Flow path plate, analysis apparatus, and analysis method

Patent metadata

Field	Value
Publication number	US-11933716-B2
Application number	US-202117236265-A
Country	US
Kind code	B2
Filing date	Apr 21, 2021
Priority date	Oct 30, 2018
Publication date	Mar 19, 2024
Grant date	Mar 19, 2024

Abstract

A flow path plate for analysis of a component in a liquid sample, flowing within the flow path plate, by irradiating the liquid sample with measurement light is provided. The flow path plate includes a plate body having transparency; a flow path formed within the plate body and through which the liquid sample passes; a chamber provided in a part of the flow path and formed by a space having a cross-sectional area greater than cross-sectional areas of other parts of the flow path; and an internal part for detection disposed in the chamber and having a through hole. The through hole has an inner wall surface and constitutes a part of the flow path. The measurement light passes through the through hole. The internal part is configured to inhibit transmission of the measurement light from the inner wall surface of the through hole to the outside.

First claim

What is claimed is:

1. A flow path plate for analysis of a component in a liquid sample, flowing within the flow path plate, by irradiating the liquid sample with measurement light, the flow path plate comprising:
a plate body having a plate shape and having transparency;
a flow path formed within the plate body and through which the liquid sample passes;
a chamber provided in a first part of the flow path and formed by a space having a cross-sectional area greater than cross-sectional areas of other parts of the flow path; and
an internal part for detection disposed in the chamber and having a through hole, the through hole having an inner wall surface and constituting a part of the flow path,
wherein the measurement light passes through the through hole, and
wherein the internal part is configured to inhibit transmission of the measurement light from the inner wall surface of the through hole to outside.

2. The flow path plate according to claim 1 , wherein the internal part includes one or both of an inflow path and an outflow path, the inflow path being connected to one end of the through hole, and the outflow path being connected to another end of the through hole.

3. The flow path plate according to claim 1 , wherein the internal part includes one or both of an engineering plastic and a super engineering plastic.

4. The flow path plate according to claim 1 , further comprising an antireflection part disposed on the inner wall surface of the through hole and configured to reduce reflection of the measurement light.

5. The flow path plate according to claim 4 , wherein the antireflection part includes one or both of an antireflection film and a microstructure, the microstructure having a plurality of protrusions or a plurality of recesses.

6. The flow path plate according to claim 1 , wherein the plate body includes at least two plates, each having a plate shape, one being a first plate and another being a second plate,
wherein one or both of the first plate and the second plate have grooves, and
wherein the first plate and the second plate are bonded together such that the flow path is formed by the grooves.

7. The flow path plate according to claim 6 , wherein the internal part is disposed in the chamber such that an axial direction of the through hole is parallel to or perpendicular to one main surface of the plate body.

8. The flow path plate according to claim 6 , wherein each of the first plate and the second has grooves, and the chamber is formed by a first groove of the grooves of the first plate and by a second groove of the grooves of the second plate, and
wherein the internal part has a polygonal cross-sectional shape or a circular cross-sectional shape as viewed in an axial direction of the through hole.

9. The flow path plate according to claim 8 , wherein the internal part has the polygonal cross-sectional shape as viewed in the axial direction of the through hole,
wherein a cross-sectional shape of the first groove and a cross-sectional shape of the second groove are asymmetrical, and
wherein the through hole of the internal part disposed in the chamber is located in either the first groove or the second groove.

10. The flow path plate according to claim 6 , wherein the internal part includes one or both of a first connection flow path and a second connection flow path, the first connection flow path connecting one end of the through hole to the flow path formed within the plate body, and the second connection flow path connecting another end of the through hole to the flow path formed within the plate body.

11. The flow path plate according to claim 1 , further comprising a separation element chamber in a second part on an upstream side of the flow path relative to the first part of the flow path through which the measurement light passes, and
wherein a separation element is disposed in the separation element chamber.

12. An analysis apparatus comprising:
the flow path plate according to claim 1 ;
a light emitter configured to emit the measurement light to the internal part in the flow path plate such that the measurement light passes through the through hole; and
a light receiver configured to receive the measurement light that has passed through the through hole in the flow path plate.

13. An analysis method for analysis of a component in a liquid sample by using a flow path plate that includes
a plate body having a plate shape and having transparency,
a flow path formed within the plate body and through which the liquid sample passes,
a chamber provided in a part of the flow path and formed by a space having a cross-sectional area greater than cross-sectional areas of other parts of the flow path, and
an internal part for detection disposed in the chamber and having a through hole, the through hole having an inner wall surface and through which the liquid sample and measurement light pass,
wherein the internal part is configured to inhibit transmission of the measurement light from the inner wall surface of the through hole to outside, the method comprising:
emitting the measurement light into the through hole of the internal part; and
analyzing the measurement light that has passed through the liquid sample flowing through the through hole of the internal part.

Assignees

• Alps Alpine Co Ltd

Inventors

• Ito Junko

Classifications

• G01N21/05 Primary

  Flow-through cuvettes (G01N21/09 takes precedence; handling fluid samples G01N1/10) · CPC title

• G01N21/33

  using ultraviolet light (G01N21/39 takes precedence) · CPC title

• G01N21/85

  Investigating moving fluids or granular solids · CPC title

• G01N30/74 Primary

  Optical detectors {(measurement of intensity, velocity, spectral content, polarisation, or phase of infrared, visible or ultraviolet light G01J)} · CPC title

• G01N2030/027

  Liquid chromatography · CPC title