Methods and systems for determining fluid administration

Patent metadata

Field	Value
Publication number	US-11975175-B2
Application number	US-201916417885-A
Country	US
Kind code	B2
Filing date	May 21, 2019
Priority date	Feb 4, 2015
Publication date	May 7, 2024
Grant date	May 7, 2024

Abstract

Methods and systems are provided for determining fluid administration. The system may determine fluid administration based on the fluid responsiveness and regional oxygen saturation of a subject. The system may receive the fluid responsiveness and regional oxygen saturation from external sources or may determine one or both based on received physiological signals. In some embodiments, the system may determine whether to administer fluid based on the fluid responsiveness and regional oxygen saturation. In some embodiments, the system may determine the amount of fluid to administer based on the fluid responsiveness and regional oxygen saturation. In some embodiments, the system may determine the effectiveness of fluid administration. In some embodiments, the system may provide an indication of the determined fluid administration so that a care-giver can implement the appropriate fluid administration. In some embodiments, the system may control the fluid administration based on its determination.

First claim

What is claimed:

1. A system comprising:
a regional oximeter configured to generate a signal indicative of regional oxygen saturation of a subject;
a user interface; and
processor circuitry configured to:
receive the signal generated by the regional oximeter,
determine a value indicative of fluid responsiveness of the subject based on the signal, wherein the value indicative of fluid responsiveness of the subject is determined based on a degree of variation of a photoplethysmography (PPG) waveform associated with the signal,
determine that fluid should be administered to the subject or an amount of fluid to administer to the subject based on the value indicative of fluid responsiveness; and
cause the user interface to output one or more of an indication to administer fluid to the subject or an indication of the amount of fluid to administer to the subject based on the determination that fluid should be administered to the subject or the determination of the amount of fluid to administer to the subject.

2. The system of claim 1 , wherein the regional oximeter comprises:
a light source configured to generate a light signal;
a first light detector positioned a first distance from the light source and configured to receive the light signal after the light signal passes through tissue of the subject; and
a second light detector positioned a second distance from the light source and configured to receive the light signal after the light signal passes through tissue of the subject, the second distance being greater than the first distance.

3. The system of claim 1 , wherein the processor circuitry is configured to determine the value indicative of fluid responsiveness of the subject based on the signal by at least:
determining a regional tissue oxygen saturation value based on the signal, and
determining the value indicative of fluid responsiveness of the subject based on the regional tissue oxygen saturation value.

4. The system of claim 1 , wherein the processor circuitry is configured to determine that fluid should be administered to the subject based on the value indicative of fluid responsiveness, wherein the processor circuitry is configured to determine that fluid should be administered at least:
determining a regional tissue oxygen saturation value based on the signal,
determining the regional tissue oxygen saturation value is less than a first threshold,
determining the value indicative of fluid responsiveness is greater than a second threshold, and
determining that fluid should be administered to the subject based on the determination that the regional tissue oxygen saturation value is less than the first threshold and the value indicative of fluid responsiveness is greater than the second threshold.

5. The system of claim 4 , wherein the first threshold is indicative of adequate perfusion of a region of the subject sensed by the regional oximeter.

6. The system of claim 1 , wherein the processor circuitry is configured to determine that fluid should be administered to the subject based on the value indicative of fluid responsiveness, wherein the processor circuitry is configured to determine that fluid should be administered to the subject by at least:
determining the value indicative of fluid responsiveness is not greater than a threshold, and
determining that fluid should not be administered to the subject based on the determination that the value indicative of fluid responsiveness is not greater than the threshold.

7. The system of claim 1 , wherein the processor circuitry is configured to determine the amount of fluid to administer to the subject based on the value indicative of fluid responsiveness, wherein the processor circuitry is configured to determine the amount of fluid to administer to the subject by at least:
determining a regional tissue oxygen saturation value based on the signal,
determining the regional tissue oxygen saturation value is greater than a first threshold,
determining the value indicative of fluid responsiveness is greater than a second threshold, and
reducing a volume of fluid administered to the subject based on determining the regional tissue oxygen saturation value is greater than the first threshold and the value indicative of fluid responsiveness is greater than the second threshold.

8. The system of claim 7 , wherein the second threshold corresponds to an improvement in cardiac output of the subject by at least 15%.

9. The system of claim 1 , wherein the processor circuitry is configured to determine the amount of fluid to administer to the subject based on the value indicative of fluid responsiveness, wherein the processor circuitry is configured to determine the amount of fluid to administer to the subject by at least:
determining the value indicative of fluid responsiveness is not greater than a threshold, and
reducing a volume of fluid administered to the subject based on determining the value indicative of fluid responsiveness is not greater than the threshold.

10. The system of claim 1 , wherein the processor circuitry is configured to determine the amount of fluid to administer to the subject based on the value indicative of fluid responsiveness, wherein the processor circuitry is configured to determine the amount of fluid to administer to the subject by at least:
determining a regional tissue oxygen saturation value based on the signal,
determining the regional tissue oxygen saturation value is less than a first threshold,
determining the value indicative of fluid responsiveness is greater than a second threshold, and
increasing a volume of fluid administered to the subject based on determining the regional tissue oxygen saturation value is less than the first threshold and the value indicative of fluid responsiveness is greater than the second threshold.

11. The system of claim 1 , wherein the processor circuitry is configured to determine the amount of fluid to administer to the subject based on the value indicative of fluid responsiveness, wherein the processor circuitry is configured to determine the amount of fluid to administer to the subject by at least controlling a fluid administration device to deliver fluid to the subject until the value indicative of fluid responsiveness is greater than a threshold.

12. The system of claim 1 , further comprising a fluid administration device configured to administer fluid to the subject based on the determination by the processor circuitry to administer fluid to the subject.

13. The system of claim 1 , wherein the user interface comprises a display configured to display the value indicative of fluid responsiveness and an indication of fluid administration upon the determination by the processor circuitry that fluid should be administered to the subject.

14. The system of claim 1 , wherein the processor circuitry is configured to:
determine that fluid should be administered to the subject based on the value indicative of fluid responsiveness,
in response to the determination that fluid should be administered to the subject, determine an amount of fluid to administer to the subject based on the value indicative of fluid responsiveness; and
cause the user interface to output an indication of the amount of fluid to administer to the subject based on the determination of the amount of fluid to administer to the subject.

15. A method comprising:
receiving, by processor circuitry, a signal generated by a regional oxygen saturation sensor, the signal being indicative of regional oxygen saturation of a subject;
determining, by the processor circuitry, a value indicative of fluid responsiv

Assignees

• Covidien Lp

Inventors

• Doyle Peter
• Addison Paul S
• Watson James N

Classifications

• A61M5/1723 Primary

  using feedback of body parameters, e.g. blood-sugar, pressure (measurement of body parameters A61B5/00) · CPC title

• A61B5/08

  Measuring devices for evaluating the respiratory organs · CPC title

• A61B5/14551

  for measuring blood gases · CPC title

• A61B5/4848

  Monitoring or testing the effects of treatment, e.g. of medication · CPC title

• A61B5/4875

  Hydration status, fluid retention of the body · CPC title