the blood separator, the first pump, and the second pump to return the second blood component to the donor in a stream that further includes saline from the source of saline.

7. An apheresis system comprising:
a first pump configured to draw whole blood from a donor;
a second pump configured to add an anticoagulant from an anticoagulant source to the whole blood;
a blood separator configured to receive whole blood from the donor and separate the whole blood into a first blood component and a second blood component;
a collection container configured to receive the first blood component from the blood separator; and
a controller configured to control the blood separator, the first pump, and the second pump,
wherein the controller is configured to determine whether a collected volume of the first blood component equals a target volume for the first blood component,
the controller is configured to operate the blood separator, the first pump, and the second pump to return the second blood component to the donor; and
a sensor in electrical communication with the controller, the sensor being disposed between the blood separator and the donor and configured to detect if the first blood component is present in a second stream exiting the blood separator, wherein the controller is configured to operate the blood separator, the first pump, and the second pump in an operational mode where the first pump is activated to draw whole blood from the donor and into the blood separator.

8. The apheresis system of claim 7 , wherein the first blood component predominantly comprises plasma and the second blood component includes at least one of red blood cells or platelets.

9. The apheresis system of claim 7 , wherein the sensor is a first sensor and the apheresis system further comprises a second sensor in electrical communication with the controller, the second sensor being disposed between the blood separator and the collection container and configured to detect if the second blood component is present in a first stream exiting the blood separator, wherein the controller is configured to operate the blood separator, the first pump, and the second pump in an operational mode where a portion of the first blood component in the collection container is returned to the blood separator and drives the second blood component out of the blood separator towards the donor after the second sensor detects the second blood component in the first stream.

10. The apheresis system of claim 7 , wherein the controller is configured to operate the blood separator, the first pump, and the second pump in a first operational mode until the collected volume of the first blood component in the collection container equals the target volume for the first blood component and the controller is configured to operate the blood separator, the first pump, and the second pump in a second operational mode to return the second blood component to the donor, wherein the controller is configured to continuously operate the blood separator in the first operational mode and the second operational mode.

11. The apheresis system of claim 7 , further comprising a source of saline and after the collected volume of the first blood component in the collection container equals the target volume for the first blood component, the controller is configured to operate the blood separator, the first pump, and the second pump to return the second blood component to the donor in a stream that further includes saline from the source of saline.

12. A method for collecting a blood component through apheresis, the method comprising:
determining a target volume of a first blood component;
drawing whole blood from a donor into a centrifuge;
adding an anticoagulant into the whole blood from an anticoagulant source;
spinning the centrifuge at a first speed to separate the whole blood into the first blood component and a second blood component;
directing the first blood component into a container and detecting by a first sensor if the second blood component is pre

Assignees

• Terumo Bct Inc

Inventors

• Felt Thomas J
• Hlavinka Dennis J
• Holmes Brian M

Classifications

• A61M1/3696 Primary

  with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation · CPC title

• A61M1/024

  Means for controlling the quantity of transfused blood, e.g. by weighing the container and automatic stopping of the transfusion after reaching a determined amount · CPC title

• A61M1/0272

  Apparatus for treatment of blood or blood constituents prior to or for conservation, e.g. freezing, drying or centrifuging · CPC title

• A61M1/304

  Treatment chamber used as reservoir, e.g. centrifuge bowl or filter with movable membrane · CPC title

• A61M1/3496

  Plasmapheresis; Leucopheresis; Lymphopheresis (A61M1/3472 takes precedence) · CPC title