Method and system for solventless calibration of volatile or semi-volatile compounds

Patent metadata

Field	Value
Publication number	US-11975304-B2
Application number	US-202117356795-A
Country	US
Kind code	B2
Filing date	Jun 24, 2021
Priority date	Feb 23, 2018
Publication date	May 7, 2024
Grant date	May 7, 2024

Abstract

A system for solventless calibration of volatile or semi-volatile compounds and methods thereof. The system includes a fluid path having a first end configured to be operably coupled to a fluid source and a second end configured to be operably coupled to the analytical instrument. A solid sorbent is disposed along the fluid path and is configured to absorb an analyte. The flow of fluid along the fluid path from the first end to the second end causes absorbed analyte to be desorbed from the solid sorbent at a desired concentration to the instrument.

First claim

What is claimed is:

1. A microcalibrator for solventless calibration of an analytical instrument, the microcalibrator comprising:
a fluid path having a first end configured to be operably coupled to a fluid source and a second end configured to be operably coupled to the analytical instrument; and
a first solid sorbent disposed along the fluid path, the first solid sorbent configured to absorb an analyte at a first concentration; and
a second solid sorbent disposed along the fluid path, the second solid sorbent configured to absorb the analyte at a second concentration, wherein the first solid sorbent and the second solid sorbent are positioned in parallel along the fluid path;
wherein flow of the analyte along the fluid path from the first end causes the analyte to absorb onto the first solid sorbet and the second solid sorbent and wherein flow of a fluid along the fluid path from the first end to the second end causes absorbed analyte to be desorbed from the first solid sorbent, the second solid sorbent, or both, to establish at least a two-point calibration curve.

2. The microcalibrator of claim 1 , further comprising:
a hub for receiving an analyte source having the analyte therein, the hub being fluidically coupled to the fluid path.

3. The microcalibrator of claim 2 , wherein the hub is configured to engage a pierceable septum of the analyte source.

4. The microcalibrator of claim 1 , further comprising:
a hotplate operably coupled to the first and second solid sorbents.

5. The microcalibrator of claim 1 , wherein the first solid sorbent and the second solid sorbent are separately selected from the group consisting of graphitized carbon black, activated carbon, a porous polymer, or a xerogel.

6. The microcalibrator of claim 1 , further comprising:
a carbon trap along the fluid path.

7. The microcalibrator of claim 1 , further comprising:
a controller configured to operate a flow of fluid along the fluid path.

8. The microcalibrator of claim 1 , further comprising:
a valve configured to divert fluid flow between the first solids sorbent and the second solid sorbent.

9. The microcalibrator of claim 1 , wherein the fluid path, the first solid sorbent, the second solid sorbent, or a combination thereof are configured to be heated for facilitating desorption of low vapor pressure analytes.

Assignees

• Us Gov Air Force
• Us Air Force

Inventors

• Rubenstein H Mitchell
• Lewis Patrick

Classifications

• B01J20/103 Primary

  comprising silica · CPC title

• B01J20/262

  obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. obtained by polycondensation (macromolecular compounds obtained otherwise than by reactions only involving unsaturated carbon-to-carbon bonds per se C08G) · CPC title

• B01J20/282

  Porous sorbents (ion exchange B01J39/00 - B01J41/00) · CPC title

• B01J20/283

  based on silica · CPC title

• B01J20/285

  based on polymers · CPC title