Delivery devices for forming a distal anchor for mitral valve repair

Patent metadata

Field	Value
Publication number	US-11944540-B2
Application number	US-202017013495-A
Country	US
Kind code	B2
Filing date	Sep 4, 2020
Priority date	Apr 6, 2017
Publication date	Apr 2, 2024
Grant date	Apr 2, 2024

Abstract

Described herein are devices and methods for mitral valve repair. The devices and methods implant a plurality of distal anchors at an annulus of the mitral valve (e.g., the posterior annulus) and tension artificial chordae to pull the portion of the annulus toward an opposite edge and inward into the ventricle. This can effectively reduce the size of the orifice and increase coaptation. The delivery devices can be configured to be actuated to form a distal anchor made of a pre-formed knot. The delivery devices deliver the pre-formed knot in an elongate configuration. Actuation of the delivery device causes the pre-formed knot to transition from the elongate configuration to the deployed configuration by approximating opposite ends of a suture coupled to a coiled configuration to form one or more loops. After formation of the knot, the delivery device can be withdrawn.

First claim

What is claimed is:

1. An apparatus comprising:
a pusher having a distal end;
a needle having a distal portion, the needle slidably disposed within the pusher with the distal portion of the needle extending from the distal end of the pusher; and
a suture having a first section and a second section, each of the first section and the second section having a first portion and a second portion, the second portion of each section including a coil that has a proximal end and a distal end and being formed of multiple turns about an exterior of the needle, a first end of the second portion of the first section being at the distal end of the coil of the first section;
a first end of the second portion of the second section coupled to the first end of the second portion of the first section;
the first section forming a first loop forming segment having a first end at the proximal end of the first coil, a second end at the distal end of the first coil, and being routed proximally external to the second coil and distally internal to the second coil;
the second section forming a second loop forming segment having a first end at the distal end of the second coil, a second end at the proximal end of the first coil, and being routed distally external to the first coil and proximally internal to the first coil;
the second section forming a first loop by routing the first portion of the second section proximally along the exterior of the coil of the second section and distally through the proximal end of the coil of the second section, internal to the coil of the second section, and out a portion of the coil of the second section between the distal end and the proximal end of the coil of the second section;
the first section forming a second loop by routing the first portion of the first section distally along the exterior of the coil of the second section and proximally through the distal end of the coil of the first section, internal to the coil of the first section, and out a portion of the coil of the first section between the distal end and the proximal end of the coil of the first section;
the first portion of the first section being crossed with the first portion of the second section and routed through the first loop; and
the first portion of the second section being crossed with the first portion of the first section and routed through the second loop.

2. The apparatus of claim 1 , wherein the suture is configured for the coil of the first section and the coil of the second section to be formed into a flattened loop by withdrawing the needle proximally through the coil of the first section and the coil of the second section such that the pusher separates the coil of the first section and the coil of the second section from the needle.

3. The apparatus of claim 2 , wherein the apparatus is further configured to form the flattened loop by withdrawing the first portion of the second section relative to the distal end of the pusher to draw the second end of the second loop forming segment proximally from the proximal end of the coil of the first section to deflect the distal end of the coil of the first section laterally with respect to the proximal end of the coil of the first section and to draw the proximal end and the distal end of the coil of the first section towards each other to form a portion of the flattened loop.

4. The apparatus of claim 3 , wherein the apparatus is further configured to form the flattened loop by withdrawing the first portion of the first section relative to the distal end of the pusher to draw the second end of the first loop forming segment proximally from the proximal end of the coil of the second section to deflect the distal end of the coil of the second section laterally with respect to the proximal end of the coil of the second section and to draw the proximal end and the distal end of the coil of the second section towards each other to form a portion of the flattened loop.

5. The apparatus of claim 1 , wherein the needle defines an interior lumen and a distal portion of the needle includes a slot in communication with the lumen.

6. The apparatus of claim 1 further comprising a handle.

7. The apparatus of claim 6 , wherein the needle and the pusher are configured to move relative to the handle.

8. The apparatus of claim 1 further comprising an elongate outer tube forming a lumen, the needle and the pusher movably disposed within the lumen formed by the elongate outer tube.

9. The apparatus of claim 8 further comprising a distal end effector coupled to a distal end portion of the elongate outer tube, the distal end effector configured to distribute a force applied by the elongate outer tube during deployment of a distal anchor formed from the suture.

10. The apparatus of claim 1 , wherein the suture is configured to form a distal anchor comprising a flattened loop.

Assignees

• Univ Maryland
• Harpoon Medical Inc

Inventors

• D'Ambra Michael Nicholas
• Cortez Jr Felino V
• Gammie James S
• Wilson Peter
• Epstein Stephen
• Cournane Stephen
• Etheridge Julie Marie
• Boyd Peter

Classifications

• A61F2/2466 Primary

  Delivery devices therefor · CPC title

• A61F2/2457 Primary

  Chordae tendineae prostheses · CPC title

• A61F2/2463

  Implants forming part of the valve leaflets · CPC title

• A61F2/2487

  Devices within the heart chamber, e.g. splints · CPC title

• A61F2/2412

  with soft flexible valve members, e.g. tissue valves shaped like natural valves · CPC title