Preparing an extracorporeal blood treatment apparatus

Patent metadata

Field	Value
Publication number	US-11931493-B2
Application number	US-201917293228-A
Country	US
Kind code	B2
Filing date	Nov 18, 2019
Priority date	Nov 27, 2018
Publication date	Mar 19, 2024
Grant date	Mar 19, 2024

Abstract

A control system is configured to implement a method of preparing a blood treatment apparatus ( 1 ) for blood treatment. The method comprises installing, by use of a disposable arrangement, first and second flow circuits (C 1 , C 2 ) separated by a semi-permeable membrane ( 25 ), the first flow circuit (C 1 ) being connected for fluid communication with the apparatus ( 1 ) and the second flow circuit (C 2 ) being connected to form a closed loop that includes a sterilizing filter ( 46 ) and, optionally, a container ( 30 ). The method further comprises performing backfiltration to transfer a human-compatible fluid from the first flow circuit (C 1 ) to the second flow circuit (C 2 ) through the semi-permeable membrane ( 25 ), and circulating ( 304 ) the human-compatible fluid in the closed loop of second flow circuit (C 2 ), to thereby sterilize the human-compatible fluid by the sterilizing filter ( 46 ) and, optionally, collect a resulting sterile fluid in the container ( 30 ) for later use.

First claim

The invention claimed is:

1. A control system for a blood treatment apparatus, said control system comprising:
a memory; and
a processor in operable communication with the memory, the processor configured to:
instruct an operator to install a first flow circuit for conducting a fluid provided by the blood treatment apparatus through a dialyzer;
instruct the operator to install a second flow circuit that is separated from the first flow circuit by a semi-permeable membrane of the dialyzer, the second flow circuit comprising connectors for connection to a vascular system of a subject during blood treatment, wherein the second flow circuit is configured to be disconnected from the vascular system and form a closed loop that includes a sterilizing filter;
operate the blood treatment apparatus to pump a human-compatible fluid into the first flow circuit so that a portion of the human-compatible fluid flows through the semi-permeable membrane into the second flow circuit; and
operate the blood treatment apparatus to circulate said portion of the human-compatible fluid in the closed loop of the second flow circuit, to thereby sterilize said portion of the human-compatible fluid by the sterilizing filter.

2. The control system of claim 1 , wherein the second flow circuit is installed to further include a container, said processor being further configured to operate the blood treatment apparatus to collect a sterile fluid in the container, the sterile fluid being generated by circulating said portion of the human-compatible fluid in the closed loop.

3. The control system of claim 2 , wherein said portion of the human-compatible fluid is circulated through the container.

4. The control system of claim 2 , wherein the processor is configured to instruct the operator to form the closed loop by directly or indirectly connecting the connectors to an inlet port and an outlet port, respectively, on the container.

5. The control system of claim 4 , wherein the second flow circuit is installed with the sterilizing filter being co-located with the outlet port so that said portion of the human-compatible fluid flows through the sterilizing filter when leaving the container via the outlet port.

6. The control system of claim 4 , wherein the second flow circuit is installed with the sterilizing filter directly or indirectly connected to one of the inlet and outlet ports of the container.

7. The control system of claim 2 , wherein the second flow circuit is installed with the sterilizing filter located within the container.

8. The control system of claim 4 , wherein the inlet and outlet ports define an inlet opening and an outlet opening, respectively, inside the container, and wherein the processor is configured to instruct the operator to install the second flow circuit such that the container locates the inlet opening above the outlet opening.

9. The control system of claim 2 , wherein the processor is further configured to:
instruct the operator to connect the connectors to the vascular system of the subject, operate the blood treatment apparatus to perform said blood treatment,
instruct the operator, subsequent to said blood treatment, to establish fluid communication between the container holding the sterile fluid and the second flow circuit, and operate the blood treatment apparatus to drive blood in the second flow circuit back into the vascular system of the subject while drawing at least a portion of the sterile fluid in the container into the second flow circuit.

10. The control system of claim 2 , wherein the processor is further configured to:
instruct the operator to connect the connectors to the vascular system of the subject and install the container holding the sterile fluid for fluid communication with the second flow circuit, and
operate the blood treatment apparatus to perform said blood treatment, and to introduce a portion of the sterile fluid in the container into the second flow circuit during said blood treatment.

11. The control system of claim 1 , wherein the processor is further configured to ventilate the second flow circuit to expel gaseous substances.

12. The control system of claim 1 , wherein the processor is configured to circulate said portion of the human-compatible fluid in the closed loop of the second flow circuit so that said portion of the human-compatible fluid is passed at least once through the sterilizing filter.

13. The control system of claim 1 , wherein the processor is further configured to, while the human-compatible fluid is pumped into the first flow circuit, cause a flow restriction in the first flow circuit downstream from the dialyzer.

14. The control system of claim 1 , wherein the processor is configured to circulate said portion of the human-compatible fluid in the closed loop of the second flow circuit for a predefined time period after completion of said pumping the portion of the human-compatible fluid through the semi-permeable membrane into the second flow circuit.

15. The control system of claim 1 , wherein the human-compatible fluid comprises one of a saline solution, a treatment fluid for use during said blood treatment, and water.

16. A blood treatment apparatus comprising a fluid supply unit configured to supply a human-compatible fluid to a first flow circuit when the first flow circuit is connected to the blood treatment apparatus, a pump operable to engage with a second flow circuit when the second flow circuit is connected to the blood treatment apparatus, and the control system of claim 1 .

17. A method of preparing a blood treatment apparatus for blood treatment, said method comprising:
installing a first flow circuit for conducting a fluid provided by the blood treatment apparatus through a dialyzer,
installing a second flow circuit that is separated from the first flow circuit by a semi-permeable membrane of the dialyzer, the second flow circuit comprising connectors for connection to a vascular system of a subject during a blood treatment, wherein the second flow circuit is configured to be disconnected from the vascular system and form a closed loop that includes a sterilizing filter,
pumping, before the blood treatment and by the blood treatment apparatus, a human-compatible fluid into the first flow circuit so that a portion of the human-compatible fluid flows through the semi-permeable membrane into the second flow circuit, and
circulating, before the blood treatment and by the blood treatment apparatus, said portion of the human-compatible fluid in the closed loop of the second flow circuit, to thereby sterilize said portion of the human-compatible fluid by the sterilizing filter.

18. A non-transitory, computer-readable medium storing instructions which, when executed by a processor, cause the processor to perform the method of claim 17 .

Assignees

• Gambro Lundia Ab

Inventors

• Nilsson Roger
• Ericson Björn
• Fors Jonas
• Forsland Karl Henrik

Classifications

• A61M2205/273

  preventing reuse, e.g. of disposables · CPC title

• A61M2205/7509

  for virus · CPC title

• A61M2205/50

  with microprocessors or computers · CPC title

• A61M2205/7518

  bacterial · CPC title

• A61M1/3646 Primary

  Expelling the residual body fluid after use, e.g. back to the body · CPC title