Enolase 1 (eno1) compositions and uses thereof
US-2015359861-A1 · Dec 17, 2015 · US
PH-responsive polymer and drug delivery system
US11890347B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11890347-B2 |
| Application number | US-201716468199-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 5, 2017 |
| Priority date | Dec 15, 2016 |
| Publication date | Feb 6, 2024 |
| Grant date | Feb 6, 2024 |
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Abstract
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A pH-responsive polymer formed of a biocompatible polymer to which a group which is electrically neutral under pH environments of more than 7 and which changes to be cationic at pH 7 or less is bonded.
First claim
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The invention claimed is: 1. A pH-responsive polymer, comprising: a biocompatible polymer in which a side chain thereof including a group represented by Formula (1), a group represented by Formula (2), or a group represented by Formula (3) is bonded via a linking group containing an amide bond, wherein the biocompatible polymer is polyglutamic acid or polyaspartic acid, wherein the linking group containing an amide bond is bonded to the main chain of the biocompatible polymer, and the side chain is electrically neutral under pH environments of 7.2 to 7.6 and which changes to be cationic under pH environments of 6.0 to 6.6: in Formulas (1) to (3), n represents an integer of 1 to 3, and * represents a bond. 2. The pH-responsive polymer according to claim 1 , wherein the biocompatible polymer is biodegradable. 3. The pH-responsive polymer according to claim 1 , comprising: a repeating unit represented by Formula (b). 4. The pH-responsive polymer according to claim 1 , comprising: a repeating unit represented by Formula (c) (in Formula (c), n represents 2 or 3). 5. The pH-responsive polymer according to claim 1 , wherein a weight-average molecular weight is 1,000 to 200,000. 6. The pH-responsive polymer according to claim 5 , wherein a weight-average molecular weight is 10,000 to 50,000. 7. The pH-responsive polymer according to claim 1 , wherein 4 to 800 moles of the side chain which is electrically neutral under pH environments of 7.2 to 7.6 and which changes to be cationic under pH environments of 6.0 to 6.6 is bonded per one mole of the biocompatible polymer. 8. The pH-responsive polymer according to claim 1 , which is for a drug delivery system. 9. A drug delivery system comprising, the pH-responsive polymer according to claim 1 ; and a drug bonded to the pH-responsive polymer.
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- What does patent US11890347B2 cover?
- A pH-responsive polymer formed of a biocompatible polymer to which a group which is electrically neutral under pH environments of more than 7 and which changes to be cationic at pH 7 or less is bonded.
- Who is the assignee on this patent?
- Tokyo Inst Tech
- What technology area does this patent fall under?
- Primary CPC classification A61K47/59. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Feb 06 2024 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).