Pictet-spengler ligation for protein chemical modification
US-2015291699-A1 · Oct 15, 2015 · US
US11964020B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11964020-B2 |
| Application number | US-202217838638-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 13, 2022 |
| Priority date | Dec 4, 2014 |
| Publication date | Apr 23, 2024 |
| Grant date | Apr 23, 2024 |
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A method for removing or controlling or quantifying the presence of aldehydes, in particular acetaldehyde, is described. Such a method is useful in prolonging the shelf life of a pharmaceutical product.
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The invention claimed is: 1. A radioactive pharmaceutical composition comprising an aldehyde scavenger, a radioactive pharmaceutical, and a pharmaceutically acceptable solvent, wherein the aldehyde scavenger is any molecule that has an amino-oxy terminus, and the radioactive pharmaceutical is 2. The composition according to claim 1 , wherein the radioactive pharmaceutical is [ 18 F]flutemetamol. 3. The composition according to claim 1 , wherein the aldehyde scavenger has the following structure: 4. The composition according to claim 1 , wherein the radioactive pharmaceutical is a positron emission tomography (PET) tracer. 5. The composition according to claim 1 , wherein the radioactive pharmaceutical is a 18 F PET tracer. 6. The composition according to claim 1 , wherein the solvent comprises an alcohol. 7. The composition according to claim 6 , wherein said alcohol is ethanol, isopropanol or a bioalcohol. 8. The composition according to claim 6 , wherein said alcohol is ethanol. 9. The composition according to claim 2 , wherein the aldehyde scavenger has the following structure: 10. The composition according to claim 2 , wherein the radioactive pharmaceutical is a positron emission tomography (PET) tracer. 11. The composition according to claim 3 , wherein the radioactive pharmaceutical is a positron emission tomography (PET) tracer. 12. The composition according to claim 3 , wherein the radioactive pharmaceutical is a 18 F PET tracer. 13. A The composition according to claim 3 , wherein the solvent comprises an alcohol. 14. The composition according to claim 13 , wherein said alcohol is ethanol.
Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein (oligopeptides having up to five amino acids {A61K47/183}; polyamino acids A61K47/34) · CPC title
Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent (peptidic linkers A61K47/65) · CPC title
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil · CPC title
having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole · CPC title
the peptide being a RGD-containing peptide · CPC title
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