Bioprinted tissue with therapy capability

Patent metadata

Field	Value
Publication number	US-11938015-B2
Application number	US-202016879973-A
Country	US
Kind code	B2
Filing date	May 21, 2020
Priority date	May 21, 2020
Publication date	Mar 26, 2024
Grant date	Mar 26, 2024

Abstract

A set of sensor data collected from one or more sensors associated with a bioprinted tissue is received. The set of sensor data is analyzed to determine whether a condition for controlled movement of the bioprinted tissue is met. A control signal is issued to a set of expansive elements to perform the controlled movement in response to determining that the condition for controlled movement of the bioprinted tissue is met.

First claim

What is claimed is:

1. A method comprising:
receiving a set of sensor data collected from one or more sensors associated with a bioprinted tissue, wherein the set of sensor data includes chemical concentration data collected by at least one chemical sensor;
analyzing the set of sensor data to determine whether a condition for controlled movement of the bioprinted tissue is met; and
issuing, in response to determining that the condition for controlled movement of the bioprinted tissue is met, a control signal to a set of expansive elements to perform the controlled movement.

2. The method of claim 1 , wherein the controlled movement is a peristalsis movement.

3. The method of claim 1 , wherein the set of sensor data includes force data collected by at least one piezoelectric sensor.

4. The method of claim 3 , wherein determining that the condition for controlled movement is met includes determining that a force sensor value exceeds a force threshold.

5. The method of claim 1 , wherein determining that the condition for controlled movement is met includes determining that a concentration of a first chemical species exceeds a concentration threshold.

6. The method of claim 1 , wherein issuing the control signal to the set of expansive elements includes issuing a first control signal to a first expansive element to expand by a first amount, issuing a second control signal to a second expansive element to expand by a second amount, and issuing a third control signal to a third expansive element to expand by a third amount.

7. A system comprising:
a bioprinted tissue, the bioprinted tissue including a plurality of sensors and a plurality of expansive elements;
one or more memories; and
one or more processors communicatively coupled to the one or more memories and the bioprinted tissue configured to perform a method, the method comprising:
receiving a set of sensor data from the one or more sensors of the bioprinted tissue, wherein the set of sensor data includes liquid density data collected by at least one liquid density sensor;
analyzing the set of sensor data to determine whether a condition for controlled movement of the bioprinted tissue is met; and
issuing, in response to determining that the condition for controlled movement of the bioprinted tissue is met, a control signal to a set of expansive elements to perform the controlled movement.

8. The system of claim 7 , wherein the controlled movement is a mixing movement.

9. The system of claim 7 , wherein determining that the condition for controlled movement is met includes determining that a liquid density value exceeds a liquid density threshold.

10. The system of claim 7 , wherein the set of sensor data includes chemical concentration data collected by at least one chemical sensor.

11. The system of claim 10 , wherein determining that the condition for controlled movement is met includes determining that a concentration of a first chemical species exceeds a concentration threshold.

12. The system of claim 7 , wherein issuing the control signal to the set of expansive elements includes issuing a first control signal to a first expansive element to expand by a first amount, issuing a second control signal to a second expansive element to expand by a second amount, and issuing a third control signal to a third expansive element to expand by a third amount.

13. A computer program product comprising one or more computer readable storage media, and program instructions collectively stored on the one or more computer readable storage media, the program instructions comprising instructions configured to cause one or more processors to perform a method comprising:
receiving a set of sensor data collected from one or more sensors associated with a bioprinted tissue;
analyzing the set of sensor data to determine whether a condition for controlled movement of the bioprinted tissue is met; and
issuing, in response to determining that the condition for controlled movement of the bioprinted tissue is met, a control signal to a set of expansive elements to perform the controlled movement, wherein the set of expansive elements includes a magnetically actuated spring device.

14. The computer program product of claim 13 , wherein the set of sensor data includes temperature data collected by at least one thermal sensor.

15. The computer program product of claim 14 , wherein determining that the condition for controlled movement is met includes determining that a temperature value exceeds a temperature threshold.

16. The computer program product of claim 15 , wherein determining that the condition for controlled movement is met includes ascertaining a presence of a first chemical species.

17. The computer program product of claim 13 , wherein the set of sensor data includes chemical concentration data collected by at least one chemical sensor.

18. The computer program product of claim 13 , wherein issuing the control signal to the set of expansive elements includes issuing a first control signal to a first expansive element to expand by a first amount, issuing a second control signal to a second expansive element to expand by a second amount, and issuing a third control signal to a third expansive element to expand by a third amount.

Assignees

• IBM

Inventors

• Rakshit Sarbajit K

Classifications

• A61F2/04 Primary

  Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts (A61F2/18, A61F2/20 take precedence; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95) · CPC title

• G01L1/16

  using properties of piezoelectric devices · CPC title

• G01L1/18

  using properties of piezo-resistive materials, i.e. materials of which the ohmic resistance varies according to changes in magnitude or direction of force applied to the material · CPC title

• G01L5/101

  using sensors inserted into the flexible member · CPC title

• G01L5/162

  of piezoresistors · CPC title