Use of nootkatone to treat mosquito infestations

Patent metadata

Field	Value
Publication number	US-11896008-B2
Application number	US-202117494048-A
Country	US
Kind code	B2
Filing date	Oct 5, 2021
Priority date	Sep 2, 2016
Publication date	Feb 13, 2024
Grant date	Feb 13, 2024

Abstract

Compositions and methods for treating and preventing mosquito infestations are disclosed herein. Also disclosed herein are compositions and methods to reduce or prevent the spread of diseases for which mosquitoes may act as a vector.

First claim

What is claimed is:

1. A method of killing a mosquito larva, comprising:
applying an effective amount of a nootkatone-containing composition to a mosquito breeding site comprising one or more mosquito larvae,
wherein the one or more mosquito larvae are killed by the nootkatone applied to the mosquito breeding site.

2. The method of claim 1 , wherein the effective amount of the nootkatone-containing composition exposes the one or more mosquito larvae to a nootkatone concentration of about 0.01% to 0.03% (v/v) nootkatone at the mosquito breeding site.

3. The method of claim 1 , wherein the one or more mosquito larvae are members of the genera Anopheles, Aedes, Culex , or Haemagogus.

4. The method of claim 3 , wherein the one or more mosquito larvae are Aedes aegypti larvae.

5. The method of claim 1 , wherein the nootkatone is wholly or partially solubilised, liquefied, and/or dispersed in the nootkatone-containing composition.

6. The method of claim 5 , wherein the nootkatone-containing composition comprises ethanol, dichloromethane, ethyl acetate, hexane, an oil, a non-polar solvent, a surfactant, or a mixture or blend thereof.

7. The method of claim 5 , wherein the nootkatone-containing composition comprises a non-toxic, biodegradable nootkatone-solubilizing carrier or surfactant or a mixture or blend thereof.

8. The method of claim 1 , wherein the nootkatone-containing composition is applied to the mosquito breeding site about once per day, about once every 3 days, about once per week, about twice per week, about once per two weeks, about once per month, about once per two months, about once per three months, or about once per season.

9. The method of claim 8 , wherein the nootkatone-containing composition is applied using a dispenser.

10. The method of claim 9 , wherein the dispenser is a pouch, a puck, a pellet, a block, a granule, a vesicle, or a capsule.

11. The method of claim 9 , wherein the dispenser is refillable.

12. A method of killing a mosquito pupa, comprising:
applying an effective amount of a nootkatone-containing composition to a mosquito breeding site comprising one or more mosquito pupae, and
wherein the one or more mosquito pupae are killed by the nootkatone applied to the mosquito breeding site.

13. The method of claim 12 , wherein the effective amount of the nootkatone-containing composition exposes the one or more mosquito pupae to a nootkatone concentration of about 0.01% to 0.03% (v/v) nootkatone at the mosquito breeding site.

14. The method of claim 12 , wherein the one or more mosquito pupae are members of the genera Anopheles, Aedes, Culex , or Haemagogus.

15. The method of claim 14 , wherein the one or more mosquito pupae are Aedes aegypti pupae.

16. The method of claim 12 , wherein the nootkatone is wholly or partially solubilised, liquefied, and/or dispersed in the nootkatone-containing composition.

17. The method of claim 16 , wherein the nootkatone-containing composition comprises ethanol, dichloromethane, ethyl acetate, hexane, an oil, a non-polar solvent, a surfactant, or a mixture or blend thereof.

18. The method of claim 16 , wherein the nootkatone-containing composition comprises a non-toxic, biodegradable nootkatone-solubilizing carrier or surfactant or a mixture or blend thereof.

19. The method of claim 12 , wherein the nootkatone-containing composition is applied to the mosquito breeding site about once per day, about once every 3 days, about once per week, about twice per week, about once per two weeks, about once per month, about once per two months, about once per three months, or about once per season.

20. The method of claim 19 , wherein the nootkatone-containing composition is applied using a dispenser.

21. The method of claim 20 , wherein the dispenser is a pouch, a puck, a pellet, a block, a granule, a vesicle, or a capsule.

22. The method of claim 20 , wherein the dispenser is refillable.

23. A method of reducing the rate of mosquito egg hatching, comprising:
applying an effective amount of a nootkatone-containing composition to a mosquito breeding site comprising one or more unhatched mosquito eggs,
wherein the rate of mosquito egg hatching of the one or more unhatched mosquito eggs is reduced by the nootkatone applied to the mosquito breeding site.

24. The method of claim 23 , wherein the effective amount of the nootkatone-containing composition exposes the one or more unhatched mosquito eggs to a nootkatone concentration of about 0.01% to 0.03% (v/v) nootkatone at the mosquito breeding site.

25. The method of claim 23 , wherein the one or more unhatched mosquito eggs are members of the genera Anopheles, Aedes, Culex , or Haemagogus.

26. The method of claim 25 , wherein the one or more unhatched mosquito eggs are Aedes aegypti eggs.

27. The method of claim 23 , wherein the nootkatone is wholly or partially solubilised, liquefied, and/or dispersed in the nootkatone-containing composition.

28. The method of claim 27 , wherein the nootkatone-containing composition comprises ethanol, dichloromethane, ethyl acetate, hexane, an oil, a non-polar solvent, a surfactant, or a mixture or blend thereof.

29. The method of claim 27 , wherein the nootkatone-containing composition comprises a non-toxic, biodegradable nootkatone-solubilizing carrier or surfactant or a mixture or blend thereof.

30. The method of claim 23 , wherein the nootkatone-containing composition is applied to the mosquito breeding site about once per day, about once every 3 days, about once per week, about twice per week, about once per two weeks, about once per month, about once per two months, about once per three months, or about once per season.

31. The method of claim 30 , wherein the nootkatone-containing composition is applied using a dispenser.

32. The method of claim 31 , wherein the dispenser is a pouch, a puck, a pellet, a block, a granule, a vesicle, or a capsule.

33. The method of claim 31 , wherein the dispenser is refillable.

34. A method of reducing mosquito pupae eclosion, comprising:
applying an effective amount of a nootkatone-containing composition to a mosquito breeding site comprising one or more mosquito pupae,
wherein eclosion of the one or more mosquito pupae is reduced by the nootkatone applied to the mosquito breeding site.

35. The method of claim 34 , wherein the effective amount of the nootkatone-containing composition exposes the one or more mosquito pupae to a nootkatone concentration of about 0.01% to 0.03% (v/v) nootkatone at the mosquito breeding site.

36. The method of claim 34 , wherein the one or more mosquito pupae are members of the genera Anopheles, Aedes, Culex , or Haemagogus.

37. The method of claim 36 , wherein the one or more mosquito pupae are Aedes aegypti pupae.

38. The method of claim 34 , wherein the nootkatone is wholly or partially solubilised, liquefied, and/or dispersed in the nootkatone-containing composition.

39. The method of claim 38 , wherein the nootkatone-containing composition comprises ethanol, dichloromethane, ethyl acetate, hexane, an oil, a non-polar solvent, a surfactant, or a mixture or blend thereof.

40. The method

Assignees

• Evolva Sa

Inventors

• Amick Jean
• Murphy Ryan

Classifications

• A01N35/06 Primary

  containing keto or thioketo groups as part of a ring, e.g. cyclohexanone, quinone; Derivatives thereof, e.g. ketals · CPC title

• A01N25/04

  Dispersions, {emulsions, suspoemulsions, suspension concentrates} or gels (foams A01N25/16) · CPC title

• A01N25/30

  characterised by the surfactants · CPC title