Systems and methods for treating patients with diseases associated with viruses

Patent metadata

Field	Value
Publication number	US-11894148-B2
Application number	US-202117471962-A
Country	US
Kind code	B2
Filing date	Sep 10, 2021
Priority date	Dec 22, 2017
Publication date	Feb 6, 2024
Grant date	Feb 6, 2024

Abstract

Systems and methods are provided for treating an inflammatory or allergic response associated with a replicating pathogen, such as a virus in the coronaviridae family. The methods include emitting an electrical impulse near a vagus nerve within the patient sufficient to inhibit or reduce an inflammatory or allergic response in the patient, provide relief for bronchoconstriction that results in the tightening of airways and the inability to breath without ventilator support and/or lessen the abnormal blot clotting that develops in some patients. The systems and methods are particularly useful for treating post-COVID conditions or post-acute sequelae of COVID-19 that develop in “long-haul” or COVID patients.

First claim

The invention claimed is:

1. A method of treating a medical disorder associated with a virus in the coronaviridae family in a patient, the method comprising:
positioning a contact surface of a device in contact with an outer skin surface of a neck of the patient;
applying, via the device, when the contact surface is in contact with the outer skin surface of the neck of the patient, an electrical impulse transcutaneously, via the contact surface, through the outer skin surface of the neck of the patient to a vagus nerve of the patient; and
wherein the electrical impulse is sufficient to reduce a level of C-reactive protein in a blood of the patient by at least 10 mg/L, wherein the medical disorder is a virus in the coronaviridae family, wherein each of the pulses has a frequency of about 1 kHz to about 20 kHz and an amplitude of about 2 to 12 volts; and
wherein the electrical impulse is applied to the patient according to a treatment paradigm based at least in part on an application of the electrical impulse as a single dose of about 30 seconds to about 5 minutes from 2 to 5 times per day.

2. The method of claim 1 , wherein the electrical impulse is sufficient to reduce a level of procalcitonin in a blood of the patient.

3. The method of claim 2 , wherein the level of procalcitonin is reduced by at least 2 ng/L.

4. The method of claim 2 , wherein the level of procalcitonin is reduced by at least 5 ng/L.

5. The method of claim 1 , wherein the electrical impulse is sufficient to inhibit a release of a pro-inflammatory cytokine.

6. The method of claim 5 , wherein the cytokine includes a tumor necrosis factor(TNF)-alpha.

7. The method of claim 1 , wherein the device comprises one or more electrodes.

8. The method of claim 7 , wherein the device comprises a housing coupled to the one or more electrodes, the housing comprising an energy source that generates the electrical impulse.

9. The method of claim 1 , wherein the level of C-reactive protein is reduced by at least 25 mg/L.

10. The method of claim 1 , wherein the electrical impulse is sufficient to reduce the magnitude of constriction of smooth bronchial muscle.

11. The method of claim 1 , wherein the electrical impulse comprises bursts of 2-20 pulses with each of the bursts having a frequency of about 5 Hz to about 100 Hz.

Assignees

• Electrocore Inc

Inventors

• Errico Joseph P
• Simon Bruce J
• Staats Peter
• Errico Thomas

Classifications

• G16H50/80 Primary

  for detecting, monitoring or modelling epidemics or pandemics, e.g. flu · CPC title

• A61N1/36

  for stimulation · CPC title

• A61N1/36034

  specified by the stimulation parameters · CPC title

• A61N1/36053

  adapted for vagal stimulation (A61N1/36114 takes precedence) · CPC title

• G16B35/00

  ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides · CPC title