Modulation of neuronal nkcc1 as a therapeutic strategy for spasticity and related disorders
US-2024416127-A1 · Dec 19, 2024 · US
US11931327B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11931327-B2 |
| Application number | US-201816628232-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jul 3, 2018 |
| Priority date | Jul 4, 2017 |
| Publication date | Mar 19, 2024 |
| Grant date | Mar 19, 2024 |
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An object of the present invention is to provide a medicine that can simply treat and/or prevent a retinal degenerative disease associated with photoreceptor degeneration, including retinitis pigmentosa. The solution is to provide an agent for treating and/or preventing a retinal degenerative disease associated with photoreceptor degeneration, containing a compound having a retinoic acid receptor agonistic activity (for example, tamibarotene, tamibarotene methyl ester, tamibarotene ethyl ester, tazarotene, tazarotenic acid, adapalene, palovarotene, retinol, isotretinoin, alitretinoin, etretinate, acitretin or bexarotene) or a salt thereof.
Opening claim text (preview).
The invention claimed is: 1. A method for treating retinitis pigmentosa, comprising administering tamibarotene or tamibarotene ethyl ester, or a salt thereof. 2. The method according to claim 1 , wherein the method comprises administering tamibarotene. 3. The method according to claim 1 , wherein tamibarotene or tamibarotene ethyl ester, or the salt thereof, is topically administered to the eye.
having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid {(cannabinoids A61K31/658)} · CPC title
the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil · CPC title
Genetically modified vertebrates, e.g. transgenic · CPC title
Eye, e.g. artificial tears · CPC title
having an amino or nitro group · CPC title
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