Devices, systems, and methods for assessing a vessel

Patent metadata

Field	Value
Publication number	US-11950884-B2
Application number	US-202117169013-A
Country	US
Kind code	B2
Filing date	Feb 5, 2021
Priority date	Aug 20, 2011
Publication date	Apr 9, 2024
Grant date	Apr 9, 2024

Abstract

Embodiments of the present disclosure are configured to assess the severity of a blockage in a vessel and, in particular, a stenosis in a blood vessel. In some particular embodiments, the devices, systems, and methods of the present disclosure are configured to assess the severity of a stenosis in the coronary arteries without the administration of a hyperemic agent.

First claim

What is claimed is:

1. A system for evaluating a stenosis of a vessel of a patient, the system comprising:
a processing unit configured for communication with a pressure-sensing guide wire and a pressure-sensing instrument, wherein the processing unit is configured to:
receive proximal pressure measurements for a plurality of cardiac cycles of the patient from the pressure-sensing instrument;
receive distal pressure measurements for the plurality of cardiac cycles from the pressure-sensing guide wire, wherein the proximal pressure measurements and the distal pressure measurements are obtained without application of a hyperemic agent to the patient;
perform a pressure ratio calculation based on the proximal pressure measurements and the distal pressure measurements, wherein the pressure ratio calculation results in a plurality of pressure ratios corresponding to the plurality of cardiac cycles;
monitor the pressure ratio calculation to detect an anomaly impacting a cardiac cycle of the plurality of cardiac cycles;
automatically exclude a pressure ratio of the plurality of pressure ratios corresponding to the impacted cardiac cycle; and
output, to a display in communication with the processing unit, a pressure ratio indicator based on the plurality of pressure ratios other than the excluded pressure ratio.

2. The system of claim 1 , wherein the pressure ratio indicator comprises a plot based on the plurality of pressure ratios.

3. The system of claim 1 , wherein the anomaly comprises an interruption in the plurality of cardiac cycles.

4. The system of claim 1 , wherein the anomaly comprises an irregularity in at least one of the proximal pressure measurements or the distal pressure measurements.

5. The system of claim 1 , wherein the pressure ratio calculation results in a respective pressure ratio for each of the plurality of cardiac cycles.

6. The system of claim 5 , wherein the pressure ratio indicator is based on an average of the respective pressure ratios for each of the plurality of cardiac cycles.

7. The system of claim 6 , wherein the processing unit is further configured to calculate a difference between the average for cardiac cycles 1 to n and the average for cardiac cycles 1 to n+1.

8. The system of claim 7 , wherein the processing unit is configured to output the pressure ratio indicator only when the difference is below a threshold value.

9. The system of claim 8 , wherein the threshold value is between about and about 0.05.

10. The system of claim 1 , further comprising the pressure-sensing guide wire.

11. The system of claim 1 , further comprising the pressure-sensing instrument.

12. The system of claim 11 , wherein the pressure-sensing instrument comprises a pressure-sensing catheter.

13. The system of claim 11 , wherein the pressure-sensing instrument comprises a further pressure-sensing guide wire.

Assignees

• Philips Image Guided Therapy Corp
• Medsolve Ltd
• Imperial College Sci Tech & Medicine
• Imperial College Of Science Tech & Medicine

Inventors

• Davies Justin
• Burnett Joseph
• Hattangadi Neil
• Anderson David
• Davies Helen

Classifications

• A61B5/021

  Measuring pressure in heart or blood vessels · CPC title

• A61B5/02

  Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow · CPC title

• A61B5/743

  Displaying an image simultaneously with additional graphical information, e.g. symbols, charts, function plots · CPC title

• A61B5/6851

  Guide wires · CPC title

• A61B2562/0247

  Pressure sensors · CPC title