Nerve regeneration-inducing material
US-2019083678-A1 · Mar 21, 2019 · US
Adhesion-preventing composition
US11890145B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11890145-B2 |
| Application number | US-202217896474-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 26, 2022 |
| Priority date | Jul 13, 2016 |
| Publication date | Feb 6, 2024 |
| Grant date | Feb 6, 2024 |
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- Title
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Abstract
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An adhesion-preventing material having a high adhesion-preventing effect has been demanded. An adhesion-preventing material including a sterilized biocompatible sponge-like laminate, wherein the sponge-like laminate comprises a sponge-like first layer and a sponge-like second layer each of which is at least partially crosslinked with a curing agent and comprises a low-endotoxin alginic acid monovalent metal salt, the alginic acid monovalent metal salt in the first layer has a weight average molecular weight of 10,000 to 2,000,000, the alginic acid monovalent metal salt in the second layer has a weight average molecular weight of 1,000 to 1,000,000, the weight average molecular weights are measured by a GPC-MALS method after a decrosslinking treatment, and the weight average molecular weight of the alginic acid monovalent metal salt in the first layer is higher than that in the second layer.
First claim
Opening claim text (preview).
The invention claimed is: 1. A method for preventing an adhesion, comprising applying a sterilized biocompatible sponge-like laminate that includes first and second sponge-like layers containing low-endotoxin monovalent metal salts of alginic acid which are at least partially crosslinked with a curing agent, wherein a weight average molecular weight of the monovalent metal salt of alginic acid in the first layer is 10,000-2,000,000, a weight average molecular weight of the monovalent metal salt of alginic acid in the second layer is 1,000-1,000,000, the weight average molecular weights are measured by GPC-MALS method following a decrosslinking treatment, and the weight average molecular weight of the monovalent metal salt of alginic acid in the first layer is higher than the weight average molecular weight of the monovalent metal salt of alginic acid in the second layer, to a subject in need of adhesion prevention. 2. The method according to claim 1 , wherein either one of the first layer and the second layer comprises a curing agent. 3. The method according to claim 1 , wherein each of the first layer and the second layer comprises a curing agent. 4. The method according to claim 1 , wherein the total amount of the low-endotoxin monovalent metal salts of alginic acid used in the first layer and the second layer is in a range of 0.1 mg/cm 2 -3 mg/cm 2 . 5. The method according to claim 1 , wherein the endotoxin content of the monovalent metal salts of alginic acid in the first layer and the second layer is 500 EU/g or less. 6. The method according to claim 1 , wherein the monovalent metal salt of alginic acid in each of the first layer and the second layer are is selected from the group consisting of sodium alginate and potassium alginate. 7. The method according to claim 1 , wherein the curing agent in each of the first layer and the second layer is at least one metal ionic compound selected from the group consisting of CaCl 2 , CaSO 4 , ZnCl 2 , SrCl 2 , FeCl 3 and BaCl 2 . 8. The method according to claim 1 , wherein the sponge-like laminate is pressed. 9. The method according to claim 1 , wherein the sponge-like laminate is mixed or impregnated with a drug.
Assignees
Inventors
Classifications
- A61B90/08Primary
Accessories or related features not otherwise provided for · CPC title
Macromolecular materials · CPC title
Composite materials, i.e. containing one material dispersed in a matrix of the same or different material · CPC title
containing other specific inorganic fillers not covered by A61L31/126 or A61L31/127 · CPC title
Materials characterised by their function or physical properties {, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials} · CPC title
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- What does patent US11890145B2 cover?
- An adhesion-preventing material having a high adhesion-preventing effect has been demanded. An adhesion-preventing material including a sterilized biocompatible sponge-like laminate, wherein the sponge-like laminate comprises a sponge-like first layer and a sponge-like second layer each of which is at least partially crosslinked with a curing agent and comprises a low-endotoxin alginic acid mon…
- Who is the assignee on this patent?
- Mochida Pharm Co Ltd, Univ Tokyo
- What technology area does this patent fall under?
- Primary CPC classification A61B90/08. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Feb 06 2024 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 4 related publications on this page (citations in our corpus or others sharing the same primary CPC).