Particulate coated hydrogel microparticles

Patent metadata

Field	Value
Publication number	US-11944716-B2
Application number	US-202117544544-A
Country	US
Kind code	B2
Filing date	Dec 7, 2021
Priority date	Mar 30, 2018
Publication date	Apr 2, 2024
Grant date	Apr 2, 2024

Abstract

A composition includes a plurality of particulate coated hydrogel microparticles, each of the microparticles including a hydrogel inner core and a particulate shell defined by a plurality of solid nanoparticles, the particulate shell inhibiting aggregation of the microparticles in an aqueous medium and being permeable to allow release of agents from the hydrogel inner core.

First claim

Having described the invention, we claim:

1. A composition comprising:
a plurality of particulate coated hydrogel microparticles, each of the microparticles including a hydrogel inner core and a particulate shell defined by a plurality of solid, inorganic nanoparticles, the hydrogel inner core comprising gelatin and at least one bioactive agent, and the particulate shell inhibiting aggregation of the microparticles in an aqueous medium and being permeable to allow release of bioactive agents provided in the hydrogel inner core from the hydrogel inner core, wherein the microparticles have an average diameter of about 25 μm to about 500 μm, and
a plurality of cells, the cells being dispersed with the microparticles in the composition.

2. The composition of claim 1 , wherein the gelatin is at least partially cross-linked.

3. The composition of claim 1 , wherein the nanoparticles have an average diameter of about 1 nm to about 999 nm.

4. The composition of claim 1 , wherein the solid nanoparticles include silica nanoparticles.

Assignees

• Univ Case Western Reserve

Inventors

• Alsberg Eben
• Tang Rui

Classifications

• A61L27/24 Primary

  Collagen · CPC title

• A61K9/50

  Microcapsules {having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals (A61K9/2081 takes precedence; particles with a single coating comprising drug A61K9/167)} · CPC title

• A61K9/5084

  Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs (tablets containing such a mixture A61K9/2077) · CPC title

• A61K47/02

  Inorganic compounds · CPC title

• A61K47/42

  Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein (oligopeptides having up to five amino acids {A61K47/183}; polyamino acids A61K47/34) · CPC title