Robotic platforms to mimic papillary muscle motion ex vivo

Patent metadata

Field	Value
Publication number	US-11945112-B2
Application number	US-202117188663-A
Country	US
Kind code	B2
Filing date	Mar 1, 2021
Priority date	Feb 28, 2020
Publication date	Apr 2, 2024
Grant date	Apr 2, 2024

Abstract

Simulated motion of the papillary muscles in a heart simulator is provided that simulates natural motion of the papillary muscles. This improves heart valve simulation. This can be done with a six degree of freedom robotic actuator (e.g., a Stewart platform or the like) appropriately driven by a controller. This can also be done with a robotic actuator that provides constrained motion of its effector by including a mechanical linkage, as long as the resulting simulated papillary muscle motion includes time-varying position and orientation of the papillary muscle.

First claim

The invention claimed is:

1. A method comprising:
performing heart simulation with a heart simulator configured to provide mounting for at least one heart valve structure;
wherein the heart valve structure includes one or more papillary muscles;
wherein the heart simulator includes one or more robotic actuators having three positional degrees of freedom and at least one rotational degree of freedom for motion;
affixing at least one of the papillary muscles of the heart valve structure to the one or more robotic actuators; and
driving the robotic actuators so as to simulate natural in vivo cardiac motion of the one or more papillary muscles.

2. The method of claim 1 , wherein at least one of the robotic actuators includes:
a base;
an end-effector plate; and
six rods connecting the base to the end-effector plate;
wherein each rod includes a linear actuator such that length changes of the linear actuators control position and orientation of the end-effector plate.

3. The method of claim 1 , wherein at least one of the robotic actuators includes:
a base;
an end-effector plate; and
six rods connecting the base to the end-effector plate;
wherein the base includes six servo motors each connected to a corresponding one of the six rods with a servo arm member such that rotations of the servo motors control position and orientation of the end-effector plate.

4. The method of claim 1 , wherein the heart valve structure is a mitral valve structure.

5. The method of claim 4 , wherein the heart valve structure includes two papillary muscles, and wherein the one or more robotic actuators are two robotic actuators corresponding to the two papillary muscles.

6. The method of claim 1 , wherein the heart valve structure is a natural heart valve structure.

7. The method of claim 1 , wherein the natural in vivo cardiac motion of the one or more papillary muscles is subject-specific cardiac motion obtained by imaging a subject.

8. The method of claim 1 , wherein the natural in vivo cardiac motion of the one or more papillary muscles is a nominal cardiac motion obtained from a database of imaging records.

9. Apparatus comprising:
a heart simulator configured to provide mounting for at least one heart valve structure, wherein the heart valve structure includes one or more papillary muscles;
one or more robotic actuators having three positional degrees of freedom and at least one rotational degree of freedom for motion, wherein at least one of the papillary muscles of the heart valve structure is affixed to the one or more robotic actuators; and
a controller configured to drive the robotic actuators so as to simulate natural in vivo cardiac motion of the one or more papillary muscles.

10. The apparatus of claim 9 , wherein at least one of the robotic actuators includes:
a base;
an end-effector plate; and
six rods connecting the base to the end-effector plate;
wherein each rod includes a linear actuator such that length changes of the linear actuators control position and orientation of the end-effector plate.

11. The apparatus of claim 9 , wherein at least one of the robotic actuators includes:
a base;
an end-effector plate; and
six rods connecting the base to the end-effector plate;
wherein the base includes six servo motors each connected to a corresponding one of the six rods with a servo arm member such that rotations of the servo motors control position and orientation of the end-effector plate.

12. The apparatus of claim 9 , wherein the heart valve structure is a mitral valve structure.

13. The apparatus of claim 12 , wherein the heart valve structure includes two papillary muscles, and wherein the one or more robotic actuators are two robotic actuators corresponding to the two papillary muscles.

14. The apparatus of claim 9 , wherein the heart valve structure is a natural heart valve structure.

15. The apparatus of claim 9 , wherein the natural in vivo cardiac motion of the one or more papillary muscles is subject-specific cardiac motion obtained by imaging a subject.

16. The apparatus of claim 9 , wherein the natural in vivo cardiac motion of the one or more papillary muscles is a nominal cardiac motion obtained from a database of imaging records.

17. Apparatus comprising:
an ex vivo heart simulator configured to provide mounting for at least one heart valve structure, wherein the heart valve structure includes one or more papillary muscles; and
one or more robotic actuators, wherein at least one of the papillary muscles of the heart valve structure is affixed to the one or more robotic actuators;
wherein each of the robotic actuators includes a mechanical linkage relating motion of an end-effector to motion provided by a mechanical input;
a controller configured to drive the one or more mechanical inputs of the one or more robotic actuators to provide simulated motion of the one or more papillary muscles;
wherein the simulated motion simulates natural in vivo cardiac motion of the one or more papillary muscles;
wherein the simulated motion includes time-varying position and orientation of the one or more papillary muscles.

Assignees

• Univ Leland Stanford Junior

Inventors

• Woo Y Joseph
• Paulsen Michael John
• Imbrie-Moore Annabel M
• Park Matthew
• Kulkarni Rohun

Classifications

• B25J9/1075 Primary

  with muscles or tendons · CPC title

• B25J9/123

  Linear actuators · CPC title

• G09B23/30

  Anatomical models {(G09B23/281 - G09B23/288 take precedence)} · CPC title

• B25J9/0057 Primary

  with kinematics chains of the type spherical-prismatic-spherical · CPC title

• B25J9/0051

  with kinematics chains of the type rotary-universal-universal or rotary-spherical-spherical, e.g. Delta type manipulators · CPC title