Red fluorescent aldehyde dehydrogenase (aldh) substrate
US-2015369738-A1 · Dec 24, 2015 · US
Physiologically stable fluorophore and performing fluorescence probing
US11939345B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11939345-B2 |
| Application number | US-202017117424-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 10, 2020 |
| Priority date | Dec 17, 2019 |
| Publication date | Mar 26, 2024 |
| Grant date | Mar 26, 2024 |
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- Title
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Abstract
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A physiologically stable fluorophore includes a terminal moiety including a terminal reactive site that reacts with a reactive group of a substrate; a stability linker covalently bonded to the terminal moiety; and a bridge moiety covalently bonded to the stability linker such that the stability linker is interposed through chemical bonds between the bridge moiety and the terminal moiety; and a fluorescent moiety covalently bonded to the bridge moiety of the redox moiety and including: an electron bandgap mediator that is covalently bonded to the bridge moiety; a coordinate center covalently bonded to the electron bandgap mediator and that forms a Zwitterionic member with an atom in the electron bandgap mediator; and a steric hinder bonded to the electron bandgap mediator to provide steric hindrance for protection of the coordinate center.
First claim
Opening claim text (preview).
What is claimed is: 1. A physiologically stable fluorophore for performing fluorescence probing, the physiologically stable fluorophore comprises wherein the physiologically stable fluorophore is stable from pH=1 to pH=10 such that the photophysics of the physiologically stable fluorophore is conserved from pH=2 to pH=10. 2. A process for performing fluorescence probing with a physiologically stable fluorophore the process comprising: contacting a surface extracted cellulose nanofiber substrate with the physiologically stable fluorophore; forming a fluorophore-substrate complex from the physiologically stable fluorophore and the substrate in response to contacting the substrate with the physiologically stable fluorophore; subjecting the fluorophore-substrate complex to probe radiation; electronically exciting the physiologically stable fluorophore in the fluorophore-substrate complex in response to subjecting the fluorophore-substrate complex to the probe radiation; producing fluorescence from the physiologically stable fluorophore in the fluorophore-substrate complex in response to electronically exciting the physiologically stable fluorophore in the fluorophore-substrate complex; and determining, from the fluorescence from the physiologically stable fluorophore, the redox state of the substrate to perform single-electron transfer fluorescence probing; wherein the physiologically stable fluorophore is stable from pH=1 to pH=10 such that the photophysics of the physiologically stable fluorophore is conserved from pH=2 to pH=10.
Assignees
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Classifications
- C07F5/022Primary
without C-boron linkages · CPC title
the fluorescent group being a small organic molecule · CPC title
Aryl or aralkyl ethers · CPC title
Aryl ethers; Aralkyl ethers · CPC title
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- What does patent US11939345B2 cover?
- A physiologically stable fluorophore includes a terminal moiety including a terminal reactive site that reacts with a reactive group of a substrate; a stability linker covalently bonded to the terminal moiety; and a bridge moiety covalently bonded to the stability linker such that the stability linker is interposed through chemical bonds between the bridge moiety and the terminal moiety; and a …
- Who is the assignee on this patent?
- Government Of The Us Secretary Of Commerce
- What technology area does this patent fall under?
- Primary CPC classification C07F5/022. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Mar 26 2024 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).