Neuroactive steroids and methods of use thereof

US11905309B2 · US · B2

Patent metadata
FieldValue
Publication numberUS-11905309-B2
Application numberUS-202117381829-A
CountryUS
Kind codeB2
Filing dateJul 21, 2021
Priority dateMar 13, 2013
Publication dateFeb 20, 2024
Grant dateFeb 20, 2024

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  1. Title

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  2. Abstract

    A short plain-language summary of the technical disclosure.

  3. Assignees and inventors

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  4. Key dates

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  5. First independent claim

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  6. CPC / IPC classifications

    Technology tags used to group this patent with similar filings.

  7. Citations and related patents

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Abstract

Official abstract text for this publication.

3beta, 17beta disubstituted steroidal compounds, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, are provided for the prevention and treatment of a variety of CNS-related conditions.

First claim

Opening claim text (preview).

What is claimed is: 1. A compound or a pharmaceutically acceptable salt thereof selected from the group consisting of: and pharmaceutically acceptable salts thereof. 2. A pharmaceutical composition comprising a compound or pharmaceutically acceptable salt thereof according to claim 1 , and a pharmaceutically acceptable carrier. 3. The compound according to claim 1 , wherein the compound has the structure: and wherein the absolute stereochemistry is as shown. 4. The pharmaceutically acceptable salt of a compound according to claim 1 , wherein the compound has the structure: and wherein the absolute stereochemistry is as shown. 5. A pharmaceutical composition comprising the compound according to claim 3 and a pharmaceutically acceptable carrier. 6. A pharmaceutical composition comprising the pharmaceutically acceptable salt according to claim 4 and a pharmaceutically acceptable carrier. 7. The compound according to claim 1 wherein the compound has the structure: and wherein the absolute stereochemistry is as shown. 8. The pharmaceutically acceptable salt of a compound according to claim 1 , wherein the compound has the structure: and wherein the absolute stereochemistry is as shown. 9. A pharmaceutical composition comprising the compound according to claim 7 and a pharmaceutically acceptable carrier. 10. A pharmaceutical composition comprising the pharmaceutically acceptable salt according to claim 8 and a pharmaceutically acceptable carrier. 11. The compound according to claim 1 , wherein the compound has the structure: and wherein the absolute stereochemistry is as shown. 12. The pharmaceutically acceptable salt of a compound according to claim 1 , wherein the compound has the structure: and wherein the absolute stereochemistry is as shown. 13. A pharmaceutical composition comprising the compound according to claim 11 and a pharmaceutically acceptable carrier. 14. A pharmaceutical composition comprising the pharmaceutically acceptable salt according to claim 12 and a pharmaceutically acceptable carrier. 15. The compound according to claim 1 , wherein the compound has the structure: and wherein the absolute stereochemistry is as shown. 16. The pharmaceutically acceptable salt of a compound according to claim 1 , wherein the compound has the structure: and wherein the absolute stereochemistry is as shown. 17. A pharmaceutical composition comprising the compound according to claim 15 and a pharmaceutically acceptable carrier. 18. A pharmaceutical composition comprising the pharmaceutically acceptable salt according to claim 16 and a pharmaceutically acceptable carrier.

Assignees

Inventors

Classifications

  • substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol · CPC title

  • C07J9/005Primary

    containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton · CPC title

  • C07J9/00Primary

    Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane · CPC title

  • with double bond in position 16 (17) · CPC title

  • with double bond in position 17 (20) · CPC title

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Frequently asked questions

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What does patent US11905309B2 cover?
3beta, 17beta disubstituted steroidal compounds, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, are provided for the prevention and treatment of a variety of CNS-related conditions.
Who is the assignee on this patent?
Sage Therapeutics Inc
What technology area does this patent fall under?
Primary CPC classification C07J9/005. Mapped technology areas include Chemistry & Metallurgy.
When was this patent published?
Publication date Tue Feb 20 2024 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
What related patents are in patentsdb?
We list 12 related publications on this page (citations in our corpus or others sharing the same primary CPC).