Biphenyl derivative compound and use thereof

Patent metadata

Field	Value
Publication number	US-11939308-B2
Application number	US-201917059754-A
Country	US
Kind code	B2
Filing date	May 30, 2019
Priority date	May 30, 2018
Publication date	Mar 26, 2024
Grant date	Mar 26, 2024

Abstract

The present disclosure provides a novel biphenyl derivative compound or a pharmaceutically acceptable salt thereof. The biphenyl derivative compound or pharmaceutically acceptable salt thereof according to the present disclosure is a compound that increases Nm23-H1/NDPK activity and can inhibit cancer metastasis and growth. Thus, it exhibits excellent effects not only on the prevention, alleviation and treatment of cancer, but also on the suppression of cancer metastasis.

First claim

The invention claimed is:

1. A biphenyl derivative compound of the following Formula 1 or a pharmaceutically acceptable salt thereof:

wherein
L is —(CH 2 —CH 2 )—, and
each of R 1 , R 2 , R 3 and R 4 is independently hydroxy or methoxy.

2. The biphenyl derivative compound or pharmaceutically acceptable salt thereof according to claim 1 , wherein at least two of R 1 , R 2 , R 3 and R 4 are methoxy groups.

3. The biphenyl derivative compound or pharmaceutically acceptable salt thereof according to claim 1 , wherein the compound of Formula 1 is selected from among the following compounds:

4. A pharmaceutical composition for treating or preventing cancer, the pharmaceutical composition containing, as an active ingredient, the biphenyl derivative compound or pharmaceutically acceptable salt thereof according to claim 1 .

5. The pharmaceutical composition of claim 4 , wherein the cancer is cancer selected from the group consisting of breast cancer, lung cancer, melanoma, prostate cancer, colorectal cancer, bladder cancer, bone cancer, blood cancer, thyroid cancer, parathyroid cancer, bone marrow cancer, rectal cancer, throat cancer, laryngeal cancer, esophageal cancer, pancreatic cancer, stomach cancer, tongue cancer, skin cancer, brain tumor, uterine cancer, head or neck cancer, gallbladder cancer, oral cancer, colon cancer, anal cancer, central nervous system tumor, liver cancer, colorectal cancer, and combinations thereof.

6. The pharmaceutical composition of claim 4 , wherein the cancer is cancer selected from the group consisting of breast cancer, lung cancer, colorectal cancer, and skin cancer.

7. A method for treating or preventing cancer, the method comprising a step of administering the pharmaceutical composition according to claim 4 to a subject that is at risk of developing cancer or has developed cancer.

8. A composition for suppressing cancer metastasis, the composition containing, as an active ingredient, the biphenyl derivative compound or pharmaceutically acceptable salt thereof according to claim 1 .

9. A method for suppressing cancer metastasis, the method comprising a step of administering the composition according to claim 8 to a subject that is at risk of cancer metastasis or has metastasized cancer.

10. A food composition for preventing or alleviating cancer, the food composition containing, as an active ingredient, the biphenyl derivative compound or pharmaceutically acceptable salt thereof according to claim 1 .

11. The method according to claim 7 , wherein the cancer is cancer selected from the group consisting of breast cancer, lung cancer, melanoma, prostate cancer, colorectal cancer, bladder cancer, bone cancer, blood cancer, thyroid cancer, parathyroid cancer, bone marrow cancer, rectal cancer, throat cancer, laryngeal cancer, esophageal cancer, pancreatic cancer, stomach cancer, tongue cancer, skin cancer, brain tumor, uterine cancer, head or neck cancer, gallbladder cancer, oral cancer, colon cancer, anal cancer, central nervous system tumor, liver cancer, colorectal cancer, and combinations thereof.

12. The method according to claim 7 , wherein the cancer is cancer selected from the group consisting of breast cancer, lung cancer, colorectal cancer, and skin cancer.

13. A method for treating or preventing cancer, the method comprising a step of administering a pharmaceutical composition containing, as an active ingredient, the biphenyl derivative compound or pharmaceutically acceptable salt thereof according to claim 3 to a subject that is at risk of developing cancer or has developed cancer.

Assignees

• Ewha University—Industry Collaboration Found

Inventors

• Lee Kong Joo
• Lee Hee-Yoon
• Lee Je Jin
• Kim Hwang Suk
• Seo Ji-Wan
• Lee Hongsoo
• Shin Ji Soo
• Kim Bo-Kyung

Classifications

• C07D303/18 Primary

  by etherified hydroxyl radicals · CPC title

• A23L33/10

  using additives (addition of substantially indigestible substances A23L33/21) · CPC title

• A61P35/04

  specific for metastasis · CPC title

• C07C35/21

  polycyclic, at least one hydroxy group bound to a non-condensed ring · CPC title

• C07C43/23

  containing hydroxy or O-metal groups · CPC title