Plunger rod and syringe assembly system and method

Patent metadata

Field	Value
Publication number	US-11957883-B2
Application number	US-201816488172-A
Country	US
Kind code	B2
Filing date	Mar 20, 2018
Priority date	Mar 28, 2017
Publication date	Apr 16, 2024
Grant date	Apr 16, 2024

Abstract

A machine for coupling a plunger rod to a syringe assembly may include a carriage including a cradle having a seat portion sized to receive a syringe assembly and an aperture portion disposed above the seat portion and sized to receive a plunger rod. An actuating device may be operatively coupled to the carriage and adapted to move the cradle from a first position to a second position to couple the plunger rod to the syringe assembly. The carriage may be selected from separate and interchangeable first and second carriages, wherein the first carriage includes a cradle adapted to receive a syringe assembly of a first size and the second carriage including a cradle sized to receive a syringe assembly of a second size that is different from the first size.

First claim

What is claimed:

1. A machine for coupling a plunger rod to a syringe assembly, the machine comprising:
a selected carriage including a cradle having a seat portion sized to receive a syringe assembly and an aperture portion disposed above the seat portion and sized to receive the plunger rod;
an actuating device operatively coupled to the selected carriage and adapted to move the cradle from a first position to a second position to couple the plunger rod to the syringe assembly; and
wherein the selected carriage is selected from separate and interchangeable first and second carriages, wherein the first carriage includes a cradle adapted to receive a syringe assembly of a first size and the second carriage including a cradle sized to receive a syringe assembly of a second size that is different from the first size.

2. The machine of claim 1 , further comprising a selected pressure plate positioned above the cradle so that the cradle moves beneath the selected pressure plate when the cradle moves from the first position to the second position, the selected pressure plate adapted to apply a downward force to the plunger rod disposed in the aperture portion of the cradle when the cradle moves from the first position to the second position.

3. The machine of claim 2 , further comprising a selected constant tension spring operatively coupled to the selected pressure plate, the selected pressure plate defining an inlet portion adapted to receive a proximal end of the plunger rod when the cradle moves from the first position to the second position, the selected constant tension spring providing the downward force to the plunger rod, applied via the selected pressure plate, when the cradle moves between the first position and the second position.

4. The machine of claim 1 , wherein the first carriage includes a first pressure plate coupled to the first carriage, and the second carriage includes a second pressure plate coupled to the second carriage, such that the selected pressure plate is coupled to the selected carriage.

5. The machine of claim 1 , further comprising a quick-change fastener and a table, the selected carriage removably coupled to the table by the quick-change fastener.

6. The machine of claim 1 , wherein the first carriage includes a first plunger rod base and the second carriage includes a second plunger rod base, and the actuating device includes a servomotor adapted to be operatively connected to the first and second bases.

7. The machine of claim 1 , further comprising a selected friction element disposed adjacent to the selected carriage, the selected friction element adapted to engage a syringe barrel of the syringe assembly carried by the cradle as the cradle moves from the first position to the second position, the friction element adapted to apply a rotational force to the syringe barrel to spin the syringe assembly relative to the plunger rod when the cradle moves from the first position to the second position.

8. The machine of claim 7 , wherein the first carriage includes a first guide plate coupled to the first carriage and carrying a first friction element and the second carriage includes a second guide plate coupled to the second carriage and carrying a second friction element such that the selected friction element is carried by a selected guide plate coupled to the selected carriage.

9. The machine of claim 1 , further comprising a selected movable plunger rod base coupled to the selected carriage, the selected plunger rod base disposed above the cradle and including an orifice sized to receive a flanged proximal end of the plunger rod, the orifice coaxially aligned with the aperture portion of the cradle, the plunger rod base being movable with the cradle from the first position to the second position;
a selected holding cap having an outwardly extending tab arranged to extend into the orifice of the selected plunger rod base, the selected holding cap removably attached to the selected plunger rod base; and
wherein the selected holding cap is fixed relative to the selected carriage and is disposed in the orifice when the cradle is in the first position.

10. The machine of claim 9 , wherein the selected plunger rod base is selected from separate and interchangeable first and second plunger rod bases, wherein the first plunger rod base includes an orifice adapted to receive a plunger rod of a first size and the second plunger rod base includes an orifice sized to receive a plunger rod of a second size that is different from the first size.

11. The machine of claim 1 , wherein the cradle includes a cradle axis that is coaxial with longitudinal axes of the syringe assembly and the plunger rod when the syringe assembly and the plunger rod are disposed in the cradle, the cradle axis being disposed at an angle greater than zero degrees relative to vertical.

12. The machine of claim 11 , wherein the selected carriage comprises a rotational carousel with a rotational axis that is parallel to the cradle axis such that the rotational axis of the selected carriage is disposed at an angle greater than zero degrees relative to vertical.

13. A machine for coupling a plunger rod to a syringe assembly, the machine comprising:
a carriage having a movable cradle including a seat portion sized to receive a syringe assembly and an aperture portion disposed above the seat portion sized to receive a plunger rod;
an actuating device operatively coupled to the carriage and adapted to move the cradle from a first position to a second position to couple the plunger rod to the syringe assembly;
a pressure plate positioned adjacent to the carriage so that the cradle moves beneath the pressure plate when the cradle moves from the first position to the second position, the pressure plate adapted to apply a downward force to the plunger rod disposed in the aperture portion of the cradle when the cradle moves from the first position to the second position; and
at least one of the following (a) through (e):
(a) a constant tension spring operatively coupled to the pressure plate, the pressure plate defining an inlet portion adapted to receive a proximal end of the plunger rod when the cradle moves from the first position to the second position, the constant tension spring providing the downward force to the plunger rod, applied via the pressure plate, when the cradle moves between the first position and the second position;
(b) a friction element disposed adjacent to the carriage and below the pressure plate, the friction element adapted to engage a syringe barrel of the syringe assembly carried by the cradle as the cradle moves from the first position to the second position, the friction element adapted to apply a rotational force to the syringe barrel to spin the syringe assembly relative to the plunger rod when the cradle moves from the first position to the second position;
(c) wherein the actuating device is operatively connected to the carriage and adapted to index the cradle between the first position and the second position in response to an activation event;
(d) wherein the cradle includes a cradle axis that is coaxial with longitudinal axes of the syringe assembly and plunger rod when the syringe assembly and plunger rod are disposed in the cradle, the cradle axis being disposed at an angle greater than zero degrees relative to vertical; and
(e) wherein the carriage is selected from separate and interchangeable first and second carriages, the first carriage including a cradle having a seat portion sized to receive a syringe assembly of a first size and the second carriage including a cradle having a seat portion sized to receive a syringe assembly of a seco

Assignees

• Amgen Inc

Inventors

• Ketelaars Jeroen
• Leka Lawrence G
• Perez Ernesto J
• Rey Manuel
• Rivera Jomasoel
• Tapia Javier O
• Van Wezel Martin
• Vazquez Francisco Almedina
• Wah Reyes Noel

Classifications

• A61M2209/08

  Supports for equipment · CPC title

• A61M5/31511

  Piston or piston-rod constructions, e.g. connection of piston with piston-rod (A61M5/5066 takes precedence) · CPC title

• A61M5/31515 Primary

  Connection of piston with piston rod · CPC title

• B23P21/00

  Machines for assembling a multiplicity of different parts to compose units, with or without preceding or subsequent working of such parts, e.g. with program control · CPC title

• A61M2207/10

  Device therefor · CPC title