Methods for producing abienol
US-2017362583-A1 · Dec 21, 2017 · US
Method for producing albicanol and/or drimenol
US11932894B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11932894-B2 |
| Application number | US-202217673465-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 16, 2022 |
| Priority date | Jun 2, 2017 |
| Publication date | Mar 19, 2024 |
| Grant date | Mar 19, 2024 |
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- Title
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Abstract
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Described herein is a method of producing a drimane sesquiterpene such as albicanol, drimenol and/or derivatives thereof by contacting at least one polypeptide with farnesyl diphosphate (FPP) with a polypeptide including a Haloacid dehalogenase (HAD)-like hydrolase domain and having bifunctional terpene synthase activity. The method may be performed in vitro or in vivo. Also described herein are amino acid sequences of polypeptides useful in the methods and nucleic acids encoding the polypeptides described. The described method further provides host cells or organisms genetically modified to express the polypeptides and useful to produce a drimane sesquiterpene such as albicanol, drimenol and/or derivatives thereof.
First claim
Opening claim text (preview).
The invention claimed is: 1. An isolated polypeptide comprising a Haloacid dehalogenase (HAD)-like hydrolase domain and having bifunctional terpene synthase activity comprising a) an amino acid sequence having at least 90%, 95%, 96%, 97%, 98% or 99% sequence identity to SEQ ID NO: 1 or SEQ ID NO: 5, wherein the amino acid sequence is a variant of SEQ ID NO: 1 or SEQ ID NO: 5 and does not have 100% sequence identity to SEQ ID NO: 1 or SEQ ID NO: 5; b) a sequence as set forth in SEQ ID NO: 53, SEQ ID NO: 54, or SEQ ID NO: 55; and c) a sequence as set forth in SEQ ID NO: 56, SEQ ID NO: 57, or SEQ ID NO: 58. 2. The isolated polypeptide of claim 1 , wherein the polypeptide further comprises one or more conserved motif as set forth in SEQ ID NO: 59, SEQ ID NO: 60, SEQ ID NO: 61, and SEQ ID NO: 62.
Assignees
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Classifications
- C12P7/02Primary
containing a hydroxy group · CPC title
Lyases (4.) · CPC title
acting on phosphates (4.2.3) · CPC title
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- What does patent US11932894B2 cover?
- Described herein is a method of producing a drimane sesquiterpene such as albicanol, drimenol and/or derivatives thereof by contacting at least one polypeptide with farnesyl diphosphate (FPP) with a polypeptide including a Haloacid dehalogenase (HAD)-like hydrolase domain and having bifunctional terpene synthase activity. The method may be performed in vitro or in vivo. Also described herein ar…
- Who is the assignee on this patent?
- Firmenich & Cie
- What technology area does this patent fall under?
- Primary CPC classification C12P7/02. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Mar 19 2024 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).