Etched non-porous particles and method of producing thereof

Patent metadata

Field	Value
Publication number	US-11964874-B2
Application number	US-202117234352-A
Country	US
Kind code	B2
Filing date	Apr 19, 2021
Priority date	Jun 9, 2020
Publication date	Apr 23, 2024
Grant date	Apr 23, 2024

Abstract

There is disclosed a method of producing etched non-porous particles. The method includes, in some examples, coating a non-porous particle with a hydrophilic polymer and treating the coated particle with acid or base. Also provided is etched non-porous particles capable of separating a variety of analytes, including biomolecules.

First claim

What is claimed is:

1. A particle comprising:
a non-porous core with an etched surface;
a layer comprising an etched surface, the layer at least partially coating the non-porous core with at least one material chosen from a hydrophilic polymer, an inorganic metal oxide, a hybrid metal oxide, or a magnetic material;
wherein the hydrophilic polymer includes at least one polymer chosen from poly(N-isopropylacrylamide) (PNIPAM), polyacrylamide (PAM), poly(acrylic acid), polymethacrylate, poly(ethylene glycol), poly(ethylene oxide), poly(-oxazoline) and polyethylenimine (PEI), poly(vinyl alcohol) (PVA), and poly(vinylpyrrolidone) (PVP); the inorganic metal oxide is ZnO or a or a mixed metal oxide; the hybrid metal oxide is a combination of an organic component and ZnO or a or a mixed metal oxide;
wherein the particle has a pore volume of from about 0.001 to about 0.1 cm 3 /g, a surface area of from about 2 to about 100 m 2 /g, or a combination thereof;
wherein the particle includes a diameter of from about 0.3 μm to about 10 μm; and
wherein the etched surface is a roughened surface.

2. The particle of claim 1 , wherein the organic component includes an organosilyl group.

3. The particle of claim 2 , wherein the organosilyl group includes one or more R-Si moieties, where the R group includes a/an hydrocarbyl, alkenyl, alkynyl, aryl, hydroxyl, carboxylic acid, esters, ethers, amide group, or combinations thereof.

4. The particle of claim 1 , wherein the non-porous core is chosen from a hollow core, an inorganic metal oxide core, a hybrid metal oxide core, a polymeric core, or a magnetic core.

5. The particle of claim 4 , wherein the inorganic metal oxide includes an inorganic metal oxide chosen from ZnO, SiO 2 , and M/SiO 2 , wherein M is chosen from Au, Ag, Ni, Fe, Co, FeNi, ZnO, CdS, AgI, CdTe, CdSe, and CaCO 3 .

6. The particle of claim 4 , wherein the magnetic core includes a ferromagnetic substance chosen from Fe 304 , neodymium-based material, or a combination thereof.

7. The particle of claim 4 , wherein the etched surface includes a silane.

8. The particle of claim 7 , wherein the silane is chosen from trialkoxy(octadecyl)silane, a trialkoxy (octyl)silane, or a combination thereof.

9. The particle of claim 7 , wherein the etched surface includes an endcapping agent.

10. The particle of claim 9 , wherein the endcapping agent is a trialkoxy (octyl)silane.

11. The particle of claim 1 , wherein the non-porous core is silica.

12. A particle comprising:
a non-porous core;
a hydrophilic polymer layer comprising an etched surface;
wherein the hydrophilic polymer layer includes at least one polymer chosen from poly(N-isopropylacrylamide) (PNIPAM), polyacrylamide (PAM), poly(acrylic acid), polymethacrylate, poly(ethylene glycol), poly(ethylene oxide), poly(-oxazoline) and polyethylenimine (PEI), poly(vinyl alcohol) (PVA), and poly(vinylpyrrolidone) (PVP);
wherein the particle has a pore volume of from about 0.001 to about 0.1 cm 3 /g, a surface area of from about 2 to about 100 m 2 /g, or a combination thereof;
wherein the particle includes a diameter of from about 0.3 μm to about 10 μm; and
wherein the etched surface is a roughened surface.

Assignees

• Agilent Technologies Inc

Inventors

• Wei Ta-Chen

Classifications

• C01B33/18 Primary

  Preparation of finely divided silica neither in sol nor in gel form; After-treatment thereof (preparation of aerogels by dehydrating gels C01B33/158; treatment to enhance the pigmenting or filling properties C09C) · CPC title

• B01J20/28016

  Particle form · CPC title

• B01J20/28021

  Hollow particles, e.g. hollow spheres, microspheres or cenospheres · CPC title

• C09C1/3045

  Treatment with inorganic compounds · CPC title

• C09C1/3072

  Treatment with macro-molecular organic compounds · CPC title