Method for preparing an aqueous dispersion of metal oxide particles

Patent metadata

Field	Value
Publication number	US-11897785-B2
Application number	US-201917057626-A
Country	US
Kind code	B2
Filing date	May 22, 2019
Priority date	May 22, 2018
Publication date	Feb 13, 2024
Grant date	Feb 13, 2024

Abstract

A method for preparing an aqueous dispersion of metal oxide particles is disclosed. The method comprises the step of performing phase transfer of a plurality of metal oxide particles capped with hydrophobic ligands on a surface there of by contacting the metal oxide particles with a combination of tertiary amine and water to form a biphasic mixture, and agitating said biphasic mixture to produce an aqueous dispersion of metal oxide particles capped with hydrophobic ligands and tertiary amine ligands on the surface thereof.

First claim

The invention claimed is:

1. A method for preparing an aqueous dispersion of metal oxide particles, comprising the step of:
performing phase transfer of a plurality of metal oxide particles capped with hydrophobic ligands on a surface there of by contacting the metal oxide particles with a combination of tertiary amine and water to form a biphasic mixture, and agitating said biphasic mixture to produce an aqueous dispersion of metal oxide particles capped with hydrophobic ligands and tertiary amine ligands on the surface thereof.

2. A method according to claim 1 , wherein the biphasic mixture is agitated by sonicating the biphasic mixture for greater than 5 minutes.

3. A method according to claim 1 , wherein prior to the phase transfer step, the method further comprises the step of:
dissolving the tertiary amine in a solvent to form a solution of the tertiary amine;

wherein the solvent is a non-polar solvent selected from the group consisting of hexane, toluene and a combination thereof;
or wherein the solvent is a polar solvent selected from the group consisting of water, methanol, ethanol, propanol, an ether, chloroform, dimethyl formamide (DMF), dimethyl sulfoxide (DMSO), and any combination thereof.

4. A method according to claim 1 , further comprising the step of:
separating the metal oxide particles capped with hydrophobic ligands and tertiary amine ligands on the surface thereof from the aqueous dispersion using a physical separation procedure.

5. A method according to claim 1 , wherein the metal oxide particles capped with hydrophobic ligands and tertiary amine ligands are separated from the biphasic mixture by centrifuging the biphasic mixture at greater than 1000 g for greater than 2 minutes.

6. A method according to claim 1 , wherein the plurality of metal oxide particles are iron oxide particles, and prior to the phase transfer step of, the method further comprises the step of:
contacting an aqueous solution of iron (III) and iron (II) ions with a tertiary amine and hydrophobic ligands dissolved in an organic solvent to facilitate hydrolysis of the iron (III) and iron (II) ions to produce an organic dispersion of iron oxide particles capped with hydrophobic ligands on the surface thereof.

7. A method according to claim 6 , wherein the iron (III) and iron (II) ions are present in the aqueous solution in a 2:1 molar ratio.

8. A method according to claim 6 , wherein the organic solvent is miscible with the aqueous solution.

9. A method according to claim 8 , wherein the organic solvent is acetone.

10. A method according to claim 1 , wherein the tertiary amine is a trialkylamine.

11. A method according to claim 10 , wherein the trialkylamine is selected from the group consisting of triethylamine and trimethylamine.

12. A method according to claim 10 , wherein the tertiary amine is triethyiamine.

13. A method according to claim 1 , wherein the hydrophobic ligands are selected from the group consisting of an alkanoic acid, a saturated or unsaturated fatty acid, or a combination thereof.

14. A method according to claim 13 , wherein the hydrophobic ligands are oleic acid.

15. A method according to claim 1 , wherein the metal oxide particles are iron oxide particles.

16. A method according to claim 15 , wherein the iron oxide particles are maghemite (γ-Fe 2 O 3 ) and/or magnetite (Fe 3 O 4 ).

17. A method of using an aqueous dispersion of metal oxide particles produced according to the method of claim 1 as magnetic particles in a magnetism-mediated process selected from the group of processes consisting of magnetic hyperthermia treatment, magnetic labelling, magnetic separation, magnetic resonance imaging, magnetic particle imaging, magnetism-directed targeting and magnetism-induced heating.

18. A composition for use in a magnetism-mediated process comprising an aqueous dispersion of metal oxide particles produced according to the method of claim 1 , the magnetism-mediated process selected from the group of processes consisting of magnetic hyperthermia treatment, magnetic labelling, magnetic separation, magnetic resonance imaging, magnetic particle imaging, magnetism-directed targeting and magnetism-induced heating.

Assignees

• Melbourne Inst Tech

Inventors

• Bansal Vipul
• Singh Mandeep
• Ramanathan Rajesh
• Anderson Amanda

Classifications

• C01G49/0009 Primary

  Preparation involving a liquid-liquid extraction, an adsorption or an ion-exchange · CPC title

• A61K41/0052

  Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy · CPC title

• A61K49/1839

  the small organic molecule being a lipid, a fatty acid having 8 or more carbon atoms in the main chain, or a phospholipid · CPC title

• A61K49/1851

  having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule (peptide or protein A61K49/1866; polyamino acid A61K49/1872; antibody A61K49/1875) · CPC title

• C01G49/06

  Ferric oxide [Fe2O3] · CPC title