Stimulus activated cork-shell capsules

Patent metadata

Field	Value
Publication number	US-11883540-B2
Application number	US-202117320446-A
Country	US
Kind code	B2
Filing date	May 14, 2021
Priority date	May 15, 2020
Publication date	Jan 30, 2024
Grant date	Jan 30, 2024

Abstract

The present application relates to a vehicle whose shell material is modified with at least one additional secondary phase that acts as a cork. In the presence of an energy source (preferably ultrasound), the corks embedded in the shell are either removed from the shell to create permanent pores or perturbed within the shell to create transient pores that can control transport in or out of the vehicle.

First claim

The invention claimed is:

1. A core-shell particle, comprising
1) An outer shell comprising at least one first polymer; and
2) at least one particulate phase embedded and/or dispersed within the outer shell, wherein the particulate phase comprises at least one inorganic oxide, metal salt, polymer, organometallic compound or contrast agent, and wherein the at least one particulate phase is releasable from or perdurable within the outer shell to create a pore in the outer shell upon exposure to an external stimulus, and wherein the at least one particulate phase has a different mechanical index from the outer shell.

2. The core-shell particle of claim 1 , wherein the at least one particulate phase is irreversibly released from the outer shell.

3. The core-shell particle of claim 1 , wherein the at least one particulate phase is transiently perturbed within the outer shell.

4. The core-shell particle of claim 1 , wherein the polymer of the shell is a polyester, a polyurethane, a poly(meth)acrylate, a poly(amino ester), a polyanhydride, a polyimide, a polyurea, a polyolefin, or copolymers thereof.

5. The core-shell particle of claim 4 , wherein the polymer of the shell is a polyester.

6. The core-shell particle of claim 5 , wherein the polyester is poly(lactic acid-co-glycolic acid).

7. The core-shell particle of claim 6 , wherein the poly(lactic acid-co-glycolic acid) has the formula

wherein m and n are integers from 1 to 10,000.

8. The core-shell particle of claim 1 , wherein the at least one particulate phase comprises an inorganic oxide.

9. The core-shell particle of claim 8 , wherein the inorganic oxide is silicon dioxide, sodium oxide, calcium oxide, potassium oxide, barium oxide, or mesoporous silica, or mixtures thereof.

10. The core-shell particle of claim 9 , wherein the inorganic oxide is silicon dioxide.

11. The core-shell particle of claim 1 , wherein the at least one particulate phase comprises an inorganic oxide covalently linked to a second polymer.

12. The core-shell particle of claim 11 , wherein the silicon dioxide is covalently linked to the second polymer with an amine linker.

13. The core-shell particle of claim 12 , wherein the second polymer is a polyester, a polyurethane, a poly(meth)acrylate, a poly(amino ester), a polyurea, a polyolefin, or copolymers thereof.

14. The core-shell particle of claim 13 , wherein the polyester is poly(lactic acid-co-glycolic acid).

15. The core-shell particle of claim 14 , wherein the poly(lactic acid-co-glycolic acid) has the formula

wherein m and n are integers from 1 to 10,000.

16. The core-shell particle of claim 1 , wherein the at least one particulate phase has the following formula

wherein m and n are integers from 1 to 10,000.

17. The core-shell particle of claim 1 , wherein the outer shell defines an inner core comprising one or more materials which are released from the inner core upon exposure to the stimulus.

18. The core-shell particle of claim 17 , wherein the one or more materials comprise a biologically active entity, an inorganic material, or combinations thereof.

19. The core-shell particle of claim 18 , wherein the biologically active entity is a drug, a protein, an antibody, an enzyme, a polynucleotide, or a particulate, complex, or conjugate formulation thereof.

20. The core-shell particle of claim 18 , wherein the inorganic material is a salt, a metal, a ceramic, an imaging agent, or a particulate, complex, or conjugate formulation thereof.

21. The core-shell particle of claim 1 , wherein the stimulus is ultrasound, a magnetic field, irradiation, a pH change, a temperature change, or enzymatic activity.

22. The core-shell particle of claim 17 , wherein the release or perturbation of the at least one particulate phase within the outer shell upon exposure to an external stimulus mediates the transport of one or more entities into the inner core.

23. The core-shell particle of claim 22 in which one or more entities transporting into the inner core are analytes for an encapsulated sensor.

Assignees

• Univ Mcmaster

Inventors

• Hoare Todd
• Dorogin Jonathan
• Koff David
• Singh Andrew

Classifications

• A61K9/5031 Primary

  obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide) · CPC title

• A61K9/0009

  involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis · CPC title

• A61K9/501

  Inorganic compounds · CPC title

• A61K9/08 Primary

  Solutions {(composition of solutions A61K47/00)} · CPC title

• A61K9/1641

  obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers · CPC title