Method for manufacturing a polymer-based fibrous scaffold

Patent metadata

Field	Value
Publication number	US-11932973-B2
Application number	US-202117511641-A
Country	US
Kind code	B2
Filing date	Oct 27, 2021
Priority date	Nov 3, 2020
Publication date	Mar 19, 2024
Grant date	Mar 19, 2024

Abstract

A method for manufacturing a polymer-based fibrous scaffold is disclosed. The method includes the following step: providing an electrospinning device comprising a collector; and injecting a polymer solution into the electrospinning device to produce a single jet fiber, wherein the single jet fiber is piled on the collector to form a fibrous scaffold.

First claim

What is claimed is:

1. A method for manufacturing a polymer-based fibrous scaffold, comprising the following steps:
providing an electro spinning device comprising a collector; and
injecting a polymer solution into the electrospinning device to produce a single jet fiber, wherein the single jet fiber is piled to form the polymer-based fibrous scaffold on the collector,
wherein a fiber packing density of the polymer-based fibrous scaffold is gradually reduced from a base layer of the polymer-based fibrous scaffold to a top layer of the polymer-based fibrous scaffold.

2. The method of claim 1 , wherein the single jet fiber is piled on the collector by auto-switching between two modes of a whipping motion and a cantilever-like single jet, respectively.

3. The method of claim 2 , wherein the single jet fiber is piled at a first direction by the whipping motion, and the first direction is perpendicular to a surface of the collector.

4. The method of claim 3 , wherein the single jet fiber is piled at a second direction and a third direction by the cantilever-like single jet, and the second direction and the third direction are respectively perpendicular to the first direction.

5. The method of claim 1 , wherein the single jet fiber is piled in a spiral shape.

6. The method of claim 1 , wherein the single jet fiber is piled on the collector in multiple layers.

7. The method of claim 1 , wherein the polymer-based fibrous scaffold is a three-dimensional fibrous scaffold.

8. The method of claim 1 , wherein a surface of a fiber of the polymer-based fibrous scaffold comprises a plurality of pores.

9. The method of claim 1 , wherein the polymer solution comprises at least one organic solvent.

10. The method of claim 1 , wherein the collector is a three-dimensional collector.

11. The method of claim 1 , wherein an average diameter of a fiber of the polymer-based fibrous scaffold is in a range from 1 μm to 100 μm.

12. The method of claim 1 , wherein a size of a pore of a fiber of the polymer-based fibrous scaffold is in a range from 3 μn to 100 μm.

13. The method of claim 1 , wherein a fiber of the polymer-based fibrous scaffold comprises a plurality of fiber segments and a capsule morphology segment, the capsule morphology segment is located between two of the adjacent plurality of fiber segments, and a diameter of the capsule morphology segment is greater than that of the two of the adjacent plurality of fiber segments.

Assignees

• Academia Sinica

Inventors

• Chou Chia-Fu
• Navaneethan Balchandar

Classifications

• D03D27/00 Primary

  Woven pile fabrics · CPC title

• D01D5/003

  the material being a polymer solution or dispersion (D01D5/0053 takes precedence) · CPC title

• D10B2331/041

  derived from hydroxy-carboxylic acids, e.g. lactones · CPC title

• D01D5/0076 Primary

  characterised by the collecting device, e.g. drum, wheel, endless belt, plate or grid (D01D5/0046 takes precedence) · CPC title

• D01D5/0092 Primary

  characterised by the electrical field, e.g. combined with a magnetic fields, using biased or alternating fields · CPC title