Sample injection device and sample dissolution device

Patent metadata

Field	Value
Publication number	US-11921091-B2
Application number	US-202017636047-A
Country	US
Kind code	B2
Filing date	Feb 28, 2020
Priority date	Aug 21, 2019
Publication date	Mar 5, 2024
Grant date	Mar 5, 2024

Abstract

A sample injection device is used to inject a sample into a chromatograph and includes a flow vial, a sampling needle and one or more than one sample dissolution devices. A sample is supplied to the flow vial. The sample that has been supplied to the flow vial is collected by the sampling needle and injected into the chromatograph. At least one of ultrasonic waves, an electric field and a magnetic field is used, so that dissolution of a sample to be injected into the chromatograph is promoted by one or more than one sample dissolution devices.

First claim

The invention claimed is:

1. A sample injection device that injects a sample into a chromatograph, comprising:
a flow vial to which a sample solution is supplied;
a sampling needle configured to collect a sample of the sample solution supplied to the flow vial and inject the collected sample into the chromatograph;
a supply flow path configured to supply the sample solution to the flow vial;
a discharge flow path configured to discharge at least a portion of the sample solution supplied to the flow vial; and
one or more than one sample dissolution devices configured to promote dissolution of the sample solution using at least one of ultrasonic waves, an electric field and a magnetic field, wherein
the one or more than one sample dissolution devices include a first sample dissolution device attached to at least one of the supply flow path and the discharge flow path.

2. The sample injection device according to claim 1 , wherein
the one or more than one sample dissolution devices further include a second sample dissolution device attached to the flow vial.

3. The sample injection device according to claim 1 , wherein
the one or more than one sample dissolution devices further include a second sample dissolution device and a third sample dissolution device that are attached to at least two of the flow vial, the supply flow path and the discharge flow path.

4. The sample injection device according to claim 1 , wherein
the one or more than one sample dissolution devices are configured to promote dissolution of the sample solution by generating at least one of ultrasonic waves, an electric field and a magnetic field in a period including a point in time at which collection of the sample of the sample solution from the flow vial by the sampling needle ends.

5. The sample injection device according to claim 1 , further comprising a dilution vial configured to dilute the collected sample, wherein
prior to injecting the collected sample into the chromatograph, the sampling needle is configured to inject the sample collected from the flow vial into the dilution vial and then operate to inject the sample diluted by the dilution vial into the chromatograph, and
the one or more than one dissolution devices further include a second sample dissolution device attached to the dilution vial.

6. The sample injection device according to claim 1 , wherein
the one or more than one dissolution devices further include a second sample dissolution device attached to a storage that stores the sample solution to be supplied to the flow vial.

7. The sample injection device according to claim 1 , wherein
at least one of the one or more than one sample dissolution devices further includes a heater that heats the sample to promote dissolution of the sample solution.

Assignees

• Shimadzu Corp

Inventors

• Nagai Yusuke
• Iwata Yosuke

Classifications

• G01N30/20 Primary

  using a sampling valve · CPC title

• G01N30/24 Primary

  Automatic injection systems · CPC title

• G01N1/28

  Preparing specimens for investigation {including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q}(mounting specimens on microscopic slides G02B21/34; means for supporting the objects or the materials to be analysed in electron microscopes H01J37/20 {; laboratory gas handling apparatus B01L5/00}) · CPC title

• G01N1/00

  Sampling; Preparing specimens for investigation · CPC title

• G01N30/16

  Injection (G01N30/24 takes precedence) · CPC title