Implantable medical device using temperature sensor to determine infection status of patient

Patent metadata

Field	Value
Publication number	US-11896403-B2
Application number	US-202016751929-A
Country	US
Kind code	B2
Filing date	Jan 24, 2020
Priority date	Jan 24, 2020
Publication date	Feb 13, 2024
Grant date	Feb 13, 2024

Abstract

Techniques for detecting infections in a patient in relation to temperature values obtained from implantable temperature sensors are described. An example implantable temperature sensor may be included within a housing of an implantable medical device (IMD). In some examples, the temperature sensor may determine a plurality of temperature values over time. Processing circuitry of the IMD or of an external device may smooth the temperature values and apply an infection detection model to the smoothened temperature signal to determine an infection status of the patient.

First claim

What is claimed is:

1. A system for determining an infection status of a patient, the system comprising:
an implantable medical device (IMD) comprising at least one temperature sensing device and being configured to be implanted in a patient; and
processing circuitry configured to:
determine, via the temperature sensing device, a first plurality of temperature values over time;
smooth the first plurality of temperature values determined over time to create a first smoothened temperature signal representing changes in the first plurality of temperature values over a first time period;
smooth the first plurality of temperature values determined over time to create a second smoothened temperature signal representing changes in the first plurality of temperature values over the first time period, the second smoothened temperature signal being different than the first smoothened temperature signal;
apply an infection detection model to the first smoothened temperature signal and the second smoothened temperature signal to determine an infection indication value, wherein to apply the infection detection model, the processing circuitry is configured to, compare the first smoothened temperature signal to the second smoothened temperature signal, and increase the infection indication value each time when the second smoothened temperature signal comprises a value that is greater than a corresponding value of the first smoothened temperature signal;
compare the infection indication value to a threshold;
determine, based at least in part on the infection indication value satisfying the threshold, an infection status of the patient;
generate at least one of an alert or instructions for medical intervention for output that is based at least in part on the infection status of the patient; and
transmit the alert or instructions for medical intervention to an external device for use by the patient, a caregiver, or a clinician.

2. The system of claim 1 , wherein to smooth the first plurality of temperature values to create the first smoothened temperature signal, the processing circuitry is further configured to:
apply a first low pass filter to the first plurality of temperature values to create the first smoothened temperature signal over the first time period, the first low pass filter having a first cutoff frequency.

3. The system of claim 2 , wherein to smooth the first plurality of temperature values to create the second smoothened temperature signal, the processing circuitry is further configured to:
apply a second low pass filter to the plurality of temperature values over the first time period to create the second smoothened temperature signal, the second low pass filter having a second cutoff frequency higher than the first cutoff frequency.

4. The system of claim 1 , wherein the processing circuitry is further configured to:
reset the infection indication value to a baseline value each time when the second smoothened temperature signal comprises a value that is less than or equal to a corresponding value of the first smoothened temperature signal.

5. The system of claim 1 , wherein the infection status indicates an infection in a device pocket of the IMD.

6. The system of claim 1 , wherein the IMD comprises a second temperature sensor, wherein the processing circuitry is further configured to:
determine the first plurality of temperature values over time based at least in part on temperature measurements from at least the two temperature sensors included with the IMD.

7. The system of claim 1 , wherein the processing circuitry is further configured to change a therapy to be delivered to the patient based at least in part on the infection indication value satisfying the threshold.

8. The system of claim 7 , wherein the therapy comprises delivering a substance to the patient.

9. A method comprising:
determining, via a temperature sensing device of an implantable medical device (IMD) configured to be implanted in a patient, a first plurality of temperature values over time;
smoothing the first plurality of temperature values determined over time to create a first smoothened temperature signal representing changes in the first plurality of temperature values over a first time period;
smoothing the first plurality of temperature values determined over time to create a second smoothened temperature signal representing changes in the first plurality of temperature values over the first time period, the second smoothened temperature signal being different than the first smoothened temperature signal;
applying an infection detection model to the first smoothened temperature signal and the second smoothened temperature signal to determine an infection indication value, wherein applying the infection detection model comprises comparing the first smoothened temperature signal to the second smoothened temperature signal, and increase an infection indication value each time when the second smoothened temperature signal comprises a value that is greater than a corresponding value of the first smoothened temperature signal;
comparing the infection indication value to a threshold;
determining, based at least in part on the infection indication value satisfying the threshold, an infection status of the patient;
generating at least one of an alert or instructions for medical intervention for output that is based at least in part on the infection status of the patient; and
transmitting the alert or instructions for medical intervention to an external device for use by the patient, a caregiver, or a clinician.

10. The method of claim 9 , wherein smoothing the first plurality of temperature values to create the first smoothened temperature signal comprises:
applying a first low pass filter to the first plurality of temperature values to create the first smoothened temperature signal over the first time period, the first low pass filter having a first cutoff frequency.

11. The method of claim 10 , wherein smoothing the first plurality of temperature values to create the second smoothened temperature signal comprises:
applying a second low pass filter to the first plurality of temperature values over the first time period to create the second smoothened temperature signal, the second low pass filter having a second cutoff frequency higher than the first cutoff frequency.

12. The method of claim 9 , wherein the infection status indicates an infection in a device pocket of the IMD.

13. The method of claim 9 , wherein the IMD comprises a second temperature sensor, wherein the method further comprises:
determining the first plurality of temperature values over time based at least in part on temperature measurements from at least the two temperature sensors included with the IMD.

14. The method of claim 9 , further comprising:
resetting the infection indication value to a baseline value when the second smoothened temperature signal comprises a value that is less than or equal to a corresponding value of the first smoothened temperature signal.

15. The method of claim 9 , further comprising changing a therapy to be delivered to the patient based at least in part on the infection indication value satisfying the threshold.

16. The method of claim 15 , wherein the therapy comprises delivering a substance to the patient.

17. A non-transitory computer-readable storage medium having stored thereon instructions that, when executed, cause one or more processors to at least:
determine, via a temperature sensing device of an implantable medical device (IMD) configured to be implanted in a p

Assignees

• Medtronic Inc

Inventors

• Braganza Ameet
• Marshall Mark T
• Whitman Teresa A
• Stadler Robert W
• Lee Brian B

Classifications

• A61B5/7282 Primary

  Event detection, e.g. detecting unique waveforms indicative of a medical condition (cough events A61B5/0823; seizures A61B5/4094; sleep apnoea A61B5/4818) · CPC title

• A61B5/01

  Measuring temperature of body parts {; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue} (clinical contact thermometers G01K13/20) · CPC title

• A61B5/686

  Permanently implanted devices, e.g. pacemakers, other stimulators, biochips (A61B5/6861 takes precedence) · CPC title

• A61B5/7203

  for noise prevention, reduction or removal · CPC title

• A61B5/725

  using specific filters therefor, e.g. Kalman or adaptive filters (specific diagnostics methods using using bioelectric or biomagnetic signals A61B5/316) · CPC title