Cell washing chamber for blood processing centrifuge

Patent metadata

Field	Value
Publication number	US-11964286-B2
Application number	US-202016842205-A
Country	US
Kind code	B2
Filing date	Apr 7, 2020
Priority date	Apr 12, 2019
Publication date	Apr 23, 2024
Grant date	Apr 23, 2024

Abstract

A frustro-conical chamber for separating particles in a fluidized bed for blood component or cell separation. The chamber is characterized by an injection-directing surface for directing inflowing fluid along a frustro-conical wall of the chamber. A dam adjacent the cell-injection port may be circumferentially disposed within the chamber and may have its maximum height adjacent an injection port, and the height may diminish away from the injection port. The injection directing surface may comprise a shelf extending into the interior of the chamber from the injection port, thereby impeding fluid flow in the direction of an outlet port.

First claim

What is claimed is:

1. A chamber for separating particles from a liquid, the chamber comprising:
a first side wall defining a first volume, the first volume being frustro-conical;
a second side wall defining a second volume located above the first volume;
a first port in fluid communication with the first volume, wherein the first port is located at a junction between the first side wall and the second side wall;
an injection-directing surface configured to direct inflowing fluid from the first port along a frustro-conical portion of the first side wall;
a second port in fluid communication with the first volume, wherein the second port is located at an apex of the first volume; and
a third port in fluid communication with the second volume, wherein the third port is located in an upper portion of the second volume, above the second port; and
a dam adjacent the first port, the dam including the injection-directing surface, and the dam configured to prevent flow of particles in liquid into the second volume, the dam at least partially defining a channel for flow of particles away from the second volume, the dam having a maximum height adjacent to the first port, and the dam diminishing in height away from the first port.

2. The chamber of claim 1 , wherein the dam is circumferentially disposed within the chamber and forms a channel between the dam and a portion of the first side wall.

3. The chamber of claim 2 , wherein the height of the dam diminishes away from the first port on at least one side of the first port.

4. The chamber of claim 3 , wherein the height of the dam diminishes away from the first port on both sides of the first port.

5. The chamber of claim 4 , wherein the dam extends partially around a circumference of the chamber.

6. The chamber according to claim 5 , wherein the dam uniformly decreases in height away from the first port.

7. The chamber of claim 4 , wherein the dam extends completely around a circumference of the chamber to a point diametrically across the chamber from the first port, at which point the height of the dam is zero.

8. The chamber according to claim 7 , wherein the dam uniformly decreases in height away from the first port.

9. The A chamber for separating particles from a liquid, the chamber comprising:
a first side wall defining a first volume, the first volume being frustro-conical;
a second side wall defining a second volume located above the first volume;
a first port in fluid communication with the first volume, wherein the first port is located at a junction between the first side wall and the second side wall; an injection-directing surface configured to direct inflowing fluid from the first port along a frustro-conical portion of the first side wall;
a second port in fluid communication with the first volume, wherein the second port is located at an apex of the first volume;
a third port in fluid communication with the second volume, wherein the third port is located in an upper portion of the second volume, above the second port; and
a shelf including the injection-directing surface, the shelf being generally planar and being perpendicular to an axis of the chamber, the axis being defined as a line from the second port to the third port.

10. The chamber according to claim 9 wherein the shelf extends into an interior of the chamber from the first port, thereby impeding fluid flow in a direction of the third port.

11. The chamber according to claim 10 wherein the shelf is coupled to the second side wall of the chamber at a curved edge of the shelf.

12. The chamber according to claim 9 wherein the shelf further comprises an interior edge.

13. The chamber according to claim 12 wherein the interior edge is straight.

14. The chamber according to claim 13 further comprising:
a truncation wall coupled to the interior edge of the shelf and perpendicular to the shelf.

15. The chamber according to claim 14 wherein the truncation wall is planar.

16. The chamber of claim 10 further comprising:
a dam adjacent the first port, the dam configured to prevent flow of particles in liquid into the second volume, wherein the dam at least partially defines a channel for flow of particles away from the second volume wherein the dam has a maximum height adjacent the first port and the dam diminishes in height away from the first port.

17. The chamber according to claim 16 further comprising:
a truncation wall coupled to the shelf and perpendicular to the shelf.

18. The chamber of claim 16 , wherein the height of the dam diminishes away from the first port on both sides of the first port.

19. The chamber of claim 16 , wherein the dam uniformly decreases in height away from the first port.

Assignees

• Terumo Bct Inc

Inventors

• Stanton Briden Ray
• Rykhus Ryan D
• Von Seggern Rachel Michelle
• Marcolina Ashely Ann

Classifications

• B04B7/08 Primary

  Rotary bowls (centrifugal casting machines B22D) · CPC title

• A61M1/36224

  with sensing means or components thereof · CPC title

• A61M1/36225

  with blood pumping means or components thereof · CPC title

• A61M1/362265

  Details of valves · CPC title

• B04B1/02

  without inserted separating walls · CPC title