Low power, chemically amplified, electrically removable barrier

Patent metadata

Field	Value
Publication number	US-11904045-B2
Application number	US-202117321296-A
Country	US
Kind code	B2
Filing date	May 14, 2021
Priority date	Jul 24, 2017
Publication date	Feb 20, 2024
Grant date	Feb 20, 2024

Abstract

An implantable device contains a drug or biosensing compound, protected from the external environment within a human body by several barriers which are broken upon activation of the device through electrothermal, chemical, and mechanical processes. The device allows accurate and repeated dosing within a human body, thus reducing the number of implantation procedures required. This device extends the lifetime of a biosensor, reducing the number of implantation procedures required.

First claim

What is claimed is:

1. A device, comprising:
a container having an opening;
a plurality of barriers closing the opening; and
a chemical compound or biological material within the container,
wherein:
the device is configured to be implantable within a human body or other organism,
the plurality of barriers is configured to electrochemically or electrothermally unseal, upon application of an electric potential or current to at least one barrier of the plurality of barriers, thereby allowing interaction between the chemical compound or biological material and the human body or other organism,
the plurality of barriers comprises:
a first barrier,
a second barrier having a greater mechanical stability than the first barrier and placed between the first barrier and the chemical compound or biological material, the second barrier being configured to electrochemically or mechanically unseal upon contact with the chemical compound, and
a third barrier placed between the second barrier and the chemical compound or biological material, the third barrier being not reactive to the chemical compound or biological material and being configured to electrochemically or electrothermally unseal when a current is applied to the third barrier, and

the first barrier is not reactive to the human body or other organism and is configured to mechanically break when the second barrier is electrochemically unsealed.

2. The device of claim 1 , wherein the chemical compound or biological material is selected from the group consisting of: a drug, and a biosensing material.

3. The device of claim 1 , wherein the first barrier is made of a material selected from the group consisting of: gold, platinum, silicon dioxide, silicon nitride and aluminum oxide.

4. The device of claim 1 , wherein the second barrier is made of magnesium.

5. The device of claim 1 , wherein the third barrier is made of gold.

6. The device of claim 1 , further comprising a reference electrode within the container, thereby being in contact with the chemical compound, wherein the reference electrode is electrically connected to the first barrier.

7. The device of claim 6 , wherein the reference electrode is made of a material selected from the group consisting of: Pt, and Ag/AgCl.

8. The device of claim 6 further comprising a counter electrode within the container, thereby being in contact with the chemical compound, wherein the counter electrode is electrically connected to the first barrier and reference electrode through a control circuit.

9. The device of claim 8 , wherein the counter electrode is made of Pt.

10. The device of claim 8 , further comprising a cathode electrode within the container, thereby being in contact with the chemical compound, wherein the cathode electrode is electrically connected to the second barrier.

11. The device of claim 10 , further comprising a galvanic cell controller or an energy harvesting unit, the galvanic cell controller or the energy harvesting unit being electrically connected to the cathode electrode and to the second barrier.

12. The device of claim 1 , wherein the applied electric current is less than one microAmpere and an area of a barrier of the plurality of barriers is smaller than 0.01 mm 2 .

13. The device of claim 1 , wherein the plurality of barriers further comprises an auxiliary compound configured to facilitate dissolution of the first barrier.

14. The device of claim 1 , wherein the plurality of barriers further comprises an auxiliary layer, wherein the auxiliary layer is configured to reduce an immune response to the device upon implantation in the human body or other organism.

15. A system comprising an array of devices, each device of the array of devices as described in claim 1 , wherein the system is configured to unseal the plurality of barriers of any one device of the array of devices, independently from adjacent devices of the array of devices.

Assignees

• California Inst Of Techn

Inventors

• Chen Samson
• Scherer Axel
• Smith Jr Richard Daniel

Classifications

• A61K9/0009 Primary

  involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis · CPC title

• A61B5/14532

  for measuring glucose, e.g. by tissue impedance measurement · CPC title

• A61B5/4839

  combined with drug delivery · CPC title

• A61B5/686

  Permanently implanted devices, e.g. pacemakers, other stimulators, biochips (A61B5/6861 takes precedence) · CPC title

• A61J1/1412

  Containers with closing means, e.g. caps · CPC title