Carbon-based material vibrator, a sensor element having the same, and a biological substance detection device having the same

Patent metadata

Field	Value
Publication number	US-11965857-B2
Application number	US-202117222324-A
Country	US
Kind code	B2
Filing date	Apr 5, 2021
Priority date	Oct 5, 2018
Publication date	Apr 23, 2024
Grant date	Apr 23, 2024

Abstract

A vibrator that is capable of vibrating without using an electrode and has good detection sensitivity is provided. A carbon-based material vibrator for vibration by light irradiation has a biological substance or a substance capable of identifying a biological substance immobilized on the vibrator. The vibrator may not include a counter electrode for applying a voltage to the vibrator. The carbon-based material may be graphite. A thermal conductivity λ1 in a plane direction of the carbon-based material is 100 times or more than a thermal conductivity λ2 in a thickness direction of the carbon-based material.

First claim

The invention claimed is:

1. A carbon-based material vibrator for vibration by light irradiation, wherein a biological substance or a substance capable of identifying a biological substance is immobilized on the vibrator.

2. The carbon-based material vibrator according to claim 1 , wherein the carbon-based material vibrator does not comprise a counter electrode for applying a voltage to the carbon-based material vibrator.

3. The carbon-based material vibrator according to claim 1 , wherein the carbon-based material is graphite.

4. The carbon-based material vibrator according to claim 3 , wherein the graphite has a mosaic spread of 0.1° or more to 3.0° or less.

5. The carbon-based material vibrator according to claim 1 , wherein a thermal conductivity λ1 in a plane direction of the carbon-based material is 100 times or more than a thermal conductivity λ2 in a thickness direction of the carbon-based material.

6. A sensor element comprising the carbon-based material vibrator according to claim 1 and a holder.

7. The sensor element according to claim 6 , further comprising a microchannel.

8. A biological substance detector comprising:
the carbon-based material vibrator according to claim 1 ;
a holder to hold the carbon-based material vibrator;
a microchannel through which a specimen flows into the carbon-based material vibrator;
a pump light source irradiating the carbon-based material vibrator with a pump light to vibrate the carbon-based material vibrator;
a probe light source irradiating the carbon-based material vibrator vibrated by the pump light with a probe light; and
a detector measuring a vibration displacement of the carbon-based material vibrator on a basis of a reflectance of a probe light reflected by the carbon-based material vibrator to detect a biological substance.

9. The carbon-based material vibrator according to claim 1 , wherein the carbon-based material has a concentration of 2.0 g/cm 3 or more and 2.26 g/cm 3 or less.

10. The carbon-based material vibrator according to claim 1 , wherein when the carbon-based material is subjected to laser Raman spectrometry, the ratio of the intensity I(D) of a D band caused by an amorphous carbon structure appearing in 1575-1600 cm −1 to the intensity I(G) of a G band caused by a graphite structure appearing in 1350-1360 cm −1 is 0 or more to 0.5 or less.

Assignees

• Kaneka Corp
• Univ Osaka

Inventors

• Murashima Kensuke
• Murakami Mutsuaki
• Ogi Hirotsugu
• Kusakabe Koichi

Classifications

• G01N29/12 Primary

  by measuring frequency or resonance of acoustic waves {(measuring frequency or resonant frequency of mechanical vibrations or acoustic waves in general G01H1/06, G01H3/04, G01H13/00; acoustic resonators G10K11/04; vibration or shock testing of structures G01M7/00)} · CPC title

• G01N29/2418

  using optoacoustic interaction with the material, e.g. laser radiation, photoacoustics (photoacoustic cells G01N21/1702; measuring characteristics of vibrations by using radiation-sensitive means G01H9/00; acousto-optical conversion techniques for short-range imaging G01S15/8965; sound-producing devices using laser bundle G10K15/046) · CPC title

• G01N33/483 Primary

  Physical analysis of biological material · CPC title

• G01N2291/0256

  Adsorption, desorption, surface mass change, e.g. on biosensors · CPC title

• G01N29/4418

  with a model, e.g. best-fit, regression analysis · CPC title