Passive, gravity-driven system for treatment of an effluent in a diagnostic system

Patent metadata

Field	Value
Publication number	US-11970406-B2
Application number	US-202217836850-A
Country	US
Kind code	B2
Filing date	Jun 9, 2022
Priority date	Dec 19, 2016
Publication date	Apr 30, 2024
Grant date	Apr 30, 2024

Abstract

Automated systems to make target compounds from slide stainer waste streams inactive utilizing advanced oxidation processes are described herein. Advanced oxidation processes are promoted by UV irradiation and further accelerated by use of radical initiators, such as hydrogen peroxide. The automated systems further include mechanisms for segregating components of the waste streams.

First claim

What is claimed is:

1. A passive, gravity-driven treatment system for treatment of a waste stream exiting a diagnostic system, wherein the gravity-driven treatment system comprises:
(a) a homogenizing reservoir fluidically connected to the diagnostic system for receiving a radical initiator and the waste stream exiting the diagnostic system, wherein the waste stream comprises a set of fluid components comprising one or more target compounds, wherein a residence time of each fluid component of the set of fluid components in the homogenizing reservoir is sufficient for promoting a substantially even mixing of the set of fluid components to form a target effluent at or near a first outlet of the homogenizing reservoir;
(b) a radical generating reservoir, wherein the target effluent is routed from the first outlet of the homogenizing reservoir to the radical generating reservoir via a channel, wherein gravity facilitates flow of the target effluent from the homogenizing reservoir to the radical generating reservoir;
(c) a radical generator coupled to the radical generating reservoir, wherein when the radical initiator is exposed to the radical generator a detectable concentration of the one or more target compounds in the set of fluid components is reduced to provide a treated effluent; and
(d) a first disposal unit fluidically coupled to the radical generating reservoir, wherein the first disposal unit receives the treated effluent exiting from a waste outlet of the radical generating reservoir.

2. The system of claim 1 , wherein the first disposal unit is configured such that the treated effluent is not flowed to the diagnostic system.

3. The system of claim 1 , wherein the set of fluid components comprise an oil component and an aqueous component, wherein the oil component rises and floats above the aqueous component when in the homogenizing reservoir.

4. The system of claim 3 , further comprising a second disposal unit for receiving the oil component draining from an oil waste outlet of the homogenizing reservoir.

5. The system of claim 4 , wherein the draining of the oil component is facilitated by gravity.

6. The system of claim 1 , wherein the set of fluid components further comprises a biofilm or a partially dried sludge.

7. The system of claim 1 , wherein the one or more target compounds comprises 3,3′-diaminobenzidine (DAB).

8. The system of claim 1 , wherein a drain valve is disposed at a base of the homogenizing reservoir.

9. The system of claim 1 , wherein the radical initiator comprises at least one of an ultraviolet (“UV”) peroxide photoinitiator, a thermal peroxide initiator, an azo radical initiator, a nitroxide radical initiator, an organic photosensitizer, or an inorganic semiconductor nanomaterial.

10. The system of claim 1 , wherein the radical generator comprises a UV irradiation source.

11. The system of claim 1 , wherein the radical generator is disposed inside the radical generating reservoir so as to form an in-line flow-through UV irradiation system.

12. A passive, gravity-driven treatment system for treatment of a waste stream exiting a diagnostic system, wherein the gravity-driven treatment system comprises:
(a) a homogenizing reservoir fluidically coupled to the diagnostic system for receiving a radical initiator and the waste stream exiting the diagnostic system, wherein a target effluent formed at or near a first outlet of the homogenizing reservoir comprises at least one target compound;
(b) a radical generating reservoir, wherein the target effluent is routed from the first outlet of the homogenizing reservoir to the radical generating reservoir via a channel, wherein gravity facilitates flow of the target effluent from the homogenizing reservoir to the radical generating reservoir;
(c) a radical generator coupled to the radical generating reservoir, wherein when the radical initiator is exposed to the radical generator a detectable concentration of the at least one target compound in the target effluent is reduced to provide a treated effluent; and
(d) a first disposal unit fluidically coupled to the radical generating reservoir, wherein the first disposal unit receives the treated effluent exiting from a waste outlet of the radical generating reservoir, and wherein the first disposal unit is configured such that the treated effluent is not flowed to the diagnostic system.

13. The system of claim 12 , wherein the radical generator is configured to irradiate the target effluent while the target effluent is disposed in the radical generating reservoir and promote advanced oxidation processes (AOPs) that breakdown the at least one target compound.

14. The system of claim 12 , wherein the at least one target compound comprises 3,3′-diaminobenzidine (DAB).

15. The system of claim 12 , wherein the radical generator comprises a UV irradiation source.

16. The system of claim 12 , wherein the radical generator is disposed inside the radical generating reservoir so as to form an in-line flow-through UV irradiation system.

17. A passive, gravity-driven treatment system, operatively coupled to an automated slide staining apparatus, for treatment of a waste stream exiting the automated slide staining apparatus, wherein the system comprises:
(a) a homogenizing reservoir fluidically coupled to the automated slide staining apparatus for receiving the waste stream and a radical initiator, wherein the waste stream includes (i) an oil-phase fluid component, and (ii) an aqueous fluid component comprising at least one target compound, wherein the oil-phase fluid component rises and floats above the aqueous fluid component when in the homogenizing reservoir so as to form an upper layer of oil effluent and a lower layer of target effluent, wherein the radical initiator is disposed in the target effluent;
(b) a radical generating reservoir fluidly connected to the homogenizing reservoir;
(c) a radical generator coupled to the radical generating reservoir, wherein the radical generator is configured to irradiate the target effluent while the target effluent is disposed in the radical generating reservoir such that a detectable concentration of the at least one target compound in the target effluent is reduced to provide a treated effluent; and
(d) a first disposal unit for receiving the treated effluent exiting from a waste outlet of the radical generating reservoir, and wherein the first disposal unit is configured such that the treated effluent is not flowed to the automated slide staining apparatus.

18. The system of claim 17 , further comprising a second disposal unit for receiving the oil effluent exiting from an oil waste outlet of the homogenizing reservoir.

19. The system of claim 17 , wherein the radical initiator comprises at least one of an ultraviolet (“UV”) peroxide photoinitiator, a thermal peroxide initiator, an azo radical initiator, a nitroxide radical initiator, an organic photosensitizer, or a n inorganic semiconductor nanomaterial.

20. The system of claim 17 , wherein the radical generator comprises a UV irradiation source.

Assignees

• Ventana Med Syst Inc

Inventors

• Crum Nathan
• Jakubowski Joseph M
• Kosmeder Ii Jerome W
• May Eric
• Otter Michael
• Shingler Taylor J
• Stevens Benjamin C

Classifications

• C02F1/325 Primary

  Irradiation devices or lamp constructions · CPC title

• C02F1/32

  with ultraviolet light · CPC title

• C02F1/722

  Oxidation by peroxides · CPC title

• G01N1/31 Primary

  Apparatus therefor · CPC title

• G01N35/00029

  provided with flat sample substrates, e.g. slides (G01N35/028 takes precedence) · CPC title