Micronized placental tissue compositions and methods of making and using the same

Patent metadata

Field	Value
Publication number	US-11931384-B2
Application number	US-202117644606-A
Country	US
Kind code	B2
Filing date	Dec 16, 2021
Priority date	Feb 14, 2011
Publication date	Mar 19, 2024
Grant date	Mar 19, 2024

Abstract

Described herein are compositions composed of micronized placental components and pharmaceutical compositions thereof. The compositions have numerous medical applications. Methods for making and using the micronized compositions are also described herein.

First claim

What is claimed:

1. A composition comprising dehydrated, micronized particles, wherein said particles are prepared by micronizing a dehydrated laminate comprising decontaminated amnion, decontaminated chorion, and decontaminated intermediate tissue layers; and
wherein the micronized particles have a particle size less than 400 μm.

2. The composition of claim 1 , wherein the weight ratio of amnion to intermediate tissue layer is from 10:1 to 1:10.

3. The composition of claim 1 , wherein the micronized particles have a particle size from 150 μm to 350 μm.

4. The composition of claim 1 , wherein the weight ratio of chorion to amnion is from 10:1 to 1:10.

5. The composition of claim 1 , wherein the weight ratio of chorion to amnion is from 4:1 to 1:1 and the micronized particles have a particle size from 25 μm to 200 μm.

6. The composition of claim 1 , wherein the composition further comprises a filler.

7. The composition of claim 6 , wherein the filler comprises allograft pericardium, allograft acellular dermis, Wharton's jelly, purified xenograft Type-1 collagen, biocellulose polymers or copolymers, biocompatible synthetic polymer or copolymer films, purified small intestinal submucosa, bladder acellular matrix, cadaveric fascia, or any combination thereof.

8. The composition of claim 6 , wherein the filler comprises Wharton's jelly.

9. The composition of claim 1 , wherein the amnion, chorion, intermediate tissue layer, or any combination thereof are cross-linked.

10. The composition of claim 1 , further comprising a bioactive agent.

11. The composition of claim 10 , wherein the bioactive agent comprises a hemostatic agent, a fibrin glue, an allograft, or an autogenous material.

12. The composition of claim 1 , wherein the composition further comprises a pharmaceutically acceptable carrier.

13. The composition of claim 12 , wherein the composition is injectable.

14. The composition of claim 12 , wherein the composition is a liquid, gel, or paste.

15. A three-dimensional construct comprising the composition of claim 1 , wherein the three-dimensional construct is produced by a process comprising (1) treating the micronized particles with a cross-linking agent and placing the treated particles in a mold or (2) admixing the micronized particles with an adhesive and placing the admixture in a mold.

16. A topical composition comprising the composition of claim 1 and a pharmaceutically acceptable carrier.

17. An implantable medical device comprising the composition of claim 1 .

Assignees

• Mimedx Group Inc

Inventors

• Morse Brenda S
• Sith Somaly
• Spencer Randall
• Ray Steven
• Daniel John
• Tofe Robert

Classifications

• A61L27/3604

  characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel · CPC title

• A61L2400/06

  Flowable or injectable implant compositions · CPC title

• A61L2430/34

  for soft tissue reconstruction · CPC title

• A61L27/3695

  characterised by the function or physical properties of the final product, where no specific conditions are defined to achieve this (A61L27/3687, A61L27/3691 take precedence) · CPC title

• A61P17/02

  for treating wounds, ulcers, burns, scars, keloids, or the like · CPC title