Self-retaining sutures of poly-4-hydroxybutyrate and copolymers thereof

Patent metadata

Field	Value
Publication number	US-11944709-B2
Application number	US-202217870619-A
Country	US
Kind code	B2
Filing date	Jul 21, 2022
Priority date	Aug 15, 2014
Publication date	Apr 2, 2024
Grant date	Apr 2, 2024

Abstract

Absorbable monofilament fibers and self-retaining sutures with high tensile strengths have been developed. The straight pull tensile strengths of the absorbable self-retaining sutures closely approximate, equal or exceed the average minimum knot-pull tensile standards set by the United States Pharmacopeia (USP). These higher strength absorbable self-retaining sutures can therefore be used either without needing to oversize the suture for a given procedure, or by oversizing the self-retaining suture by no more than 0.1 mm in diameter. In one embodiment, the absorbable self-retaining sutures are made from poly-4-hydroxybutyrate or copolymers thereof.

First claim

What is claimed is:

1. An absorbable self-retaining suture comprising a monofilament fiber, wherein the monofilament fiber includes a sheath-core structure and at least one tissue retainer, wherein the core is composed of the same polymer as the sheath, wherein the sheath, the core and the at least one tissue retainer each have an indentation hardness, wherein the indentation hardness of the sheath is higher than the indentation hardness of the core, and the indentation hardness of the at least one tissue retainer is less than the indentation hardness of the sheath and higher than the indentation hardness of the core.

2. The absorbable self-retaining suture of claim 1 , wherein the sheath has an indentation hardness of at least 0.07 GPa.

3. The absorbable self-retaining suture of claim 1 , wherein the fiber has been stretched at least 6 times its original length without subsequent relaxation of the fiber.

4. The absorbable self-retaining suture of claim 1 , wherein the at least one tissue retainer is formed in the monofilament fiber.

5. The absorbable self-retaining suture of claim 1 , wherein the polymer is poly-4-hydroxybutyrate or copolymer thereof.

6. The absorbable self-retaining suture of claim 1 , wherein a diameter of the fiber is 0.02 to 1 mm.

7. The absorbable self-retaining suture of claim 1 , wherein a diameter of the fiber is 0.15 to 0.799 mm.

8. The absorbable self-retaining suture of claim 1 , wherein the fiber has a Young's Modulus greater than 860 MPa.

9. The absorbable self-retaining suture of claim 1 , wherein the at least one tissue retainer is composed of the same polymer as the sheath and the core.

Assignees

• Tepha Inc

Inventors

• Rizk Said
• Williams Simon F

Classifications

• A61L17/105 Primary

  Polyesters not covered by A61L17/12 · CPC title

• A61B17/06166

  Sutures (suture materials A61L17/00; manufacture of artificial threads D01D; treatment of threads D06M) · CPC title

• A61L27/18

  obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds · CPC title

• A61L31/06

  obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds {(A61L31/041 takes precedence)} · CPC title

• A61B2017/00004

  (bio)absorbable, (bio)resorbable or resorptive · CPC title