Microencapsulation of active agents

Patent metadata

Field	Value
Publication number	US-11896037-B2
Application number	US-201716323018-A
Country	US
Kind code	B2
Filing date	Aug 3, 2017
Priority date	Aug 3, 2016
Publication date	Feb 13, 2024
Grant date	Feb 13, 2024

Abstract

The present invention relates to compositions and methods for masking the taste of an agent. In certain aspects, the invention comprises a microsphere and at least one sweetener therein. In another aspect, the invention comprises an edible material comprising at least one microsphere comprising an agent and at least one microsphere comprising a sweetener.

First claim

The invention claimed is:

1. A microsphere comprising a sweetener and at least one material selected from the group consisting of a fatty acid, glycerol, esters, or a combination thereof, wherein the microsphere further comprises elaidic acid or glyceryl dibehenate.

2. The microsphere of claim 1 , wherein the microsphere further comprises stearic acid.

3. The microsphere of claim 2 , wherein the microsphere further comprises a lipid.

4. The microsphere of claim 3 , wherein the lipid is selected from the group consisting of linoleic acid, cocoa butter, and coconut oil.

5. The microsphere of claim 2 , wherein the sweetener is selected from the group consisting of an artificial sweetener, a sugar alcohol, and a natural sweetener.

6. The microsphere of claim 5 , wherein the sweetener is sucralose.

7. An edible material comprising at least one microsphere comprising at least one material selected from the group consisting of a fatty acid, glycerol, esters, or a combination thereof, wherein the microsphere further comprises elaidic acid or glyceryl dibehenate.

8. The edible material of claim 7 , comprising a therapeutic agent.

9. The edible material of claim 8 , wherein the therapeutic agent is selected from the group consisting of a protein, a peptide, a peptidomimetic, an antibody, a ribozyme, a small molecule chemical compound, a nucleic acid, a plasmid vector, and an antisense nucleic acid molecule.

10. The edible material of claim 7 , wherein the edible material comprises a microsphere comprising an agent and a microsphere comprising a sweetener.

11. The edible material of claim 7 , wherein the edible material is selected from the group consisting of an edible oral strip, a gummy candy, a hard candy, chocolate, sugar-free chocolate, ice cream, pudding, apple sauce, and yogurt.

12. The edible material of claim 7 , comprising an imaging agent.

13. The edible material of claim 7 , comprising a diagnostic agent.

14. The edible material of claim 7 , comprising a contrast agent.

15. The edible material of claim 7 , comprising a labeling agent.

Assignees

• Univ Temple

Inventors

• Smutzer Gregory S
• Lee Kevin
• Patel Dhruti

Classifications

• A23L27/72 Primary

  Encapsulation · CPC title

• A01N25/002

  containing a foodstuff as carrier or diluent, i.e. baits · CPC title

• A01N25/28

  Microcapsules {or nanocapsules} · CPC title

• A23G1/00

  Cocoa; Cocoa products, e.g. chocolate; Substitutes therefor (preservation thereof A23B80/00) · CPC title

• A23G1/54

  Composite products, e.g. layered, {laminated,} coated or filled · CPC title