Monomers capable of dimerizing in an aqueous solution, and methods of using same

Patent metadata

Field	Value
Publication number	US-11970448-B2
Application number	US-202016929528-A
Country	US
Kind code	B2
Filing date	Jul 15, 2020
Priority date	Apr 7, 2011
Publication date	Apr 30, 2024
Grant date	Apr 30, 2024

Abstract

Described herein are monomers capable of forming a biologically useful multimer when in contact with one, two, three or more other monomers in an aqueous media. In one aspect, such monomers may be capable of binding to another monomer in an aqueous media (e.g. in vivo) to form a multimer, (e.g. a dimer). Contemplated monomers may include a ligand moiety, a linker element, and a connector element that joins the ligand moiety and the linker element. In an aqueous media, such contemplated monomers may join together via each linker element and may thus be capable of modulating one or more biomolecules substantially simultaneously, e.g., modulate two or more binding domains on a protein or on different proteins.

First claim

What is claimed is:

1. A therapeutic composition comprising a first monomer selected from the group consisting of:

and
a second monomer selected from the group consisting of:

and
pharmaceutically acceptable salts, stereoisomers, or hydrates thereof.

2. The therapeutic composition of claim 1 , wherein the first monomer is

and the second monomer is

3. A therapeutic composition comprising a first monomer selected from the group consisting of:

and a second monomer selected from the group consisting of:

and
pharmaceutically acceptable salts, stereoisomers, or hydrates thereof.

Assignees

• Univ Cornell
• Purdue Research Foundation

Inventors

• Barany Francis
• Pingle Maneesh
• Bergstrom Donald E
• Giardina Sarah F
• Arnold Lee Daniel

Classifications

• C07D211/26 Primary

  with hydrocarbon radicals, substituted by nitrogen atoms · CPC title

• C07D405/06

  linked by a carbon chain containing only aliphatic carbon atoms · CPC title

• C07D409/06

  linked by a carbon chain containing only aliphatic carbon atoms · CPC title

• C07D491/107

  with only one oxygen atom as ring hetero atom in the oxygen-containing ring · CPC title

• C07F5/025

  Boronic and borinic acid compounds · CPC title