Device for controlling a piston pump unit for liquid chromatography

Patent metadata

Field	Value
Publication number	US-11959467-B2
Application number	US-202017063870-A
Country	US
Kind code	B2
Filing date	Oct 6, 2020
Priority date	Aug 19, 2011
Publication date	Apr 16, 2024
Grant date	Apr 16, 2024

Abstract

A control device of a piston pump unit comprising at least two piston-cylinder units that operate in a phase-shifted manner for the purpose of liquid chromatography and to a piston pump unit is described. The control device corrects fluctuations of the system pressure while switching from one piston cylinder unit to the respective other piston cylinder unit. The fluctuations can occur as a result of the cooling of the liquid medium that is heated in an adiabatic manner during a pre-compression phase in the working piston. The control unit controls the piston speed of at least one piston-cylinder unit during the transition phase depending on at least one characteristic, which is ascertained from chronologically previously detected pressure values, such that variations of the system pressure as a result of the cooling of the adiabatically heated medium are at least partially compensated for.

First claim

What is claimed is:

1. A method to control a piston pump for liquid chromatography, the piston pump including at least two phase-offset cyclically working piston-cylinder units, which produce a predefined flow of a liquid medium to be delivered at an outlet port, wherein a constant system pressure results at the outlet port, the method comprising:
in a pre-compression phase of one cycle of at least one of the piston-cylinder units, compressing with a piston in the piston-cylinder unit;
measuring a first pressure at a first time and a second pressure at a second time during the pre- compression phase in which an adiabatic heating effect is negligible in the piston-cylinder unit;
extrapolating the first pressure at the first time and the second pressure at the second time to determine a calculated time in which a pressure of the piston-cylinder unit will be at the constant system pressure;
determining a detected time in which the pressure of the piston-cylinder unit is measured with a pressure sensor to be at the constant system pressure;
calculating a time difference based on the calculated time and the detected time; and
calculating a first correction amplitude of the piston speed for at least one piston-cylinder unit based on the time difference,
in which a piston speed is constant during the pre-compression phase,
in which the calculated first correction amplitude of the piston speed is based on a decreasing exponential function, and
applying a first corrected piston speed to at least one piston-cylinder unit during the delivery phase, in which the delivery phase is subsequent to the pre-compression phase, the first corrected piston speed is based on the calculated first correction amplitude of the piston speed.

2. The method of claim 1 further comprising:
opening an outlet valve on the piston-cylinder unit when the pressure of the piston-cylinder unit is at the constant system pressure to begin a delivery phase;
applying a first corrected piston speed to at least one piston-cylinder unit during the delivery phase, in which the delivery phase is subsequent to the pre-compression phase, the first corrected piston speed is based on the calculated first correction amplitude of the piston speed.

3. The method of claim 1 , in which the first pressure ranges from 2 MPa to 10 MPa and the second pressure ranges from 10 MPa to 20 MPa.

4. The method of claim 1 , in which the decreasing exponential function comprises an equation, the equation including:
vk=c ·exp[( t−t 2)/τ]

wherein vk is the first corrected piston speed for at least one of the piston-cylinder units, c is the first correction amplitude of the piston speed, t is a time, t 2 is the detected time, τ is a time constant.

5. The method of claim 1 further comprising
calculating a second correction amplitude of the piston speed based on a characteristic selected from the group consisting of a magnitude of the first correction amplitude, the constant system pressure, and a combination thereof.

6. The method of claim 5 further comprising:
applying a second corrected piston speed to at least one piston-cylinder unit during the delivery phase, the second corrected piston speed is based on the calculated second correction amplitude of the piston speed.

7. The method of claim 6 , in which the calculated second correction amplitude of the piston speed is based on a stepped or rectangular function.

Assignees

• Strobl Christoph
• Dionex Softron Gmbh

Inventors

• Strobl Christoph

Classifications

• F04B11/0058 Primary

  with piston speed control · CPC title

• G01N30/36

  in high pressure liquid systems · CPC title

• G01N2030/324

  speed, flow rate · CPC title

• G01N2030/326

  pumps · CPC title

• G01N30/34

  of fluid composition, e.g. gradient (G01N30/36 takes precedence) · CPC title