Composition for improving milk quality and preparation method and application thereof

Patent metadata

Field	Value
Publication number	US-11896580-B2
Application number	US-202117502735-A
Country	US
Kind code	B2
Filing date	Oct 15, 2021
Priority date	Oct 16, 2020
Publication date	Feb 13, 2024
Grant date	Feb 13, 2024

Abstract

The disclosure discloses a composition containing melatonin as an effective ingredient, and its application in improving DHI production performance and improving milk quality. The composition containing melatonin as an effective ingredient according to the present disclosure can significantly reduce the somatic cell count in milk and improve milk quality. Under the conditions of different seasons, ages, and lactation periods, the administration of the composition containing melatonin as an active ingredient according to the present disclosure can significantly reduce the somatic cell score of cow milk (p<0.01), increase the protein content and lactose content in milk, and meanwhile reduce the fat content and urea nitrogen content in milk. In summary, the composition containing melatonin as an effective ingredient according to the present disclosure can improve the quality of milk and increase the efficiency of dairy cow breeding.

First claim

What is claimed is:

1. A composition for improving milk quality of a dairy cow, comprising melatonin as an active ingredient, absolute ethanol and physiological saline; wherein the concentration of melatonin in the composition is of 1 to 20 mg/mL, and the volume ratio of absolute ethanol to physiological saline is in a range of (1-3):(1-2).

2. The composition according to claim 1 , wherein the volume ratio of absolute ethanol to physiological saline is 3:2.

3. A method for preparing the composition of claim 1 , comprising the following steps: dissolving melatonin in absolute ethanol and then adding physiological saline, wherein the steps are carried out in dark, the concentration of melatonin in the composition is of 1 to 20 mg/ml, and the volume ratio of absolute ethanol to physiological saline is in a range of (1-3):(1-2).

4. The method according to claim 3 , wherein the volume ratio of absolute ethanol to physiological saline is 3:2.

Assignees

• Univ China Agricultural

Inventors

• Liu Guoshi
• Wu Hao
• Lu Yongqiang
• Zhang Lu
• Ma Hui
• Chang Yi
• Liu Qiaoxiang
• Yao Songyang
• Ji Pengyun

Classifications

• A61K31/4045 Primary

  Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin · CPC title

• A61P15/14 Primary

  for lactation disorders, e.g. galactorrhoea · CPC title

• A61K9/0019

  Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner (non-active ingredients are additionally classified in A61K47/00) · CPC title

• A61K9/08

  Solutions {(composition of solutions A61K47/00)} · CPC title

• A61K47/02

  Inorganic compounds · CPC title