Device for producing nano particles and preparation method of nano particles using the same

Patent metadata

Field	Value
Publication number	US-11911519-B2
Application number	US-202117150037-A
Country	US
Kind code	B2
Filing date	Jan 15, 2021
Priority date	Jan 5, 2021
Publication date	Feb 27, 2024
Grant date	Feb 27, 2024

Abstract

A device for producing nanoparticles includes: a first connector comprising a first supply tube fitting member, a second supply tube fitting member, and a first discharge tube fitting member; a first tube having one side connected to the first supply tube fitting member; a second tube having one side connected to the second supply tube fitting member; a first conduit having one side connected to the first discharge tube fitting member; a first supply connected to another side of the first tube to supply a first material to the first conduit; and a second supply connected to another side of the second tube to supply a second material to the first conduit.

First claim

What is claimed is:

1. A device for producing nanoparticles, comprising:
a first connector comprising a first supply tube fitting member, a second supply tube fitting member, and a first discharge tube fitting member;
a first tube having one side connected to the first supply tube fitting member;
a second tube having one side connected to the second supply tube fitting member;
a first conduit having one side connected to the first discharge tube fitting member;
a first supply connected to another side of the first tube to supply a first material to the first conduit; and
a second supply connected to another side of the second tube to supply a second material to the first conduit,
wherein at least a portion of the first tube or the second tube is disposed in the first connector and in the first conduit,
wherein an outer diameter of the at least a portion of the first tube or the second tube disposed in the first conduit is smaller than an inner diameter of the first conduit,
wherein a length of the at least a portion of the first tube or the second tube disposed in the first conduit is shorter than a length of the first conduit,
wherein a material of the first connector, the first tube, and the second tube comprises a fluorine-based polymer,
wherein a material of the first conduit consists of a fluorine-based polymer, and
wherein the produced nanoparticles are reactive oxygen species (ROS)-reactive drug delivery nanoparticles.

2. The device for producing nanoparticles of claim 1 ,
wherein the first supply or the second supply is a diaphragm pump.

3. The device for producing nanoparticles of claim 1 , wherein the first connector further includes a third supply tube fitting member, and
the device for producing nanoparticles further comprises:
a third tube having one side connected to the third supply tube fitting member; and
a third supply connected to another side of the third tube to supply a third material to the first conduit.

4. The device for producing nanoparticles of claim 1 , further comprising:
a second connector comprising a connection tube fitting member, a fourth supply tube fitting member, and a second discharge tube fitting member;
the first conduit having one side connected to the connection tube fitting member;
a fourth tube having one side connected to the fourth supply tube fitting member;
a second conduit having one side connected to the second discharge tube fitting member; and
a fourth supply connected to another side of the fourth tube to supply a fourth material to the second conduit,
wherein a material of the second connector, the fourth tube, and the second conduit comprises a fluorine-based polymer.

5. The device for producing nanoparticles of claim 1 ,
wherein the first supply supplies the first material to the first conduit to form turbulence at an end portion of the at least a portion of the first tube in the first conduit, or
the second supply supplies the second material to the first conduit to form turbulence at an end portion of the at least a portion of the second tube in the first conduit.

6. The device for producing nanoparticles of claim 1 ,
wherein the first material and the second material are mixed while forming turbulence in the first conduit.

7. The device for producing nanoparticles of claim 6 ,
wherein a Reynolds number of a solution flow of a mixture of the first material and the second material is 800 or more.

8. The device for producing nanoparticles of claim 1 , wherein the nanoparticles formed by the device for producing nanoparticles are formed at a rate of 20 mg/min or more.

9. The device for producing nanoparticles of claim 1 ,
wherein the first material comprises a nano-precursor, and
the second material comprises a non-solvent.

10. The device for producing nanoparticles of claim 3 ,
wherein the third material comprises a nano-precursor, a non-solvent, a quenching material, or a surfactant.

Assignees

• Univ Soonchunhyang Ind Acad Coop Found
• Korea Inst Ceramic Eng & Tech

Inventors

• Lim Jong Min
• Sung Daekyung
• Choi Won Ii
• Han Hyeon Woo
• Jeong Sehee
• Na Yoonhee
• Woo Jiseob

Classifications

• A61K9/5192 Primary

  Processes · CPC title

• A61K9/5123

  Organic compounds, e.g. fats, sugars · CPC title

• B01F23/451

  by injecting one liquid into another · CPC title

• B01F23/49

  Mixing systems, i.e. flow charts or diagrams · CPC title

• B01F25/311

  for mixing more than two components; Devices specially adapted for generating foam · CPC title