Reserve zirconium phosphate module for use in sorbent dialysis
US-2015367057-A1 · Dec 24, 2015 · US
US11918718B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11918718-B2 |
| Application number | US-202218056994-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 18, 2022 |
| Priority date | Apr 2, 2019 |
| Publication date | Mar 5, 2024 |
| Grant date | Mar 5, 2024 |
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The present disclosure features a composition, including molecularly imprinted crosslinked polymers that have been imprinted with trimethylamine N-oxide. The molecularly imprinted crosslinked polymers have specific binding sites for trimethylamine N-oxide, and a trimethylamine N-oxide absorption capacity of at least 0.5 mg/g.
Opening claim text (preview).
The embodiments of the invention in which an exclusive property or privilege is claimed are defined as follows: 1. A method of making a crosslinked polymer, comprising: polymerizing a monomer comprising a (C 0-6 alkyl)acrylic acid, di(C 1-6 alkyl)acrylic acid, or a combination thereof; and a crosslinker comprising a (C 1-6 alkylene glycol)-di(C 1-6 alkyl)acrylate, trimethylolpropane trimethacrylate, N,N′-methylenebisacrylamide, or any combination thereof; at a monomer:crosslinker ratio of from 1:9 to 14:1, in the presence of trimethylamine N-oxide and a solvent, to provide the crosslinked polymer, wherein the crosslinked polymer comprises specific binding sites for trimethylamine N-oxide and a trimethylamine N-oxide absorption capacity of at least 0.5 mg/g. 2. The method of claim 1 , further comprising grinding the crosslinked polymer to form the plurality of particles of the crosslinked polymers. 3. The method of claim 1 , wherein polymerizing the monomer and the crosslinker is in solution at a concentration of less than 180 mM to form a plurality of particles of the crosslinked polymers. 4. The method of claim 1 , wherein the solvent is selected from acetonitrile, methanol, water, dialysate solution, or any combination thereof. 5. The method of claim 1 , further comprising a radical initiator.
with dialysate regeneration · CPC title
using imprinted phases or molecular recognition · CPC title
Cross-linked polymers · CPC title
Polymers created by use of a template, e.g. molecularly imprinted polymers · CPC title
Sorbent size or size distribution, e.g. particle size · CPC title
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