Molecularly imprinted polymers for removal of trimethylamine N-oxide

US11918718B2 · US · B2

Patent metadata
FieldValue
Publication numberUS-11918718-B2
Application numberUS-202218056994-A
CountryUS
Kind codeB2
Filing dateNov 18, 2022
Priority dateApr 2, 2019
Publication dateMar 5, 2024
Grant dateMar 5, 2024

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  1. Title

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  2. Abstract

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  3. Assignees and inventors

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  4. Key dates

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  5. First independent claim

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Abstract

Official abstract text for this publication.

The present disclosure features a composition, including molecularly imprinted crosslinked polymers that have been imprinted with trimethylamine N-oxide. The molecularly imprinted crosslinked polymers have specific binding sites for trimethylamine N-oxide, and a trimethylamine N-oxide absorption capacity of at least 0.5 mg/g.

First claim

Opening claim text (preview).

The embodiments of the invention in which an exclusive property or privilege is claimed are defined as follows: 1. A method of making a crosslinked polymer, comprising: polymerizing a monomer comprising a (C 0-6 alkyl)acrylic acid, di(C 1-6 alkyl)acrylic acid, or a combination thereof; and a crosslinker comprising a (C 1-6 alkylene glycol)-di(C 1-6 alkyl)acrylate, trimethylolpropane trimethacrylate, N,N′-methylenebisacrylamide, or any combination thereof; at a monomer:crosslinker ratio of from 1:9 to 14:1, in the presence of trimethylamine N-oxide and a solvent, to provide the crosslinked polymer, wherein the crosslinked polymer comprises specific binding sites for trimethylamine N-oxide and a trimethylamine N-oxide absorption capacity of at least 0.5 mg/g. 2. The method of claim 1 , further comprising grinding the crosslinked polymer to form the plurality of particles of the crosslinked polymers. 3. The method of claim 1 , wherein polymerizing the monomer and the crosslinker is in solution at a concentration of less than 180 mM to form a plurality of particles of the crosslinked polymers. 4. The method of claim 1 , wherein the solvent is selected from acetonitrile, methanol, water, dialysate solution, or any combination thereof. 5. The method of claim 1 , further comprising a radical initiator.

Assignees

Inventors

Classifications

  • A61M1/1696Primary

    with dialysate regeneration · CPC title

  • using imprinted phases or molecular recognition · CPC title

  • Cross-linked polymers · CPC title

  • Polymers created by use of a template, e.g. molecularly imprinted polymers · CPC title

  • Sorbent size or size distribution, e.g. particle size · CPC title

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What does patent US11918718B2 cover?
The present disclosure features a composition, including molecularly imprinted crosslinked polymers that have been imprinted with trimethylamine N-oxide. The molecularly imprinted crosslinked polymers have specific binding sites for trimethylamine N-oxide, and a trimethylamine N-oxide absorption capacity of at least 0.5 mg/g.
Who is the assignee on this patent?
Univ Washington
What technology area does this patent fall under?
Primary CPC classification A61M1/1696. Mapped technology areas include Human Necessities.
When was this patent published?
Publication date Tue Mar 05 2024 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
What related patents are in patentsdb?
We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).