Ring-in-ring complexes exhibiting tunable multicolor photoluminescence
US-2023322781-A1 · Oct 12, 2023 · US
Mechanical-bond-induced exciplex fluorescence
US11977028B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11977028-B2 |
| Application number | US-202117301823-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 15, 2021 |
| Priority date | Apr 15, 2020 |
| Publication date | May 7, 2024 |
| Grant date | May 7, 2024 |
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Abstract
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Disclosed herein are methods for live-cell imaging, compositions for performing the live cell imaging, and methods for making the composition. The method may comprise contacting a cell with an effective amount of a catenane, irradiating the cell, and detecting exciplex emission from the catenane within the cell. The catenane may comprise two mechanically interlocked macrocycles, each of the two macrocycles comprise an aromatic fluorophore subunit, and the aromatic fluorophores are arranged in a face-to-face [π . . . π] stack allowing for the exciplex emission.
First claim
Opening claim text (preview).
We claim: 1. A method for live-cell imaging, the method comprising: (a) contacting a cell with an effective amount of a catenane; (b) irradiating the cell; (c) detecting exciplex emission from the catenane within the cell, wherein the catenane comprises two mechanically interlocked macrocycles, each of the two macrocycles comprise an aromatic fluorophore subunit, and wherein the aromatic fluorophores are arranged in a face-to-face [π . . . π] stack allowing for the exciplex emission. 2. The method of claim 1 , wherein the aromatic fluorophore comprises an anthracene subunit. 3. The method of claim 2 , wherein the aromatic fluorophore comprises an anthracene-bypyridine subunit. 4. The method of claim 3 , wherein the anthracene-bypyridine subunit is a 2,6-anthracene-bypyridine subunits. 5. The method of claim 1 , wherein the effective amount of the catenane is less than 10×10 −6 M. 6. The method of claim 1 , wherein the detected emission has a wavelength greater than 600 nm. 7. The method of claim 1 , wherein the cell is irradiated with a wavelength less than 500 nm. 8. The method of claim 1 , wherein the catenane is octacationic. 9. The method of claim 1 , wherein each of the two macrocycles comprise two aromatic fluorophore subunits and the four aromatic fluorophore subunits are arranged in a face-to-face [π . . . π] stack. 10. The method of claim 1 , wherein the method is performed in vitro. 11. The method of claim 1 , wherein the catenane is 2,6 AnHC 8+.
Assignees
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Classifications
- G01N21/6486Primary
Measuring fluorescence of biological material, e.g. DNA, RNA, cells (G01N21/6428 takes precedence) · CPC title
with measurement of decay time, time resolved fluorescence · CPC title
Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" (in vivo A61B5/00; immunoassay G01N33/53) · CPC title
- G01N33/502Primary
for testing non-proliferative effects · CPC title
with fluorescent label · CPC title
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- What does patent US11977028B2 cover?
- Disclosed herein are methods for live-cell imaging, compositions for performing the live cell imaging, and methods for making the composition. The method may comprise contacting a cell with an effective amount of a catenane, irradiating the cell, and detecting exciplex emission from the catenane within the cell. The catenane may comprise two mechanically interlocked macrocycles, each of the two…
- Who is the assignee on this patent?
- Univ Northwestern, King Abdulaziz City For Science And Tech Kacst
- What technology area does this patent fall under?
- Primary CPC classification G01N21/6486. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue May 07 2024 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 6 related publications on this page (citations in our corpus or others sharing the same primary CPC).