Agent for inducing interferon production containing lactic acid bacteria

Patent metadata

Field	Value
Publication number	US-11944657-B2
Application number	US-202117548904-A
Country	US
Kind code	B2
Filing date	Dec 13, 2021
Priority date	Dec 28, 2010
Publication date	Apr 2, 2024
Grant date	Apr 2, 2024

Abstract

This invention provides an IFN inducer comprising, as an active ingredient, lactic acid bacteria and capable of inducing IFN production, an immunopotentiating agent or prophylactic agent against virus infection comprising such inducer, and a food or drink product comprising such IFN inducer and having IFN-inducing activity, immunopotentiating activity, or prophylactic activity against virus infection. The agent for inducing IFN production comprises, as active ingredients, lactic acid bacteria that can activate plasmacytoid dendritic cells (pDCs) and promote IFN production, such as Lactococcus garvieae NBRC100934, Lactococcus lactis subsp. cremoris JCM16167, Lactococcus lactis subsp. cremoris NBRC100676, Lactococcus lactis subsp. hordniae JCM1180, Lactococcus lactis subsp. hordniae JCM11040, Lactococcus lactis subsp. lactis NBRC12007, Lactococcus lactis subsp. lactis NRIC1150, Lactococcus lactis subsp. lactis JCM5805, Lactococcus lactis subsp. lactis JCM20101, Leuconostoc lactis NBRC12455, Leuconostoc lactis NRIC1540, Pediococcus damnosus JCM5886, or Streptococcus thermophilus TA-45.

First claim

The invention claimed is:

1. A method for preventing cold symptoms, comprising administering to the subject a lactic acid bacteria that is capable of activating plasmacytoid dendritic cells (pDCs) and inducing IFN production, wherein the lactic acid bacteria is Lactococcus lactis subsp. lactis (Lister) Schleifer et al. (1986), deposited with Japan Collection of Microorganisms of Riken BioResource Center, under Accession No. JCM5805.

2. The method according to claim 1 , wherein the lactic acid bacteria is orally administered.

Assignees

• Kirin Holdings Kk

Inventors

• Fujiwara Daisuke
• JONAI Kenta
• Sugimura Tetsu

Classifications

• A61K35/744 Primary

  Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs · CPC title

• A23C9/123

  using only microorganisms of the genus lactobacteriaceae; Yoghurt (A23C9/13 takes precedence) · CPC title

• A23C9/1236

  using Leuconostoc, Pediococcus or Streptococcus sp. other than Streptococcus Thermophilus; Artificial sour buttermilk in general (A23C9/1234, A23C17/02 take precedence; preservation of buttermilk or buttermilk preparations containing, or treated with, microorganisms or enzymes A23B11/55) · CPC title

• A23C19/0323

  using only lactic acid bacteria, e.g. Pediococcus and Leuconostoc species; Bifidobacteria; Microbial starters in general (using moulds A23C19/0682) · CPC title

• A23C19/062

  using only lactic acid bacteria, e.g. pediococcus, leconostoc or bifidus sp., or propionic acid bacteria; Treatment with non-specified acidifying bacterial cultures · CPC title