GPR183 antagonists for the treatment of pain

Patent metadata

Field	Value
Publication number	US-11919895-B2
Application number	US-202017080247-A
Country	US
Kind code	B2
Filing date	Oct 26, 2020
Priority date	Oct 25, 2019
Publication date	Mar 5, 2024
Grant date	Mar 5, 2024

Abstract

Disclosed herein are compositions and methods for treating neuropathic pain in a subject in need thereof. Compositions disclosed herein are GPR183 antagonists. The methods include administering to a subject in need thereof a therapeutically effective amount of a GPR183 antagonist.

First claim

What is claimed is:

1. A compound having a structure selected from the group consisting of:

2. A compound having a structure selected from the group consisting of:

Assignees

• Univ Saint Louis

Inventors

• Salvemini Daniela
• Arnatt Christopher K

Classifications

• C07D471/04 Primary

  Ortho-condensed systems · CPC title

• A61P23/00

  Anaesthetics · CPC title

• A61P25/02

  for peripheral neuropathies · CPC title

• C07D217/06

  with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates · CPC title

• C07D295/135

  with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings · CPC title