Biological sample treatment apparatus

Patent metadata

Field	Value
Publication number	US-11940360-B2
Application number	US-202117340356-A
Country	US
Kind code	B2
Filing date	Jun 7, 2021
Priority date	Nov 16, 2011
Publication date	Mar 26, 2024
Grant date	Mar 26, 2024

Abstract

An apparatus for treating biological samples disposed on substrates, including: an input buffer for receiving one or more substrate holders each being adapted to support a plurality of the substrates; a treatment zone including a plurality of treatment stations each being adapted to receive one of the substrates; a reagent dispenser configured by a controller to dispense reagents to the substrates at the treatment stations; a substrate transport device configured by the controller to transport individual substrates between the substrate holders in the input buffer and the treatment stations.

First claim

The invention claimed is:

1. An apparatus for treating biological samples disposed on substrates, including:
an input buffer for receiving one or more substrate holders each being adapted to support a plurality of the substrates;
a treatment zone including a plurality of treatment stations each being adapted to receive one of the substrates;
a reagent dispenser configured by a controller to dispense reagents to the substrates at the treatment stations;
a substrate transport device configured by the controller to transport individual substrates between the substrate holders in the input buffer and the treatment stations, wherein the controller is configured to cause the substrate transport device to group individual substrates within the treatment zone to treat the biological samples disposed on substrates; and
wherein the controller is configured to cause the substrate transport device to group individual substrates to which a common reagent is to be applied.

2. The apparatus according to claim 1 , wherein the controller is configured to cause the substrate transport device to group individual substrates to which a common protocol is to be applied.

3. The apparatus according to claim 1 , wherein the common reagent is an antibody.

4. The apparatus according to claim 1 , wherein the controller is configured to cause the substrate transport device to group individual substrates which share a common treatment time.

5. The apparatus according to claim 4 , wherein the common treatment time is an epitope retrieval time.

6. The apparatus according to claim 1 , further including an output buffer for receiving one or more of the substrate holders, wherein the substrate transport device is further configured by the controller to transport individual substrates between the treatment stations and the substrate holders in the output buffer.

7. The apparatus according to claim 6 , wherein at least one of the substrate holders received in the input buffer supports substrates from a common patient case, and wherein the controller is further configured to group substrates into at least one of the substrate holders received in the output buffer according to that common patient case.

8. The apparatus according to claim 1 , wherein grouping of substrates is according to any configuration including, but not limited to, common patient case, marker batch, staining batch, specialized protocol, referring doctor, destined pathologist, or other preferred management configuration.

9. The apparatus according to claim 8 , wherein grouping of substrates is configurable by a user according to desired groupings and/or preferences.

10. The apparatus according to claim 1 ,
wherein the substrate transport device is further configured by the controller to transport the individual substrates between the substrate holders in the input buffer and the treatment stations by transporting one of the individual substrates from one of the substrate holders in the input buffer and to the treatment stations without transporting at least one other of the individual substrates from the one of the substrate holders.

11. The apparatus according to claim 10 ,
wherein the substrate transport device is further configured by the controller to transport the individual substrates between the substrate holders in the input buffer and the treatment stations by transporting, after transporting the one of the individual substrates from one of the substrate holders in the input buffer and to the treatment stations without transporting at least one other of the individual substrates from the one of the substrate holders, the at least one other of the individual substrates from the one of the substrate holders to the treatment stations.

Assignees

• Leica Biosystems Melbourne Pty

Inventors

• Dockrill Mark Brian
• Gason Samuel

Classifications

• G01N1/31 Primary

  Apparatus therefor · CPC title

• G01N1/312 Primary

  for samples mounted on planar substrates · CPC title

• G01N35/00029

  provided with flat sample substrates, e.g. slides (G01N35/028 takes precedence) · CPC title

• G01N2035/00079

  Evaporation covers for slides · CPC title

• G01N2035/0094

  optimisation; experiment design · CPC title