Costimulatory b7-h1 in renal cell carcinoma patients: indicator of tumor aggressiveness and potential therapeutic target
US-2020002419-A1 · Jan 2, 2020 · US
Costimulatory B7-H1 in renal cell carcinoma patients: indicator of tumor aggressiveness and potential therapeutic target
US11939378B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11939378-B2 |
| Application number | US-202117402262-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 13, 2021 |
| Priority date | Oct 6, 2004 |
| Publication date | Mar 26, 2024 |
| Grant date | Mar 26, 2024 |
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- Title
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Abstract
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The invention features methods of diagnosis by assessing B7-H1 expression in a tissue from a subject that has, or is suspected of having, cancer, methods of treatment with agents that interfere with B7-H1-receptor interaction, methods of selecting candidate subjects likely to benefit from cancer immunotherapy, and methods of inhibiting expression of B7-H1.
First claim
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What is claimed is: 1. A method for treating renal cell carcinoma in a human comprising administering, to said human, an anti-PD-1 antibody that interferes with an interaction between B7-H1 and PD-1, wherein some or all cells of said renal cell carcinoma express B7-H1. 2. The method of claim 1 , wherein said anti-PD-1 antibody is an IgG antibody. 3. The method of claim 1 , wherein ≥10 percent of said cells of said renal cell carcinoma express B7-H1.
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of other specific parts of the body, e.g. brain · CPC title
of the liver or pancreas · CPC title
involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites · CPC title
- C07K16/2803Primary
against the immunoglobulin superfamily · CPC title
IL-2 · CPC title
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- What does patent US11939378B2 cover?
- The invention features methods of diagnosis by assessing B7-H1 expression in a tissue from a subject that has, or is suspected of having, cancer, methods of treatment with agents that interfere with B7-H1-receptor interaction, methods of selecting candidate subjects likely to benefit from cancer immunotherapy, and methods of inhibiting expression of B7-H1.
- Who is the assignee on this patent?
- Mayo Found Medical Education & Res
- What technology area does this patent fall under?
- Primary CPC classification C07K16/2803. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Mar 26 2024 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).