Infusion preparation
US-9884149-B2 · Feb 6, 2018 · US
Transfusion preparation
US11890372B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11890372-B2 |
| Application number | US-201916980201-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 13, 2019 |
| Priority date | Mar 13, 2018 |
| Publication date | Feb 6, 2024 |
| Grant date | Feb 6, 2024 |
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- Title
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- Abstract
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Abstract
Official abstract text for this publication.
The present invention provides an infusion preparation that is inhibited from generation of unwanted insoluble matter after mixing of two liquids of the infusion preparation in long-term storage. More specifically, the present invention provides an infusion preparation comprising two chambers separated by a communicably openable partition, a first chamber containing a first-chamber infusion comprising a fat emulsion and further comprising at least one member selected from the group consisting of amino acids that have a buffer action, divalent organic acids, and trivalent organic acids, a second chamber containing a second-chamber infusion comprising an amino acid and at least calcium as an electrolyte, wherein a total concentration of the amino acids that have a buffer action, divalent organic acids, and trivalent organic acids in the first-chamber infusion is 0.15 to 0.5 g/L, and a mixture of the first- and second-chamber infusions has a pH of 6.53 or less as measured 48 hours after the partition is communicably opened.
First claim
Opening claim text (preview).
The invention claimed is: 1. An infusion preparation comprising two chambers separated by a communicably openable partition, a first chamber containing a first-chamber infusion comprising a fat emulsion and further comprising at least one member selected from the group consisting of amino acids that have a buffer action, divalent organic acids, and trivalent organic acids, a second chamber containing a second-chamber infusion comprising an amino acid and at least calcium as an electrolyte, wherein a total concentration of the amino acids that have a buffer action, divalent organic acids, and trivalent organic acids in the first-chamber infusion is 0.15 to 0.5 g/L, and a mixture of the first- and second-chamber infusions has a pH of 6.53 or less as measured 48 hours after the partition is communicably opened. 2. The infusion preparation according to claim 1 , wherein the fat emulsion comprises an emulsifying agent, and the first-chamber infusion comprises the emulsifying agent in a concentration of 0.01 to 2 w/v %. 3. The infusion preparation according to claim 1 , wherein the mixture of the first- and second-chamber infusions after the partition is communicably opened contains Ca 2+ in a concentration of 1 mEq/L or more. 4. The infusion preparation according to claim 1 , wherein the second-chamber infusion further comprises at least citric acid as the electrolyte, and the second-chamber infusion has a citric acid concentration (mEq) equal to or more than the calcium concentration (mEq). 5. The infusion preparation according to claim 1 , wherein the first-chamber infusion comprises at least histidine as the amino acids that have a buffer action. 6. A mixture of the first- and second-chamber infusions of claim 1 obtained by communicably opening the partition.
Assignees
Inventors
Classifications
- A61K9/0029Primary
Parenteral nutrition; Parenteral nutrition compositions as drug carriers · CPC title
Fatty acids or derivatives thereof; Fats or oils · CPC title
Inorganic salts, minerals or trace elements · CPC title
Amino acids · CPC title
Containers having several compartments for products to be mixed · CPC title
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Frequently asked questions
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- What does patent US11890372B2 cover?
- The present invention provides an infusion preparation that is inhibited from generation of unwanted insoluble matter after mixing of two liquids of the infusion preparation in long-term storage. More specifically, the present invention provides an infusion preparation comprising two chambers separated by a communicably openable partition, a first chamber containing a first-chamber infusion com…
- Who is the assignee on this patent?
- Otsuka Pharma Factory Inc
- What technology area does this patent fall under?
- Primary CPC classification A61K9/0029. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Feb 06 2024 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 5 related publications on this page (citations in our corpus or others sharing the same primary CPC).