Automatic analysis device

Patent metadata

Field	Value
Publication number	US-11971426-B2
Application number	US-201916646824-A
Country	US
Kind code	B2
Filing date	Jan 23, 2019
Priority date	Mar 16, 2018
Publication date	Apr 30, 2024
Grant date	Apr 30, 2024

Abstract

An automatic analysis device that avoids carryover and prevents deterioration of analysis performance without controlling reaction cell position is provided with: a reaction cell in which a sample and a reagent are mixed and allowed to react; a light source that radiates light onto the mixed liquid of the sample and the reagent; a detector that detects the light radiated from the light source; and a cleaning mechanism that cleans the reaction cell. The cleaning mechanism includes an intake nozzle that draws in liquid from the reaction cell and a discharge nozzle that discharges the liquid into the reaction cell; the intake nozzle and the discharge nozzle can move vertically; and the intake nozzle is cleaned by lowering the intake nozzle into the reaction cell, in which a cleaning liquid or cleaning water have been accumulated, without drawing in the cleaning liquid or the cleaning water.

First claim

The invention claimed is:

1. An automatic analysis device comprising:
a rotatable reaction disk on which a plurality of reaction cells, in each of which a mixed liquid including a sample and a reagent that are mixed and have been allowed to react, are disposed on a circumference;
a light source configured to radiate light onto the mixed liquid of the sample and the reagent, the mixed liquid being dispensed into the plurality of reaction cells disposed on the reaction disk;
a detector configured to detect the light radiated from the light source;
a cleaning mechanism including a plurality of cleaning nozzles configured to clean the plurality of reaction cells; and
a control unit, wherein
the control unit controls the cleaning mechanism and the reaction disk to perform:
an operation of lowering one cleaning nozzle of the plurality of cleaning nozzles in the cleaning mechanism toward a first reaction cell of the plurality of reaction cells, and the one cleaning nozzle discharging and accumulating a cleaning liquid or cleaning water into the first reaction cell,
an operation of rotating the reaction disk after the accumulation, and
an operation of, after the rotation, lowering another cleaning nozzle of the plurality of cleaning nozzles in the cleaning mechanism toward the first reaction cell without making the another cleaning nozzle draw in the cleaning liquid or cleaning water, and immersing the another cleaning nozzle in the cleaning liquid or cleaning water that is accumulated in the first reaction cell by the one cleaning nozzle,

wherein each of the plurality of cleaning nozzles includes an intake nozzle configured to draw in the cleaning liquid or cleaning water from the first reaction cell and a discharge nozzle disposed in contact with the intake nozzle and configured to discharge the cleaning liquid or cleaning water into the first reaction cell, and a lower end of the intake nozzle extends beyond a lower end of the discharge nozzle, and
the cleaning liquid is an alkaline cleaning liquid, and
wherein the control unit controls the cleaning mechanism and the reaction disk differently based on whether the alkaline cleaning liquid or the cleaning water is being discharged, such that the intake nozzle is disposed inside of the first reaction cell and in contact with a bottom surface of the first reaction cell when discharging of the alkaline cleaning liquid begins and the discharging of the alkaline cleaning liquid continues while the intake nozzle is raised away from the bottom surface until the intake nozzle reaches an overflow intake height of the first reaction cell, and the intake nozzle is disposed inside of the first reaction cell and above the bottom surface of the first reaction cell during discharging of the cleaning water and the intake nozzle is lowered into the first reaction cell and in contact with the bottom surface of the first reaction cell only after the discharging of the cleaning water has been completed.

2. The automatic analysis device according to claim 1 , wherein
the control unit controls to perform cleaning of the one cleaning nozzle when an analysis of the sample is completed in a state in which cleaning of the first reaction cell is not completed.

3. The automatic analysis device according to claim 2 , wherein
the control unit
controls an operation of the cleaning mechanism such that:
when the mixed liquid is accommodated in the first reaction cell at a start of the analysis of the sample, the intake nozzle draws in the mixed liquid, after the mixed liquid is drawn in, the discharge nozzle discharges and accumulates the cleaning liquid or cleaning water in the first reaction cell, and the intake nozzle is lowered while drawing in the accumulated cleaning liquid or cleaning water, thus cleaning the first reaction cell, and
causes, after the cleaning of the first reaction cell, the discharge nozzle to discharge and accumulate the cleaning liquid or cleaning water again in the first reaction cell to perform cleaning of the one cleaning nozzle.

4. The automatic analysis device according to claim 1 , wherein
the control unit controls an operation of the cleaning mechanism to clean the first reaction cell such that the one cleaning nozzle of the cleaning mechanism is lowered toward the first reaction cell in which the cleaning liquid or cleaning water is accumulated, and the one cleaning nozzle draws in the cleaning liquid or cleaning water while being lowered.

5. The automatic analysis device according to claim 4 , wherein
the reagent that is not able to be cleaned with cleaning water is a reagent containing a component of protein.

6. The automatic analysis device according to claim 1 , wherein
the control unit controls to perform the cleaning of the one cleaning nozzle when the reagent is not able to be cleaned with the cleaning water.

7. The automatic analysis device according to claim 1 , wherein
the control unit controls to write information on whether the analysis of the sample is completed while the cleaning of the first reaction cell is completed into the nonvolatile memory.

8. The automatic analysis device according to claim 1 , wherein
independently of each operation for performing cleaning of the cleaning nozzle,
the control unit cleans each of the plurality of reaction cells by repeating the operation of lowering or elevating the cleaning nozzle, and discharging or drawing in the cleaning liquid or cleaning water by the cleaning nozzle.

9. The automatic analysis device according to claim 1 , wherein the control unit performs an operation of storing a flag in a nonvolatile memory indicating whether cleaning of each of the plurality of cleaning nozzles is required.

10. A cleaning method to be performed in an automatic analysis device including:
a rotatable reaction disk on which a plurality of reaction cells, in each of which a mixed liquid including a sample and a reagent that are mixed and have been allowed to react, are disposed on a circumference;
a cleaning mechanism including a plurality of cleaning nozzles configured to clean the plurality of reaction cells; and
a control unit, the method comprising:
the control unit controlling the cleaning mechanism and the reaction disk to perform
an operation of lowering one cleaning nozzle of the plurality of cleaning nozzles in the cleaning mechanism toward a first reaction cell of the plurality of reaction cells, and the one cleaning nozzle discharging and accumulating a cleaning liquid or cleaning water into the first reaction cell;
an operation of rotating the reaction disk after the accumulation;
an operation of, after the rotation, lowering another cleaning nozzle of the plurality of cleaning nozzles in the cleaning mechanism toward the first reaction cell without making the another cleaning nozzle draw in the cleaning liquid or cleaning water, and immersing the another cleaning nozzle in the cleaning liquid or cleaning water that is accumulated in the first reaction cell by the one cleaning nozzle, so as to clean the another cleaning nozzle,

wherein each of the plurality of cleaning nozzles includes an intake nozzle configured to draw in the cleaning liquid or cleaning water from the first reaction cell and a discharge nozzle disposed in contact with the intake nozzle and configured to discharge the cleaning liquid or cleaning water into the first reaction cell, and a lower end of the intake nozzle extends beyond a lower end of the discharge nozzle,
the cleaning liquid is an alkaline cleaning liquid, and
wherein the control unit controls the cleaning mechanism and the reaction disk differently based on whether the alkaline cleaning liquid or the cleaning water is being discharged, such that

Assignees

• Hitachi High Tech Corp

Inventors

• Konishi Rei
• Sasaki Nobuhiko
• Iijima Masahiko

Classifications

• G01N35/1004 Primary

  Cleaning sample transfer devices · CPC title

• B01L13/00

  Cleaning or rinsing apparatus · CPC title

• G01N21/11 Primary

  Filling or emptying of cuvettes · CPC title

• G01N21/253

  for batch operation, i.e. multisample apparatus (analytical automats G01N35/00) · CPC title

• G01N21/47

  Scattering, i.e. diffuse reflection (G01N21/25, G01N21/41 take precedence {G01N21/55 takes precedence}) · CPC title